FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3141569679> ?p ?o ?g. }

• W3141569679 endingPage "1567" @default.
• W3141569679 startingPage "1567" @default.
• W3141569679 abstract "Childhood cancer survivors are highly exposed to the development of side effects after many years of cessation of anticancer treatment, including altered lipid metabolism that may result in an increased risk of overweight and metabolic syndrome. Adipocyte (A-FABP) and epidermal (E-FABP) fatty acid-binding proteins are expressed in adipocytes and are assumed to play an important role in the development of lipid disturbances leading to the onset of metabolic syndrome. The aim of this study was to investigate the association between serum A-FABP and E-FABP levels, overweight, and components of the metabolic syndrome in acute lymphoblastic leukemia survivors. Sixty-two acute lymphoblastic leukemia (ALL) survivors (34 females) were included in the study. The mean age at the time of the study was 12.41 ± 4.98 years (range 4.71–23.43). Serum levels of A-FABP and E-FABP were analyzed using a commercially available ELISA kit. The ALL survivors presented statistically higher A-FABP levels in comparison with the healthy controls (25.57 ± 14.46 vs. 15.13 ± 7.61 ng/mL, p < 0.001). The subjects with body mass index (BMI) above the normal range (18 overweight, 10 obese) had a greater level of A-FABP compared to the ALL group with normal BMI (32.02 ± 17.10 vs. 20.33 ± 9.24 ng/mL, p = 0.006). Of all participants, 53.23% had at least one risk factor of metabolic syndrome; in this group, only the A-FABP level showed a statistically significant difference compared to the healthy control group (30.63 ± 15.91 vs. 15.13 ± 7.61 ng/mL, p < 0.001). The subjects with two or more metabolic risk factors (16.13%) presented higher levels of both A-FABP (33.62 ± 17.16 vs. 15.13 ± 7.61 ng/mL, p = 0.001) and E-FABP (13.37 ± 3.62 vs. 10.12 ± 3.21 ng/mL, p = 0.021) compared to the controls. Univariable regression models showed significant associations between BMI and systolic blood pressure with the A-FABP level (coeff. 1.02 and 13.74, respectively; p < 0.05). In contrast, the E-FABP level was only affected by BMI (coeff. 0.48; p < 0.01). The findings reported herein suggest that the increased levels of A-FABP and E-FABP may be involved in the pathogenesis of overweight and the onset of metabolic syndrome in acute lymphoblastic leukemia. However, further longitudinal, prospective studies of fatty acid-binding proteins and their potential role in the pathogenesis of obesity and metabolic syndrome in ALL survivors remain to be performed." @default.
• W3141569679 created "2021-04-13" @default.
• W3141569679 creator A5010607883 @default.
• W3141569679 creator A5032725451 @default.
• W3141569679 creator A5054207725 @default.
• W3141569679 creator A5061924630 @default.
• W3141569679 creator A5070341654 @default.
• W3141569679 date "2021-04-08" @default.
• W3141569679 modified "2023-10-16" @default.
• W3141569679 title "Increased Levels of Adipocyte and Epidermal Fatty Acid-Binding Proteins in Acute Lymphoblastic Leukemia Survivors" @default.
• W3141569679 cites W1558704041 @default.
• W3141569679 cites W1631760388 @default.
• W3141569679 cites W1932207823 @default.
• W3141569679 cites W1974549941 @default.
• W3141569679 cites W1983691371 @default.
• W3141569679 cites W1987350713 @default.
• W3141569679 cites W2008283534 @default.
• W3141569679 cites W2015758016 @default.
• W3141569679 cites W2025321364 @default.
• W3141569679 cites W2040819104 @default.
• W3141569679 cites W2046722666 @default.
• W3141569679 cites W2052051096 @default.
• W3141569679 cites W2064343507 @default.
• W3141569679 cites W2071490381 @default.
• W3141569679 cites W2073850554 @default.
• W3141569679 cites W2081705352 @default.
• W3141569679 cites W2082324230 @default.
• W3141569679 cites W2090911565 @default.
• W3141569679 cites W2092284812 @default.
• W3141569679 cites W2095876186 @default.
• W3141569679 cites W2103633907 @default.
• W3141569679 cites W2111498373 @default.
• W3141569679 cites W2111574921 @default.
• W3141569679 cites W2113525441 @default.
• W3141569679 cites W2124409007 @default.
• W3141569679 cites W2125089267 @default.
• W3141569679 cites W2133374684 @default.
• W3141569679 cites W2166241909 @default.
• W3141569679 cites W2168581409 @default.
• W3141569679 cites W2344494814 @default.
• W3141569679 cites W2417421816 @default.
• W3141569679 cites W2514013076 @default.
• W3141569679 cites W2554898019 @default.
• W3141569679 cites W2593685779 @default.
• W3141569679 cites W2606419213 @default.
• W3141569679 cites W2734208132 @default.
• W3141569679 cites W2771787626 @default.
• W3141569679 cites W2773095864 @default.
• W3141569679 cites W2780399894 @default.
• W3141569679 cites W2795310028 @default.
• W3141569679 cites W2807530416 @default.
• W3141569679 cites W2886026800 @default.
• W3141569679 cites W3005639301 @default.
• W3141569679 doi "https://doi.org/10.3390/jcm10081567" @default.
• W3141569679 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8068128" @default.
• W3141569679 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33917805" @default.
• W3141569679 hasPublicationYear "2021" @default.
• W3141569679 type Work @default.
• W3141569679 sameAs 3141569679 @default.
• W3141569679 citedByCount "4" @default.
• W3141569679 countsByYear W31415696792022 @default.
• W3141569679 countsByYear W31415696792023 @default.
• W3141569679 crossrefType "journal-article" @default.
• W3141569679 hasAuthorship W3141569679A5010607883 @default.
• W3141569679 hasAuthorship W3141569679A5032725451 @default.
• W3141569679 hasAuthorship W3141569679A5054207725 @default.
• W3141569679 hasAuthorship W3141569679A5061924630 @default.
• W3141569679 hasAuthorship W3141569679A5070341654 @default.
• W3141569679 hasBestOaLocation W31415696791 @default.
• W3141569679 hasConcept C104317684 @default.
• W3141569679 hasConcept C126322002 @default.
• W3141569679 hasConcept C134018914 @default.
• W3141569679 hasConcept C171089720 @default.
• W3141569679 hasConcept C2776175234 @default.
• W3141569679 hasConcept C2776834966 @default.
• W3141569679 hasConcept C2778461978 @default.
• W3141569679 hasConcept C2780221984 @default.
• W3141569679 hasConcept C2780578515 @default.
• W3141569679 hasConcept C2780586474 @default.
• W3141569679 hasConcept C2909962599 @default.
• W3141569679 hasConcept C42407357 @default.
• W3141569679 hasConcept C511355011 @default.
• W3141569679 hasConcept C55493867 @default.
• W3141569679 hasConcept C71924100 @default.
• W3141569679 hasConcept C86803240 @default.
• W3141569679 hasConceptScore W3141569679C104317684 @default.
• W3141569679 hasConceptScore W3141569679C126322002 @default.
• W3141569679 hasConceptScore W3141569679C134018914 @default.
• W3141569679 hasConceptScore W3141569679C171089720 @default.
• W3141569679 hasConceptScore W3141569679C2776175234 @default.
• W3141569679 hasConceptScore W3141569679C2776834966 @default.
• W3141569679 hasConceptScore W3141569679C2778461978 @default.
• W3141569679 hasConceptScore W3141569679C2780221984 @default.
• W3141569679 hasConceptScore W3141569679C2780578515 @default.
• W3141569679 hasConceptScore W3141569679C2780586474 @default.
• W3141569679 hasConceptScore W3141569679C2909962599 @default.
• W3141569679 hasConceptScore W3141569679C42407357 @default.
• W3141569679 hasConceptScore W3141569679C511355011 @default.

• next