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• W3144089239 abstract "85 kDa (CIN85 ) 的最新发现的交往 Cbl 蛋白质在大脑涉及许多细胞的过程，而是它的功能，在 neurodegenerative，疾病仍然保持不清楚。在这篇论文，我们用蛋白质印迹分析和免疫组织化学在成年老鼠大脑的不同区域调查了 CIN85 蛋白质的分发，并且发现 CIN85 无所不在地在老鼠大脑被表示。在条纹弦音器和 substantia nigra，二个区域最深深地在 Parkinson 的疾病影响了， CIN85 蛋白质的水平相对高。在 Parkinson 的疾病的 MPTP 鼠标模型，在条纹弦音器和 substantia nigra 的 CIN85 的表达式是复杂的。但是在 1-methyl-4-phenyl-pyridinium 对待离子的人的 dopaminergic SH-SY5Y 房间， CIN85 的表示戏剧性地增加了。由短发卡 RNA CIN85 击倒减少了 SH-SY5Y 房间死亡。因此， CIN85 可能在神经毒素挑战下面在 dopaminergic 房间线并且在老鼠大脑的 nigrostriatum 起不同作用。" @default.
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• W3144089239 date "2008-01-01" @default.
• W3144089239 modified "2023-10-18" @default.
• W3144089239 title "Expression of Cbl-interacting protein of 85 kDa in MPTP mouse model of Parkinson＇s disease and 1-methyl-4-phenyl-pyridinium ion-treated dopaminergic SH-SY5Y cells" @default.
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