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• W3146028411 abstract "AIM: To elucidate the role of fibulin-5(FBLN-5) as a suppressor of hepatocellular carcinoma(HCC) cell metastasis via integrin.METHODS: The expression of FBLN-5 was determined by immunohistochemistry in 140 HCC samples and matched normal tissues, and was further confirmed by RT-PCR and Western blot analyses in various cell lines. Recombinant FBLN-5 was expressed in Escherichia coli BL21(DE3), purified and used in cell attachment assays. Expression of a specific plasmid or a specific si RNA in HCC cells resulted in the overexpression or knockdown of FBLN-5, respectively. Further, the migration and invasion of HCC cells were investigated using the Boyden chamber and transwell assays. The concentration of secreted matrix metalloproteinase 7(MMP-7) was determined using ELISA. RESULTS: FBLN-5 expression was found to be downregulated in HCC. Its expression was significantly correlated with advanced tumor metastasis; this was indicative of poor 5-year overall survival. Recombinant full-length human FBLN-5 promoted the attachment of HCC cells via integrins: it inhibited HCC cell adhesionand migration to fibronectin in a concentrationdependent manner. It also inhibited HCC cell migration and invasion through an integrin-binding arginineglycine-aspartic acid(RGD) motif by downregulating MMP-7. CONCLUSION: These results suggest that lower FBLN-5 expression is an important indicator of poor survival and that FBLN-5 inhibits HCC motility via an integrin-dependent mechanism. RGD-dependent suppression of MMP-7 by FBLN-5 might contribute to the development of new therapeutic strategies for HCC." @default.
• W3146028411 created "2021-04-13" @default.
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• W3146028411 date "2015-01-01" @default.
• W3146028411 modified "2023-09-24" @default.
• W3146028411 title "Effect of fibulin-5 on adhesion, migration and invasion of hepatocellular carcinoma cells via an integrin-dependent mechanism" @default.
• W3146028411 hasPublicationYear "2015" @default.
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