FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3146038801> ?p ?o ?g. }

• W3146038801 endingPage "565" @default.
• W3146038801 startingPage "560" @default.
• W3146038801 abstract "Genetic factors are involved in the aetiology of Alzheimer's disease (AD) in 25-40% of the cases. In some cases AD clearly segregates as an autosomal dominant trait in families. Three genes have been identified which, when mutated, cause AD: the Abeta amyloid precursor protein gene (APP), and the presenilin-1 (PSEN1) and presenilin-2 (PSEN2) genes. Together, these mutations are responsible for 30-50% of the cases with autosomal dominant AD, and for about 5% of AD in general. In cases where the inheritance pattern is unclear and in sporadic cases the epsilon4 allele of the apolipoprotein E gene (APOE) has been identified as a major risk factor contributing to the pathogenesis of AD in about 20% of the cases. Although mutations in the known genes are a rare cause of AD they are useful for the purposes of presymptomatic diagnostics in autosomal dominant AD families that segregate these mutations. Also, the identification of these genes and mutations has been extremely important to the recent evolution in the understanding of the biology of the disease. However, other causative and risk genes are involved in AD and need to be identified in order to fully elucidate the biology of AD. This will ultimately lead to the development of effective therapies for this major disease." @default.
• W3146038801 created "2021-04-13" @default.
• W3146038801 creator A5039639102 @default.
• W3146038801 creator A5088006851 @default.
• W3146038801 date "1998-01-01" @default.
• W3146038801 modified "2023-10-12" @default.
• W3146038801 title "Molecular genetics of Alzheimer's disease" @default.
• W3146038801 cites W1537950723 @default.
• W3146038801 cites W1856257340 @default.
• W3146038801 cites W1965496447 @default.
• W3146038801 cites W1973118540 @default.
• W3146038801 cites W1978566291 @default.
• W3146038801 cites W1981744647 @default.
• W3146038801 cites W1999631936 @default.
• W3146038801 cites W1999902101 @default.
• W3146038801 cites W2002199806 @default.
• W3146038801 cites W2005681172 @default.
• W3146038801 cites W2005899728 @default.
• W3146038801 cites W2006014092 @default.
• W3146038801 cites W2006409771 @default.
• W3146038801 cites W2006623537 @default.
• W3146038801 cites W2011199056 @default.
• W3146038801 cites W2011924331 @default.
• W3146038801 cites W2016537454 @default.
• W3146038801 cites W2019251951 @default.
• W3146038801 cites W2020460543 @default.
• W3146038801 cites W2021181758 @default.
• W3146038801 cites W2027190021 @default.
• W3146038801 cites W2027926991 @default.
• W3146038801 cites W2029205666 @default.
• W3146038801 cites W2033356439 @default.
• W3146038801 cites W2033559242 @default.
• W3146038801 cites W2037851765 @default.
• W3146038801 cites W2039482551 @default.
• W3146038801 cites W2039651233 @default.
• W3146038801 cites W2042879498 @default.
• W3146038801 cites W2045153164 @default.
• W3146038801 cites W2046209489 @default.
• W3146038801 cites W2053152816 @default.
• W3146038801 cites W2056046302 @default.
• W3146038801 cites W2058723245 @default.
• W3146038801 cites W2063272219 @default.
• W3146038801 cites W2064093411 @default.
• W3146038801 cites W2070008559 @default.
• W3146038801 cites W2070068402 @default.
• W3146038801 cites W2070654470 @default.
• W3146038801 cites W2072682191 @default.
• W3146038801 cites W2073806885 @default.
• W3146038801 cites W2078957302 @default.
• W3146038801 cites W2081998222 @default.
• W3146038801 cites W2083633251 @default.
• W3146038801 cites W2090271811 @default.
• W3146038801 cites W2090390963 @default.
• W3146038801 cites W2092343129 @default.
• W3146038801 cites W2095745901 @default.
• W3146038801 cites W2098546816 @default.
• W3146038801 cites W2101077392 @default.
• W3146038801 cites W2121823413 @default.
• W3146038801 cites W2135475959 @default.
• W3146038801 cites W2139818289 @default.
• W3146038801 cites W2144429901 @default.
• W3146038801 cites W2147029696 @default.
• W3146038801 cites W2148236278 @default.
• W3146038801 cites W2152410944 @default.
• W3146038801 cites W2152681705 @default.
• W3146038801 cites W2156941821 @default.
• W3146038801 cites W2167260484 @default.
• W3146038801 cites W2168688177 @default.
• W3146038801 cites W2169848984 @default.
• W3146038801 cites W2170724596 @default.
• W3146038801 cites W4246743115 @default.
• W3146038801 cites W4247498777 @default.
• W3146038801 cites W4323284467 @default.
• W3146038801 doi "https://doi.org/10.3109/07853899809002605" @default.
• W3146038801 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9920359" @default.
• W3146038801 hasPublicationYear "1998" @default.
• W3146038801 type Work @default.
• W3146038801 sameAs 3146038801 @default.
• W3146038801 citedByCount "129" @default.
• W3146038801 countsByYear W31460388012012 @default.
• W3146038801 countsByYear W31460388012013 @default.
• W3146038801 countsByYear W31460388012014 @default.
• W3146038801 countsByYear W31460388012015 @default.
• W3146038801 countsByYear W31460388012016 @default.
• W3146038801 countsByYear W31460388012017 @default.
• W3146038801 countsByYear W31460388012019 @default.
• W3146038801 countsByYear W31460388012021 @default.
• W3146038801 countsByYear W31460388012023 @default.
• W3146038801 crossrefType "journal-article" @default.
• W3146038801 hasAuthorship W3146038801A5039639102 @default.
• W3146038801 hasAuthorship W3146038801A5088006851 @default.
• W3146038801 hasConcept C104317684 @default.
• W3146038801 hasConcept C142724271 @default.
• W3146038801 hasConcept C175344181 @default.
• W3146038801 hasConcept C180754005 @default.
• W3146038801 hasConcept C204315192 @default.
• W3146038801 hasConcept C2776485563 @default.
• W3146038801 hasConcept C2779134260 @default.

• next