FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3154367087> ?p ?o ?g. }

• W3154367087 abstract "Colorectal cancer (CRC) is a leading cause of cancer-related deaths worldwide. Early detection of CRC can significantly reduce its mortality rate. Current method of CRC diagnosis relies on the invasive endoscopy. Non-invasive assays including fecal occult blood testing (FOBT) and fecal immunological test (FIT) are compromised by low sensitivity and specificity, especially at early stages. Thus, a non-invasive and accurate approach for CRC screening would be highly desirable.A new qPCR-based assay combining the simultaneous detection of the DNA methylation status of ten candidate genes was used to examine plasma samples from 56 normal controls, 6 hyperplastic polys, 9 non-advanced adenomas (NAAs), 22 advanced adenomas (AAs) and 175 CRC patients, using 10 ng of cfDNA. We further built a logistic regression model for CRC diagnosis. We tested ten candidate methylation markers including twist1, vav3-as1, fbn1, c9orf50, sfmbt2, kcnq5, fam72c, itga4, kcnj12 and znf132. All markers showed moderate diagnostic performance with AUCs ranging from 0.726 to 0.815. Moreover, a 4-marker model, comprised of two previously reported markers (c9orf50 and twist1) and two novel ones (kcnj12 and znf132), demonstrated high performance for detecting colorectal cancer in an independent validation set (N = 69) with an overall AUC of 0.911 [95% confidence interval (CI) 0.834-0.988], sensitivity of 0.800 [95% CI 0.667-0.933] and specificity of 0.971 [95% CI 0.914-1.000]. The stage-stratified sensitivity of the model was 0.455 [95% CI 0.227-0.682], 0.667 [95% CI 0.289-1.000], 0.800 [95% CI 0.449-1.000], 0.800 [95% CI 0.449-1.000] and 0.842 [95% CI 0.678-1.000] for advanced adenoma and CRC stage I-IV, respectively.kcnj12 and znf132 are two novel methylation biomarkers for CRC diagnosis. The 4-marker methylation model provides a new non-invasive choice for CRC screening and interception." @default.
• W3154367087 created "2021-04-26" @default.
• W3154367087 creator A5015376105 @default.
• W3154367087 creator A5021687717 @default.
• W3154367087 creator A5029901918 @default.
• W3154367087 creator A5033020983 @default.
• W3154367087 creator A5034280778 @default.
• W3154367087 creator A5041027601 @default.
• W3154367087 creator A5042998865 @default.
• W3154367087 creator A5052509964 @default.
• W3154367087 creator A5057715969 @default.
• W3154367087 creator A5074895670 @default.
• W3154367087 creator A5077357809 @default.
• W3154367087 creator A5090657616 @default.
• W3154367087 date "2021-04-23" @default.
• W3154367087 modified "2023-10-17" @default.
• W3154367087 title "Sensitive detection of colorectal cancer in peripheral blood by a novel methylation assay" @default.
• W3154367087 cites W1639623904 @default.
• W3154367087 cites W1972787690 @default.
• W3154367087 cites W1980255492 @default.
• W3154367087 cites W1990118688 @default.
• W3154367087 cites W1997821617 @default.
• W3154367087 cites W2028382049 @default.
• W3154367087 cites W2046673558 @default.
• W3154367087 cites W2072363552 @default.
• W3154367087 cites W2140127918 @default.
• W3154367087 cites W2153230866 @default.
• W3154367087 cites W2232858624 @default.
• W3154367087 cites W2290471774 @default.
• W3154367087 cites W2416574815 @default.
• W3154367087 cites W2418753881 @default.
• W3154367087 cites W2521119549 @default.
• W3154367087 cites W2552138686 @default.
• W3154367087 cites W2552581434 @default.
• W3154367087 cites W2617455688 @default.
• W3154367087 cites W2621163719 @default.
• W3154367087 cites W2622388981 @default.
• W3154367087 cites W2754712980 @default.
• W3154367087 cites W2805885226 @default.
• W3154367087 cites W2809038982 @default.
• W3154367087 cites W2902949290 @default.
• W3154367087 cites W2905331035 @default.
• W3154367087 cites W2909240409 @default.
• W3154367087 cites W2936878306 @default.
• W3154367087 cites W2968078248 @default.
• W3154367087 cites W2983668961 @default.
• W3154367087 cites W3003086109 @default.
• W3154367087 cites W3009963727 @default.
• W3154367087 cites W3035087615 @default.
• W3154367087 cites W3119826188 @default.
• W3154367087 doi "https://doi.org/10.1186/s13148-021-01076-8" @default.
• W3154367087 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8066866" @default.
• W3154367087 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33892797" @default.
• W3154367087 hasPublicationYear "2021" @default.
• W3154367087 type Work @default.
• W3154367087 sameAs 3154367087 @default.
• W3154367087 citedByCount "17" @default.
• W3154367087 countsByYear W31543670872021 @default.
• W3154367087 countsByYear W31543670872022 @default.
• W3154367087 countsByYear W31543670872023 @default.
• W3154367087 crossrefType "journal-article" @default.
• W3154367087 hasAuthorship W3154367087A5015376105 @default.
• W3154367087 hasAuthorship W3154367087A5021687717 @default.
• W3154367087 hasAuthorship W3154367087A5029901918 @default.
• W3154367087 hasAuthorship W3154367087A5033020983 @default.
• W3154367087 hasAuthorship W3154367087A5034280778 @default.
• W3154367087 hasAuthorship W3154367087A5041027601 @default.
• W3154367087 hasAuthorship W3154367087A5042998865 @default.
• W3154367087 hasAuthorship W3154367087A5052509964 @default.
• W3154367087 hasAuthorship W3154367087A5057715969 @default.
• W3154367087 hasAuthorship W3154367087A5074895670 @default.
• W3154367087 hasAuthorship W3154367087A5077357809 @default.
• W3154367087 hasAuthorship W3154367087A5090657616 @default.
• W3154367087 hasBestOaLocation W31543670871 @default.
• W3154367087 hasConcept C104317684 @default.
• W3154367087 hasConcept C121608353 @default.
• W3154367087 hasConcept C126322002 @default.
• W3154367087 hasConcept C143998085 @default.
• W3154367087 hasConcept C146357865 @default.
• W3154367087 hasConcept C150194340 @default.
• W3154367087 hasConcept C151730666 @default.
• W3154367087 hasConcept C151956035 @default.
• W3154367087 hasConcept C190727270 @default.
• W3154367087 hasConcept C2778435480 @default.
• W3154367087 hasConcept C2779158730 @default.
• W3154367087 hasConcept C33288867 @default.
• W3154367087 hasConcept C44249647 @default.
• W3154367087 hasConcept C526805850 @default.
• W3154367087 hasConcept C54355233 @default.
• W3154367087 hasConcept C71924100 @default.
• W3154367087 hasConcept C76318530 @default.
• W3154367087 hasConcept C86803240 @default.
• W3154367087 hasConcept C90924648 @default.
• W3154367087 hasConceptScore W3154367087C104317684 @default.
• W3154367087 hasConceptScore W3154367087C121608353 @default.
• W3154367087 hasConceptScore W3154367087C126322002 @default.
• W3154367087 hasConceptScore W3154367087C143998085 @default.
• W3154367087 hasConceptScore W3154367087C146357865 @default.
• W3154367087 hasConceptScore W3154367087C150194340 @default.
• W3154367087 hasConceptScore W3154367087C151730666 @default.

• next