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- W3156991280 abstract "The eradication of Pseudomonas aeruginosa in cystic fibrosis patients has become continuously difficult due to its increased resistance to treatments. This study assessed the efficacy of free and liposomal gentamicin and erythromycin, combined with Phenylalanine arginine beta-naphthylamide (PABN), a broad-spectrum efflux pump inhibitor, against P. aeruginosa isolates. Liposomes were prepared and characterized for their sizes and encapsulation efficiencies. The antimicrobial activities of formulations were determined by the microbroth dilution method. Their activity on P. aeruginosa biofilms was assessed, and the effect of sub-inhibitory concentrations on bacterial virulence factors, quorum sensing (QS) signals and bacterial motility was also evaluated. The average diameters of liposomes were 562.67 ± 33.74 nm for gentamicin and 3086.35 ± 553.95 nm for erythromycin, with encapsulation efficiencies of 13.89 ± 1.54% and 51.58 ± 2.84%, respectively. Liposomes and PABN combinations potentiated antibiotics by reducing minimum inhibitory and bactericidal concentrations by 4–32 fold overall. The formulations significantly inhibited biofilm formation and differentially attenuated virulence factor production as well as motility. Unexpectedly, QS signal production was not affected by treatments. Taken together, the results indicate that PABN shows potential as an adjuvant of liposomal macrolides and aminoglycosides in the management of lung infections in cystic fibrosis patients." @default.
- W3156991280 created "2021-04-26" @default.
- W3156991280 creator A5052584761 @default.
- W3156991280 creator A5067980345 @default.
- W3156991280 date "2021-04-18" @default.
- W3156991280 modified "2023-10-18" @default.
- W3156991280 title "The Impact of an Efflux Pump Inhibitor on the Activity of Free and Liposomal Antibiotics against Pseudomonas aeruginosa" @default.
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- W3156991280 doi "https://doi.org/10.3390/pharmaceutics13040577" @default.
- W3156991280 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8072581" @default.
- W3156991280 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33919624" @default.
- W3156991280 hasPublicationYear "2021" @default.
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