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• W3161170422 abstract "The normal variability in breath size and frequency results in breath-to-breath variability of end-tidal PCO 2 (P ET CO 2 ), the measured variable, and arterial partial pressure of carbon dioxide (PaCO 2 ), the independent variable affecting cerebral blood flow (CBF). This study examines the effect of variability in PaCO 2 on the pattern of resting-state functional MRI (rs-fMRI) connectivity. A region of interest (ROI)-to-ROI and Seed-to-Voxel first-level bivariate correlation, hemodynamic response function (hrf)-weighted analysis for measuring rs-fMRI connectivity was performed during two resting-state conditions: (a) normal breathing associated with breath-to-breath variation in PaCO 2 (poikilocapnia), and (b) normal breathing with breath-to-breath variability of P ET CO 2 dampened using sequential rebreathing (isocapnia). End-tidal PCO 2 (P ET CO 2 ) was used as a measurable surrogate for fluctuations of PaCO 2 . During poikilocapnia, enhanced functional connections were found between the cerebellum and inferior frontal and supramarginal gyrus (SG), visual cortex and occipital fusiform gyrus; and between the primary visual network (PVN) and the hippocampal formation. During isocapnia, these associations were not seen, rather enhanced functional connections were identified in the corticostriatal pathway between the putamen and intracalacarine cortex, supracalcarine cortex (SCC), and precuneus cortex. We conclude that vascular responses to variations in P ET CO 2 , account for at least some of the observed resting state synchronization of blood oxygenation level-dependent (BOLD) signals." @default.
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• W3161170422 date "2021-05-13" @default.
• W3161170422 modified "2023-10-14" @default.
• W3161170422 title "The Effect of CO2 on Resting-State Functional Connectivity: Isocapnia vs. Poikilocapnia" @default.
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• W3161170422 doi "https://doi.org/10.3389/fphys.2021.639782" @default.
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