Matches in SemOpenAlex for { <https://semopenalex.org/work/W3166018908> ?p ?o ?g. }
- W3166018908 endingPage "206" @default.
- W3166018908 startingPage "199" @default.
- W3166018908 abstract "Methotrexate (MTX), an antifolate drug, is extensively prescribed for patients suffering from diseases like cancer, psoriasis, neoplasms, and rheumatoid arthritis. Despite its effectiveness, MTX sometimes finds limited application because its undesirable side effects, including hepatic or renal impairment, bone marrow toxicity and gastrointestinal mucosal injury. Squalene, a highly unsaturated isoprenoid compound, isolated from shark liver oil has great potential in neutralizing the damaging effects triggered by free radicals. Therefore, in this study, the protective role of dietary squalene supplementation on oxidative stress induced by methotrexate in experimental rats was evaluated. A significant reduction was displayed in the activities of catalase (CAT) and superoxide dismutase (SOD) in MTX-intoxicated groups compared to other groups. Similarly, the activities of glutathione dependant enzymes (GPx and GST) and reduced glutathione (GSH) in MTX-induced groups were shown to be lower compared to the untreated control. Increased LPO (lipid peroxide) level was found in MTX-intoxicated groups compared to other groups. In addition, alterations in the levels of liver marker enzymes like AST, ALP, ALT, and LDH were noticed in MTX intoxicated groups compared to other groups. Biochemical results were confirmed by the histopathological examination of liver sections. In conclusion, the result obtained in the present study proposes that squalene exerts antioxidant activity and is capable of ameliorating oxidative stress and liver injury induced by MTX." @default.
- W3166018908 created "2021-06-22" @default.
- W3166018908 creator A5005370130 @default.
- W3166018908 creator A5005394140 @default.
- W3166018908 creator A5007360163 @default.
- W3166018908 creator A5052248704 @default.
- W3166018908 creator A5087378634 @default.
- W3166018908 creator A5088838461 @default.
- W3166018908 date "2021-04-10" @default.
- W3166018908 modified "2023-10-16" @default.
- W3166018908 title "Antioxidant and hepatoprotective property of squalene for counteracting the oxidative damage induced by methotrex- ate in experimental rats" @default.
- W3166018908 cites W1508021342 @default.
- W3166018908 cites W1560955538 @default.
- W3166018908 cites W1581414347 @default.
- W3166018908 cites W1750690213 @default.
- W3166018908 cites W1775749144 @default.
- W3166018908 cites W1911137613 @default.
- W3166018908 cites W1964439071 @default.
- W3166018908 cites W1968855358 @default.
- W3166018908 cites W1975126034 @default.
- W3166018908 cites W1983310681 @default.
- W3166018908 cites W1992814520 @default.
- W3166018908 cites W1994950096 @default.
- W3166018908 cites W1996307147 @default.
- W3166018908 cites W2001165391 @default.
- W3166018908 cites W2002498988 @default.
- W3166018908 cites W2004105134 @default.
- W3166018908 cites W2006174622 @default.
- W3166018908 cites W2006370393 @default.
- W3166018908 cites W2019798386 @default.
- W3166018908 cites W2027411662 @default.
- W3166018908 cites W2030193512 @default.
- W3166018908 cites W2032536428 @default.
- W3166018908 cites W2037871192 @default.
- W3166018908 cites W2040200462 @default.
- W3166018908 cites W2056842005 @default.
- W3166018908 cites W2059973183 @default.
- W3166018908 cites W2068045145 @default.
- W3166018908 cites W2074604807 @default.
- W3166018908 cites W2076032177 @default.
- W3166018908 cites W2080474577 @default.
- W3166018908 cites W2081519860 @default.
- W3166018908 cites W2082107344 @default.
- W3166018908 cites W2088304084 @default.
- W3166018908 cites W2090754320 @default.
- W3166018908 cites W2091403015 @default.
- W3166018908 cites W2099197622 @default.
- W3166018908 cites W2104647183 @default.
- W3166018908 cites W2113421153 @default.
- W3166018908 cites W2116446961 @default.
- W3166018908 cites W2163536007 @default.
- W3166018908 cites W2507638238 @default.
- W3166018908 cites W2767752678 @default.
- W3166018908 cites W2783685245 @default.
- W3166018908 doi "https://doi.org/10.14232/abs.2020.2.199-206" @default.
- W3166018908 hasPublicationYear "2021" @default.
- W3166018908 type Work @default.
- W3166018908 sameAs 3166018908 @default.
- W3166018908 citedByCount "2" @default.
- W3166018908 countsByYear W31660189082022 @default.
- W3166018908 crossrefType "journal-article" @default.
- W3166018908 hasAuthorship W3166018908A5005370130 @default.
- W3166018908 hasAuthorship W3166018908A5005394140 @default.
- W3166018908 hasAuthorship W3166018908A5007360163 @default.
- W3166018908 hasAuthorship W3166018908A5052248704 @default.
- W3166018908 hasAuthorship W3166018908A5087378634 @default.
- W3166018908 hasAuthorship W3166018908A5088838461 @default.
- W3166018908 hasBestOaLocation W31660189081 @default.
- W3166018908 hasConcept C126322002 @default.
- W3166018908 hasConcept C181199279 @default.
- W3166018908 hasConcept C185592680 @default.
- W3166018908 hasConcept C2775838275 @default.
- W3166018908 hasConcept C2776151105 @default.
- W3166018908 hasConcept C2776637226 @default.
- W3166018908 hasConcept C2776703722 @default.
- W3166018908 hasConcept C2778004101 @default.
- W3166018908 hasConcept C2778760513 @default.
- W3166018908 hasConcept C2778979269 @default.
- W3166018908 hasConcept C2781059491 @default.
- W3166018908 hasConcept C2993790521 @default.
- W3166018908 hasConcept C538909803 @default.
- W3166018908 hasConcept C55493867 @default.
- W3166018908 hasConcept C71924100 @default.
- W3166018908 hasConcept C98274493 @default.
- W3166018908 hasConceptScore W3166018908C126322002 @default.
- W3166018908 hasConceptScore W3166018908C181199279 @default.
- W3166018908 hasConceptScore W3166018908C185592680 @default.
- W3166018908 hasConceptScore W3166018908C2775838275 @default.
- W3166018908 hasConceptScore W3166018908C2776151105 @default.
- W3166018908 hasConceptScore W3166018908C2776637226 @default.
- W3166018908 hasConceptScore W3166018908C2776703722 @default.
- W3166018908 hasConceptScore W3166018908C2778004101 @default.
- W3166018908 hasConceptScore W3166018908C2778760513 @default.
- W3166018908 hasConceptScore W3166018908C2778979269 @default.
- W3166018908 hasConceptScore W3166018908C2781059491 @default.
- W3166018908 hasConceptScore W3166018908C2993790521 @default.
- W3166018908 hasConceptScore W3166018908C538909803 @default.
- W3166018908 hasConceptScore W3166018908C55493867 @default.