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• W3169961211 endingPage "100732" @default.
• W3169961211 startingPage "100732" @default.
• W3169961211 abstract "4‑Acetylantroquinonol B (4-AAQB), as a kind of ubiquinone extracted from Antrodia cinnamomea ( A. cinnamomea ), has anticancer bioactivity. In this work, the deep liquid fermentation method was used to cultivate A. cinnamomea . After the medium compositions were optimized, the yield of 4-AAQB reached 11.05 mg/L in 20 days, about 6.9 times higher than the level from the initial medium. And fructose was found as the optimum carbon source for 4-AAQB accumulation. The two-stage cultivation method was thus developed for the fermentation process and was proven to be efficient for the improvement of cell growth combined with the immobilization of the mycelium on a fiber net. The production of 4-AAQB reached 16.3 mg/L in a 5 L fermentor. These data demonstrated that it was a feasible method for the production of 4-AAQB and provided a potential way for the production of natural active compounds by A. cinnamomea at an industrial scale. Establishment of the two-stage cultivation method for production of 4-AAQB by from Antrodia cinnamomea . • A two-stage culture method was developed for the cultivation of A. cinnamomea . • A mycelium immobilized method was first used to cultivate A. cinnamomea . • A high yield of 4-AAQB with a preferable biomass of A. cinnamomea was obtained." @default.
• W3169961211 created "2021-06-22" @default.
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• W3169961211 date "2021-09-01" @default.
• W3169961211 modified "2023-09-23" @default.
• W3169961211 title "Efficient production of 4-Acetylantroquinonol B from Antrodia cinnamomea through two-stage carbon source coordination optimization" @default.
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• W3169961211 doi "https://doi.org/10.1016/j.biteb.2021.100732" @default.
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