FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3173405280> ?p ?o ?g. }

• W3173405280 endingPage "3080" @default.
• W3173405280 startingPage "3069" @default.
• W3173405280 abstract "Abstract Background Immune checkpoint inhibitors (ICIs) can cause serious immune-related adverse events (irAEs). This study aimed to identify risk factors for all types of irAEs induced by ICIs in patients with non-small-cell lung cancer (NSCLC), by systematic review and meta-analyses. Methods A systematic search was performed in Pubmed, Embase and Web of Science by two independent reviewers. Studies were selected that included patients with NSCLC and evaluated characteristics of patients with and without irAEs induced by ICIs. Quality and risk of bias of the selected studies were assessed. Random effects meta-analyses were conducted to estimate pooled odds ratios (ORs) for risk factors of developing all type of irAEs, and separately for pneumonitis, interstitial lung disease and severe irAEs. With the objective of exploring sources of heterogeneity, stratified analyses were performed by quality and region. Results 25 studies met the inclusion criteria. In total, the data of 6696 patients were pooled. 33 different risk factors for irAEs were reported. irAEs of interest were reported for 1653 (25%) of the patients. Risk factors related to the development of irAEs were: C-reactive protein, neutrophil lymphocyte ratio (NLR), use of PD-1 inhibitor, high PD-L1 expression, an active or former smoking status, ground glass attenuation, and a better treatment response. Conclusion The identified risk factors for the development of these irAEs are mostly related to the alteration of the immune system, proinflammatory states and loss of immunological self-tolerance. Patients identified as having a higher risk for irAEs should be monitored more closely." @default.
• W3173405280 created "2021-07-05" @default.
• W3173405280 creator A5006978040 @default.
• W3173405280 creator A5014696143 @default.
• W3173405280 creator A5041553825 @default.
• W3173405280 creator A5050915012 @default.
• W3173405280 creator A5078862785 @default.
• W3173405280 creator A5091882944 @default.
• W3173405280 date "2021-06-30" @default.
• W3173405280 modified "2023-10-18" @default.
• W3173405280 title "Risk factors for adverse events induced by immune checkpoint inhibitors in patients with non-small-cell lung cancer: a systematic review and meta-analysis" @default.
• W3173405280 cites W1430642159 @default.
• W3173405280 cites W1642362876 @default.
• W3173405280 cites W2082977560 @default.
• W3173405280 cites W2138537778 @default.
• W3173405280 cites W2259730793 @default.
• W3173405280 cites W2265285917 @default.
• W3173405280 cites W2410849341 @default.
• W3173405280 cites W2569499583 @default.
• W3173405280 cites W2594032648 @default.
• W3173405280 cites W2736166064 @default.
• W3173405280 cites W2743419024 @default.
• W3173405280 cites W2753065806 @default.
• W3173405280 cites W2786816161 @default.
• W3173405280 cites W2794195501 @default.
• W3173405280 cites W2803216659 @default.
• W3173405280 cites W2805354595 @default.
• W3173405280 cites W2810424622 @default.
• W3173405280 cites W2888030212 @default.
• W3173405280 cites W2889646458 @default.
• W3173405280 cites W2891486030 @default.
• W3173405280 cites W2893321040 @default.
• W3173405280 cites W2895543265 @default.
• W3173405280 cites W2898004937 @default.
• W3173405280 cites W2903883219 @default.
• W3173405280 cites W2904303287 @default.
• W3173405280 cites W2908431216 @default.
• W3173405280 cites W2910245285 @default.
• W3173405280 cites W2912822337 @default.
• W3173405280 cites W2943701399 @default.
• W3173405280 cites W2945447513 @default.
• W3173405280 cites W2947942089 @default.
• W3173405280 cites W2955654502 @default.
• W3173405280 cites W2965778028 @default.
• W3173405280 cites W2967398918 @default.
• W3173405280 cites W2970160545 @default.
• W3173405280 cites W2979284539 @default.
• W3173405280 cites W2986033296 @default.
• W3173405280 cites W2986118997 @default.
• W3173405280 cites W2988124258 @default.
• W3173405280 cites W3001449972 @default.
• W3173405280 cites W3007744508 @default.
• W3173405280 cites W3009099064 @default.
• W3173405280 cites W3010153830 @default.
• W3173405280 cites W3015929829 @default.
• W3173405280 cites W3036354112 @default.
• W3173405280 cites W3037506839 @default.
• W3173405280 cites W3048608605 @default.
• W3173405280 cites W3081088465 @default.
• W3173405280 cites W3083281449 @default.
• W3173405280 cites W3084363340 @default.
• W3173405280 cites W3088867352 @default.
• W3173405280 cites W3089749215 @default.
• W3173405280 cites W3095154565 @default.
• W3173405280 cites W3111826742 @default.
• W3173405280 doi "https://doi.org/10.1007/s00262-021-02996-3" @default.
• W3173405280 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8505368" @default.
• W3173405280 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34195862" @default.
• W3173405280 hasPublicationYear "2021" @default.
• W3173405280 type Work @default.
• W3173405280 sameAs 3173405280 @default.
• W3173405280 citedByCount "26" @default.
• W3173405280 countsByYear W31734052802021 @default.
• W3173405280 countsByYear W31734052802022 @default.
• W3173405280 countsByYear W31734052802023 @default.
• W3173405280 crossrefType "journal-article" @default.
• W3173405280 hasAuthorship W3173405280A5006978040 @default.
• W3173405280 hasAuthorship W3173405280A5014696143 @default.
• W3173405280 hasAuthorship W3173405280A5041553825 @default.
• W3173405280 hasAuthorship W3173405280A5050915012 @default.
• W3173405280 hasAuthorship W3173405280A5078862785 @default.
• W3173405280 hasAuthorship W3173405280A5091882944 @default.
• W3173405280 hasBestOaLocation W31734052801 @default.
• W3173405280 hasConcept C126322002 @default.
• W3173405280 hasConcept C143998085 @default.
• W3173405280 hasConcept C156957248 @default.
• W3173405280 hasConcept C197934379 @default.
• W3173405280 hasConcept C2776256026 @default.
• W3173405280 hasConcept C2777714996 @default.
• W3173405280 hasConcept C2779524853 @default.
• W3173405280 hasConcept C71924100 @default.
• W3173405280 hasConcept C95190672 @default.
• W3173405280 hasConceptScore W3173405280C126322002 @default.
• W3173405280 hasConceptScore W3173405280C143998085 @default.
• W3173405280 hasConceptScore W3173405280C156957248 @default.
• W3173405280 hasConceptScore W3173405280C197934379 @default.
• W3173405280 hasConceptScore W3173405280C2776256026 @default.
• W3173405280 hasConceptScore W3173405280C2777714996 @default.

• next