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- W3174920750 endingPage "437" @default.
- W3174920750 startingPage "405" @default.
- W3174920750 abstract "Natural killer (NK) cells can kill cells without prior sensitization. They eliminate tumors via antibody-dependent cell-mediated cytotoxicity (ADCC) or through NK cell receptor-ligand interactions that trigger intrinsic NK cytotoxicity. When the human leukocyte antigen (HLA)-killer immunoglobulin receptor (KIR) mismatch was discovered as one of the mechanisms of intrinsic NK cytotoxicity, adoptive NK cell transfers moved into the spotlight of cellular therapies. Emerging technology to perform KIR and HLA genotyping of donors and recipients allowed the selection of suitable donors for this purpose. The adoptive transfer of NK cells has since evolved into an investigational therapy for hematologic and solid malignancies of childhood. Although early studies have demonstrated that HLA–KIR-mismatched donor transplants extend survival in patients with acute myeloid leukemia, the indication and activity of adoptive HLA–KIR-mismatched NK cells remain under active investigation. Current challenges include short persistence and limited efficacy of adoptive NK cells in vivo, features that may be attributed to suboptimal activation and expansion ex vivo. Therefore, research efforts are geared toward refining the procedures to manipulate donor NK cells in culture and identifying combinations to further enhance their efficacy. This chapter reviews the current state of adoptive NK cell therapies in children with cancer and highlights challenges and ongoing attempts to improve these strategies." @default.
- W3174920750 created "2021-07-05" @default.
- W3174920750 creator A5034374604 @default.
- W3174920750 creator A5036154152 @default.
- W3174920750 date "2021-01-01" @default.
- W3174920750 modified "2023-10-16" @default.
- W3174920750 title "Adoptive NK cell therapies in children with cancer: Clinical challenges and future possibilities" @default.
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