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- W3176173017 abstract "Introduction: Heat-labile enterotoxins (HLTs) and their cognate ganglioside receptors have been extensively studied because of their therapeutic potential. Gangliosides play arole in modulating effector cells of the immune system, and HLTs provide a novel means for stimulating ganglioside-mediated responses in immunocompetent cells.Areas covered: To evaluate the mechanisms of HLT adjuvanticity, a systemic literature review was performed using relevant keyword searches of the PubMed database, accessing literature published as recently as late 2020. Since HLTs bind to specific ganglioside receptors on immunocytes, they can act as regulators via stimulation or tapering of immune responses from associated signal transduction events. Binding of HLTs to gangliosides can increase proliferation of T-cells, increase cytokine release, augment mucosal/systemic antibody responses, and increase the effectiveness of antigen presenting cells. Subunit components also independently stimulate certain immune responses. Mutant forms of HLTs have potent immunomodulatory effects without the toxicity associated with holotoxins.Expert opinion: HLTs have been the subject of abundant research exploring their use as vaccine adjuvants, in the treatment of autoimmune conditions, in cancer therapy, and for weight loss, proving that these molecules are promising tools in the field of immunotherapy." @default.
- W3176173017 created "2021-07-05" @default.
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- W3176173017 date "2021-07-06" @default.
- W3176173017 modified "2023-10-16" @default.
- W3176173017 title "Immunomodulatory regulation by heat-labile enterotoxins and potential therapeutic applications" @default.
- W3176173017 cites W1509067395 @default.
- W3176173017 cites W1564861448 @default.
- W3176173017 cites W1577004966 @default.
- W3176173017 cites W1583355211 @default.
- W3176173017 cites W1613230534 @default.
- W3176173017 cites W1819784342 @default.
- W3176173017 cites W1861867405 @default.
- W3176173017 cites W187359374 @default.
- W3176173017 cites W1895518456 @default.
- W3176173017 cites W1928648264 @default.
- W3176173017 cites W1945653345 @default.
- W3176173017 cites W1963847109 @default.
- W3176173017 cites W1968669248 @default.
- W3176173017 cites W1968706116 @default.
- W3176173017 cites W1969393357 @default.
- W3176173017 cites W1975094495 @default.
- W3176173017 cites W1977331253 @default.
- W3176173017 cites W1988275003 @default.
- W3176173017 cites W1990575346 @default.
- W3176173017 cites W1991116187 @default.
- W3176173017 cites W1992660251 @default.
- W3176173017 cites W1996701281 @default.
- W3176173017 cites W1997113784 @default.
- W3176173017 cites W2006073788 @default.
- W3176173017 cites W2010890754 @default.
- W3176173017 cites W2011303793 @default.
- W3176173017 cites W2019288241 @default.
- W3176173017 cites W2026624543 @default.
- W3176173017 cites W2029038578 @default.
- W3176173017 cites W2031351176 @default.
- W3176173017 cites W2033533993 @default.
- W3176173017 cites W2036472856 @default.
- W3176173017 cites W2038907391 @default.
- W3176173017 cites W2053069441 @default.
- W3176173017 cites W2056178732 @default.
- W3176173017 cites W2058071434 @default.
- W3176173017 cites W2058421813 @default.
- W3176173017 cites W2060902946 @default.
- W3176173017 cites W2061582443 @default.
- W3176173017 cites W2067441694 @default.
- W3176173017 cites W2085889988 @default.
- W3176173017 cites W2090226585 @default.
- W3176173017 cites W2093038908 @default.
- W3176173017 cites W2097633205 @default.
- W3176173017 cites W2100305420 @default.
- W3176173017 cites W2100484298 @default.
- W3176173017 cites W2101972962 @default.
- W3176173017 cites W2104084202 @default.
- W3176173017 cites W2105433670 @default.
- W3176173017 cites W2108985104 @default.
- W3176173017 cites W2113501117 @default.
- W3176173017 cites W2116118728 @default.
- W3176173017 cites W2116686692 @default.
- W3176173017 cites W2124864045 @default.
- W3176173017 cites W2125625534 @default.
- W3176173017 cites W2127742089 @default.
- W3176173017 cites W2128963767 @default.
- W3176173017 cites W2133080338 @default.
- W3176173017 cites W2138385535 @default.
- W3176173017 cites W2144305638 @default.
- W3176173017 cites W2154247885 @default.
- W3176173017 cites W2155391532 @default.
- W3176173017 cites W2156878114 @default.
- W3176173017 cites W2157852790 @default.
- W3176173017 cites W2158281384 @default.
- W3176173017 cites W2159101101 @default.
- W3176173017 cites W2160105482 @default.
- W3176173017 cites W2160854753 @default.
- W3176173017 cites W2161061586 @default.
- W3176173017 cites W2162425865 @default.
- W3176173017 cites W2164225397 @default.
- W3176173017 cites W2168789654 @default.
- W3176173017 cites W2170409747 @default.
- W3176173017 cites W2170464539 @default.
- W3176173017 cites W2199136876 @default.
- W3176173017 cites W2210125585 @default.
- W3176173017 cites W2264749978 @default.
- W3176173017 cites W2318156479 @default.
- W3176173017 cites W2326210766 @default.
- W3176173017 cites W2466427704 @default.
- W3176173017 cites W2560160864 @default.
- W3176173017 cites W2560754495 @default.
- W3176173017 cites W2593612531 @default.
- W3176173017 cites W2601704121 @default.
- W3176173017 cites W2755823067 @default.