Matches in SemOpenAlex for { <https://semopenalex.org/work/W3191672273> ?p ?o ?g. }
- W3191672273 endingPage "133" @default.
- W3191672273 startingPage "125" @default.
- W3191672273 abstract "The pharmaceutical industry and clinical trials have been revolutionized mesenchymal stem cell–based therapeutics. However, the pharmacokinetics of transplanted cells has been little characterized in their target tissues under healthy or disease condition. A quantitative polymerase chain reaction analytical method with matrix effect was developed to track the biodistribution of human mesenchymal stem cells in normal mice and those with Concanavalin A (Con A)–induced liver injury. Mesenchymal stem/stromal cell (MSC) disposition in blood and different organs were compared, and relevant pharmacokinetic parameters were calculated. Human MSCs (hMSCs) and mouse MSCs (mMSCs) displayed a very similar pharmacokinetic profile in all tested doses: about 95% of the detected hMSCs accumulated in the lung and 3% in the liver, and almost negligible cells were detected in other tissues. A significant double peak of hMSC concentration emerged in the lung within 1–2 hours after intravenous injection, as with mMSCs. Prazosin, a vasodilator, could eliminate the second peak in the lung and increase its C<sub>max</sub> and area under the concentration-time curve (AUC) by 10% in the first 2 hours. The injury caused by Con A was significantly reduced by hMSCs, and the C<sub>max</sub> and AUC<sub>0–8</sub> (AUC from time 0 to 8 hours) of cells in the injured liver decreased by 54 and 50%, respectively. The C<sub>max</sub> and AUC would be improved with the alleviation of congestion through the administration of heparin. The study provides a novel insight into the pharmacokinetics of exogenous MSCs in normal and Con A–induced liver injury mice, which provides a framework for optimizing cell transplantation. <h3>SIGNIFICANCE STATEMENT</h3> Mesenchymal stem/stromal cells (MSCs) are known for their potential as regenerative therapies in treating several diseases, but an insufficient understanding of the pharmacokinetics of MSCs restricts their future application. The current study was the first to elucidate the pharmacokinetics and possible factors, including dosage, species, and derived sources, in a systematic way. The study further revealed that Concanavalin A–induced liver injury significantly prevented cells from entering the injury site, which could be reversed by the diminished congestion achieved by heparin." @default.
- W3191672273 created "2021-08-16" @default.
- W3191672273 creator A5005185022 @default.
- W3191672273 creator A5006884460 @default.
- W3191672273 creator A5013052796 @default.
- W3191672273 creator A5015588857 @default.
- W3191672273 creator A5035464945 @default.
- W3191672273 creator A5054418515 @default.
- W3191672273 creator A5058030526 @default.
- W3191672273 creator A5059304852 @default.
- W3191672273 creator A5063688023 @default.
- W3191672273 creator A5067132196 @default.
- W3191672273 creator A5069190300 @default.
- W3191672273 creator A5085219611 @default.
- W3191672273 date "2021-08-09" @default.
- W3191672273 modified "2023-10-09" @default.
- W3191672273 title "Define Mesenchymal Stem Cell from Its Fate: Biodisposition of Human Mesenchymal Stem Cells in Normal and Concanavalin A–Induced Liver Injury Mice" @default.
- W3191672273 cites W1617326991 @default.
- W3191672273 cites W1692461747 @default.
- W3191672273 cites W1798012002 @default.
- W3191672273 cites W1954710919 @default.
- W3191672273 cites W1967217261 @default.
- W3191672273 cites W1971218073 @default.
- W3191672273 cites W1977604024 @default.
- W3191672273 cites W1989823385 @default.
- W3191672273 cites W1998883576 @default.
- W3191672273 cites W2007201869 @default.
- W3191672273 cites W2018028722 @default.
- W3191672273 cites W2019123554 @default.
- W3191672273 cites W2021916724 @default.
- W3191672273 cites W2033284503 @default.
- W3191672273 cites W2035000104 @default.
- W3191672273 cites W2048448240 @default.
- W3191672273 cites W2060754957 @default.
- W3191672273 cites W2066165581 @default.
- W3191672273 cites W2067494596 @default.
- W3191672273 cites W2080169614 @default.
- W3191672273 cites W2082536791 @default.
- W3191672273 cites W2082958780 @default.
- W3191672273 cites W2097227226 @default.
- W3191672273 cites W2149186767 @default.
- W3191672273 cites W2182766838 @default.
- W3191672273 cites W2260863227 @default.
- W3191672273 cites W2277593669 @default.
- W3191672273 cites W2337861353 @default.
- W3191672273 cites W2469725217 @default.
- W3191672273 cites W2567404056 @default.
- W3191672273 cites W2573721304 @default.
- W3191672273 cites W2742187740 @default.
- W3191672273 cites W2768641609 @default.
- W3191672273 cites W2770867911 @default.
- W3191672273 cites W2775757975 @default.
- W3191672273 cites W2801646996 @default.
- W3191672273 cites W2805892376 @default.
- W3191672273 cites W2907088267 @default.
- W3191672273 cites W2945976146 @default.
- W3191672273 cites W2952322235 @default.
- W3191672273 cites W2992079273 @default.
- W3191672273 cites W3016810232 @default.
- W3191672273 cites W3042430718 @default.
- W3191672273 doi "https://doi.org/10.1124/jpet.121.000607" @default.
- W3191672273 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34373354" @default.
- W3191672273 hasPublicationYear "2021" @default.
- W3191672273 type Work @default.
- W3191672273 sameAs 3191672273 @default.
- W3191672273 citedByCount "4" @default.
- W3191672273 countsByYear W31916722732022 @default.
- W3191672273 countsByYear W31916722732023 @default.
- W3191672273 crossrefType "journal-article" @default.
- W3191672273 hasAuthorship W3191672273A5005185022 @default.
- W3191672273 hasAuthorship W3191672273A5006884460 @default.
- W3191672273 hasAuthorship W3191672273A5013052796 @default.
- W3191672273 hasAuthorship W3191672273A5015588857 @default.
- W3191672273 hasAuthorship W3191672273A5035464945 @default.
- W3191672273 hasAuthorship W3191672273A5054418515 @default.
- W3191672273 hasAuthorship W3191672273A5058030526 @default.
- W3191672273 hasAuthorship W3191672273A5059304852 @default.
- W3191672273 hasAuthorship W3191672273A5063688023 @default.
- W3191672273 hasAuthorship W3191672273A5067132196 @default.
- W3191672273 hasAuthorship W3191672273A5069190300 @default.
- W3191672273 hasAuthorship W3191672273A5085219611 @default.
- W3191672273 hasBestOaLocation W31916722731 @default.
- W3191672273 hasConcept C112705442 @default.
- W3191672273 hasConcept C142724271 @default.
- W3191672273 hasConcept C185592680 @default.
- W3191672273 hasConcept C19869320 @default.
- W3191672273 hasConcept C198826908 @default.
- W3191672273 hasConcept C202751555 @default.
- W3191672273 hasConcept C2776637226 @default.
- W3191672273 hasConcept C2777807558 @default.
- W3191672273 hasConcept C28328180 @default.
- W3191672273 hasConcept C55493867 @default.
- W3191672273 hasConcept C71924100 @default.
- W3191672273 hasConcept C76318530 @default.
- W3191672273 hasConcept C86803240 @default.
- W3191672273 hasConcept C95444343 @default.
- W3191672273 hasConcept C98274493 @default.
- W3191672273 hasConceptScore W3191672273C112705442 @default.