FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3193782007> ?p ?o ?g. }

• W3193782007 endingPage "197" @default.
• W3193782007 startingPage "187" @default.
• W3193782007 abstract "Psoriasis is a multifactorial chronic inflammatory disorder resulting by the interplay of genetics, the immune system and the environment. It is characterized by the hyperproliferation of epithelial cells, generating red, itchy psoriatic plaques which have no cure but have great negative impact in patients’ life. Although corticosteroids or vitamin D analogs might help recovery to some extent, there is yet no total cure for the disease. In this study, we sought to generate three-dimensional (3D) stress-related psoriatic skin spheroids with the screening of the potential efficacy of a β2-adrenergic receptor agonist, salbutamol. 3D Culture spheroids with human dermal fibroblasts (HDF), human epithelial keratinocytes (HEK) and human monocytic cell line (THP-1) were generated as a representative model of skin and the protocol of stress-related modelling was conducted. The efficacy of the drug salbutamol was evaluated by the changes in mRNA and protein expression levels of selected genes, as well as by several metabolic assays. We developed a method for culturing spherical organoid models of psoriasis in vitro. We tested the potential theurapetic effects of salbutamol on psoriasis spheroids. Spheroids treated with salbutamol indicated the effictiveness of the treatment. 3D spheroid system was found partially efficient for mimicking the physiological features of psoriasis in vitro. This present work may be a starting point for future investigation as it is the first to generate a stress-related psoriatic model and first to try a β2 agonist as a potential treatment option. Considering the effects and suitability of topical application of salbutamol, its efficacy should not be underestimated and should be investigated further for translating this knowledge into clinics." @default.
• W3193782007 created "2021-08-30" @default.
• W3193782007 creator A5003789869 @default.
• W3193782007 creator A5011220323 @default.
• W3193782007 creator A5015621791 @default.
• W3193782007 creator A5045841491 @default.
• W3193782007 creator A5058599954 @default.
• W3193782007 date "2021-10-15" @default.
• W3193782007 modified "2023-09-26" @default.
• W3193782007 title "SALBUTAMOL AMELIORATES THE PHENOTYPE OF THE SKIN INFLAMMATORY DISEASE PSORIASIS ACCORDING TO SKIN SPHEROID MODELS" @default.
• W3193782007 cites W1178274363 @default.
• W3193782007 cites W1580233091 @default.
• W3193782007 cites W1961179371 @default.
• W3193782007 cites W1976464405 @default.
• W3193782007 cites W1982078500 @default.
• W3193782007 cites W2013921608 @default.
• W3193782007 cites W2014237749 @default.
• W3193782007 cites W2014613937 @default.
• W3193782007 cites W2020760332 @default.
• W3193782007 cites W2033032062 @default.
• W3193782007 cites W2038013281 @default.
• W3193782007 cites W2042222655 @default.
• W3193782007 cites W2048910178 @default.
• W3193782007 cites W2065638849 @default.
• W3193782007 cites W2068472762 @default.
• W3193782007 cites W2073675282 @default.
• W3193782007 cites W2083364957 @default.
• W3193782007 cites W2093236527 @default.
• W3193782007 cites W2104971908 @default.
• W3193782007 cites W2114229735 @default.
• W3193782007 cites W2125665263 @default.
• W3193782007 cites W2152457676 @default.
• W3193782007 cites W2342271048 @default.
• W3193782007 cites W2408483783 @default.
• W3193782007 cites W2472642463 @default.
• W3193782007 cites W2538117928 @default.
• W3193782007 cites W2585011132 @default.
• W3193782007 cites W2593514818 @default.
• W3193782007 cites W2599881072 @default.
• W3193782007 cites W2604219750 @default.
• W3193782007 cites W2613397542 @default.
• W3193782007 cites W2622237865 @default.
• W3193782007 cites W2729022949 @default.
• W3193782007 cites W2752721387 @default.
• W3193782007 cites W2768590742 @default.
• W3193782007 cites W2772985695 @default.
• W3193782007 cites W2775663182 @default.
• W3193782007 cites W2797770630 @default.
• W3193782007 cites W2872661560 @default.
• W3193782007 cites W2899510124 @default.
• W3193782007 cites W2955712242 @default.
• W3193782007 cites W2975402758 @default.
• W3193782007 cites W3007256553 @default.
• W3193782007 cites W4235338639 @default.
• W3193782007 doi "https://doi.org/10.23902/trkjnat.878417" @default.
• W3193782007 hasPublicationYear "2021" @default.
• W3193782007 type Work @default.
• W3193782007 sameAs 3193782007 @default.
• W3193782007 citedByCount "0" @default.
• W3193782007 crossrefType "journal-article" @default.
• W3193782007 hasAuthorship W3193782007A5003789869 @default.
• W3193782007 hasAuthorship W3193782007A5011220323 @default.
• W3193782007 hasAuthorship W3193782007A5015621791 @default.
• W3193782007 hasAuthorship W3193782007A5045841491 @default.
• W3193782007 hasAuthorship W3193782007A5058599954 @default.
• W3193782007 hasBestOaLocation W31937820071 @default.
• W3193782007 hasConcept C126322002 @default.
• W3193782007 hasConcept C170493617 @default.
• W3193782007 hasConcept C175369904 @default.
• W3193782007 hasConcept C202751555 @default.
• W3193782007 hasConcept C203014093 @default.
• W3193782007 hasConcept C2776042228 @default.
• W3193782007 hasConcept C2777394947 @default.
• W3193782007 hasConcept C2777459323 @default.
• W3193782007 hasConcept C2778938600 @default.
• W3193782007 hasConcept C2780564577 @default.
• W3193782007 hasConcept C54355233 @default.
• W3193782007 hasConcept C55493867 @default.
• W3193782007 hasConcept C71924100 @default.
• W3193782007 hasConcept C81885089 @default.
• W3193782007 hasConcept C86803240 @default.
• W3193782007 hasConcept C98274493 @default.
• W3193782007 hasConceptScore W3193782007C126322002 @default.
• W3193782007 hasConceptScore W3193782007C170493617 @default.
• W3193782007 hasConceptScore W3193782007C175369904 @default.
• W3193782007 hasConceptScore W3193782007C202751555 @default.
• W3193782007 hasConceptScore W3193782007C203014093 @default.
• W3193782007 hasConceptScore W3193782007C2776042228 @default.
• W3193782007 hasConceptScore W3193782007C2777394947 @default.
• W3193782007 hasConceptScore W3193782007C2777459323 @default.
• W3193782007 hasConceptScore W3193782007C2778938600 @default.
• W3193782007 hasConceptScore W3193782007C2780564577 @default.
• W3193782007 hasConceptScore W3193782007C54355233 @default.
• W3193782007 hasConceptScore W3193782007C55493867 @default.
• W3193782007 hasConceptScore W3193782007C71924100 @default.
• W3193782007 hasConceptScore W3193782007C81885089 @default.
• W3193782007 hasConceptScore W3193782007C86803240 @default.
• W3193782007 hasConceptScore W3193782007C98274493 @default.

• next