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• W3195730672 endingPage "102788" @default.
• W3195730672 startingPage "102788" @default.
• W3195730672 abstract "Alcohol use disorder (AUD) is associated with brain-wide gray matter (GM) reduction, but the frontocerebellar circuit seems specifically affected by chronic alcohol consumption. T1 weighted MRI data from 38 AUD patients at one month of sobriety and three months later and from 25 controls were analyzed using voxel-based morphometry (VBM) and a graph theory approach (GTA). We investigated the degree to which the frontocerebellar circuit's integration within the brain's GM network architecture was altered by AUD-related GM volume loss. The VBM analyses did not reveal significant GM volume differences between relapsers and abstainers at either timepoint, but future relapsers at both timepoints had significantly less GM than controls in the frontocerebellar circuit. Abstainers, who at baseline also showed the most pronounced GM loss in the thalamus, showed a significant circuit-wide GM increase with inter-scan abstinence. The post-hoc GTAs revealed a persistent diffuse global atrophy in both AUD groups at follow-up relative to controls and different recovery patterns in the two AUD groups. Our findings suggest that future relapsers do not just present with a more severe expression of the same AUD consequences than abstainers, but that AUD affects the frontocerebellar circuit differently in relapsers and abstainers." @default.
• W3195730672 created "2021-08-30" @default.
• W3195730672 creator A5060873703 @default.
• W3195730672 creator A5077461136 @default.
• W3195730672 date "2021-01-01" @default.
• W3195730672 modified "2023-10-17" @default.
• W3195730672 title "Frontocerebellar gray matter plasticity in alcohol use disorder linked to abstinence" @default.
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• W3195730672 doi "https://doi.org/10.1016/j.nicl.2021.102788" @default.
• W3195730672 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8387922" @default.
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• W3195730672 hasPublicationYear "2021" @default.
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