FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3196800974> ?p ?o ?g. }

• W3196800974 endingPage "133" @default.
• W3196800974 startingPage "126" @default.
• W3196800974 abstract "The grading of gliomas based on histological features has been a subject of debate for several decades. A consensus has not yet been reached because of technical limitations and inter-observer variations. While the traditional grading system has failed to stratify the risk of IDH-mutant astrocytoma, canonical histological and proliferative markers may be applicable to the risk stratification of IDH-wild-type astrocytoma. Numerous studies have examined molecular markers in order to obtain more clinically relevant information that will improve the risk stratification of gliomas. The CDKN2A/B homozygous deletion for IDH-mutant astrocytoma and the following three criteria for IDH-wild-type astrocytoma: the concurrent gain of whole chromosome 7 and loss of whole chromosome 10, TERT promoter mutations, and EGFR amplification, were identified as independent molecular markers of the worst clinical outcomes. Therefore, the 2021 World Health Organization (WHO) Classification of Tumors of the Central Nervous System adopted these molecular markers into the revised grading criteria of IDH-mutant and -wild-type astrocytoma, respectively, as a grading system within tumor types. Of note, several recent studies have shown that some low-grade IDH-wild-type astrocytoma lacking both the molecular glioblastoma signature and genetic alterations typical of pediatric-type gliomas may demonstrate a relatively indolent clinical course, suggesting the existence of lower-grade adult IDH-wild-type astrocytoma. In terms of oligodendroglioma, IDH-mutant, and 1p/19q codeleted, consistent makers that predict poor outcomes have not yet been identified, and, thus, the current criteria have remained unchanged. Molecular testing to fulfill the revised WHO criteria is, however, not always available worldwide, and in that case, an integrated diagnosis combining all available complementary information is highly recommended. This review discusses controversial issues surrounding legacy grading systems and newly identified potential genetic markers of adult diffuse gliomas and provides perspectives on future grading systems. The 5th edition of WHO Classification of Tumors of the Central Nervous System adopted new molecular markers into the revised grading criteria of IDH-mutant and -wild-type astrocytoma, i.e., the CDKN2A/B homozygous deletion for IDH-mutant astrocytoma and the following three criteria for IDH-wild-type astrocytoma: the concurrent gain of whole chromosome 7 and loss of whole chromosome 10, TERT promoter mutations, and EGFR amplification, as independent molecular markers of the highest grade." @default.
• W3196800974 created "2021-09-13" @default.
• W3196800974 creator A5034279785 @default.
• W3196800974 date "2022-02-01" @default.
• W3196800974 modified "2023-10-18" @default.
• W3196800974 title "Grading of adult diffuse gliomas according to the 2021 WHO Classification of Tumors of the Central Nervous System" @default.
• W3196800974 cites W1530069278 @default.
• W3196800974 cites W1605643841 @default.
• W3196800974 cites W1763993939 @default.
• W3196800974 cites W1812256879 @default.
• W3196800974 cites W1881100945 @default.
• W3196800974 cites W1893588436 @default.
• W3196800974 cites W1943407880 @default.
• W3196800974 cites W1952429608 @default.
• W3196800974 cites W2013346068 @default.
• W3196800974 cites W2013816626 @default.
• W3196800974 cites W2021162007 @default.
• W3196800974 cites W2028906953 @default.
• W3196800974 cites W2040827479 @default.
• W3196800974 cites W2070603556 @default.
• W3196800974 cites W2072179218 @default.
• W3196800974 cites W2078972833 @default.
• W3196800974 cites W2085277801 @default.
• W3196800974 cites W2089745742 @default.
• W3196800974 cites W2094447223 @default.
• W3196800974 cites W2105100844 @default.
• W3196800974 cites W2105528101 @default.
• W3196800974 cites W2107007091 @default.
• W3196800974 cites W2112625058 @default.
• W3196800974 cites W2123151813 @default.
• W3196800974 cites W2128152209 @default.
• W3196800974 cites W2131117209 @default.
• W3196800974 cites W2148977460 @default.
• W3196800974 cites W2154526619 @default.
• W3196800974 cites W2160382843 @default.
• W3196800974 cites W2164650078 @default.
• W3196800974 cites W2263206910 @default.
• W3196800974 cites W2266860362 @default.
• W3196800974 cites W2287840016 @default.
• W3196800974 cites W2320688130 @default.
• W3196800974 cites W2322088975 @default.
• W3196800974 cites W2326550986 @default.
• W3196800974 cites W2366536035 @default.
• W3196800974 cites W2513843238 @default.
• W3196800974 cites W2559580777 @default.
• W3196800974 cites W2580208371 @default.
• W3196800974 cites W2610120607 @default.
• W3196800974 cites W2618667624 @default.
• W3196800974 cites W2739147644 @default.
• W3196800974 cites W2744277165 @default.
• W3196800974 cites W2745262591 @default.
• W3196800974 cites W2745769521 @default.
• W3196800974 cites W2748467653 @default.
• W3196800974 cites W2787816121 @default.
• W3196800974 cites W2788183929 @default.
• W3196800974 cites W2789875411 @default.
• W3196800974 cites W2792102603 @default.
• W3196800974 cites W2792738569 @default.
• W3196800974 cites W2793930465 @default.
• W3196800974 cites W2802818144 @default.
• W3196800974 cites W2808774136 @default.
• W3196800974 cites W2811036728 @default.
• W3196800974 cites W2891763428 @default.
• W3196800974 cites W2896684230 @default.
• W3196800974 cites W2897033359 @default.
• W3196800974 cites W2912875190 @default.
• W3196800974 cites W2921106016 @default.
• W3196800974 cites W2921239832 @default.
• W3196800974 cites W2925419682 @default.
• W3196800974 cites W2929168862 @default.
• W3196800974 cites W2930192997 @default.
• W3196800974 cites W2944716937 @default.
• W3196800974 cites W2945471311 @default.
• W3196800974 cites W2951388646 @default.
• W3196800974 cites W2952034571 @default.
• W3196800974 cites W2952513725 @default.
• W3196800974 cites W2956589719 @default.
• W3196800974 cites W2962982912 @default.
• W3196800974 cites W2965023466 @default.
• W3196800974 cites W2974861223 @default.
• W3196800974 cites W2981544544 @default.
• W3196800974 cites W2984912591 @default.
• W3196800974 cites W3005858078 @default.
• W3196800974 cites W3007397778 @default.
• W3196800974 cites W3013118155 @default.
• W3196800974 cites W3016756297 @default.
• W3196800974 cites W3021306676 @default.
• W3196800974 cites W3034140733 @default.
• W3196800974 cites W3047571993 @default.
• W3196800974 cites W3048012348 @default.
• W3196800974 cites W3092871279 @default.
• W3196800974 cites W3098926804 @default.
• W3196800974 cites W3113537649 @default.
• W3196800974 cites W3115366055 @default.
• W3196800974 cites W3118554413 @default.
• W3196800974 cites W3121943121 @default.
• W3196800974 cites W3135218460 @default.
• W3196800974 cites W3147266715 @default.

• next