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• W3199888936 abstract "ABSTRACT Parvalbumin-expressing interneurons (PV neurons) maintain inhibitory control of local circuits implicated in behavioral responses to environmental stressors. However, the roles of molecular and cellular adaptations in PV neurons in stress susceptibility or resilience have not been clearly established. Here, we show behavioral outcomes of chronic social defeat stress (CSDS) are mediated by differential neuronal activity and gene expression in hippocampal PV neurons in mice. Using in vivo electrophysiology and chemogenetics, we find increased PV neuronal activity in the ventral dentate gyrus is required and sufficient for behavioral susceptibility to CSDS. PV neuron-selective translational profiling indicates mitochondrial oxidative phosphorylation is the most significantly altered pathway in stress-susceptible versus resilient mice. Among differentially expressed genes associated with stress-susceptibility and resilience, we find Ahnak, an endogenous regulator of L-type calcium channels which are implicated in the regulation of mitochondrial function and gene expression. Notably, Ahnak deletion in PV neurons impedes behavioral susceptibility to CSDS. Altogether, these findings indicate behavioral effects of chronic stress can be controlled by selective modulation of PV neuronal activity or a regulator of L-type calcium signaling in PV neurons." @default.
• W3199888936 created "2021-09-27" @default.
• W3199888936 creator A5012669440 @default.
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• W3199888936 date "2021-09-15" @default.
• W3199888936 modified "2023-09-27" @default.
• W3199888936 title "Molecular and cellular adaptations in hippocampal parvalbumin neurons mediate behavioral responses to chronic social stress" @default.
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• W3199888936 cites W2049220190 @default.
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• W3199888936 cites W2057017838 @default.
• W3199888936 cites W2057165036 @default.
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• W3199888936 doi "https://doi.org/10.1101/2021.09.14.459024" @default.
• W3199888936 hasPublicationYear "2021" @default.
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