FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3202288424> ?p ?o ?g. }

• W3202288424 endingPage "4899" @default.
• W3202288424 startingPage "4899" @default.
• W3202288424 abstract "Mechanistic TCP (tumor control probability) models exist that account for possible re-sensitization of an initially hypoxic tumor during treatment. This phenomenon potentially explains the better outcome of a 28-day vs 14-day treatment schedule of HDR (high dose rate) brachytherapy of low- to intermediate-risk prostate cancer as recently reported.A TCP model accounting for tumor re-sensitization developed earlier is used to analyze the reported clinical data. In order to analyze clinical data using individual TCP model, TCP distributions are constructed assuming inter-individual spread in radio-sensitivity.Population radio-sensitivity parameter values are found that result in TCP population values which are close to the reported ones. Using the estimated population parameters, two hypothetical regimens are investigated that are shorter than the ones used clinically. The impact of the re-sensitization rate on the calculated treatment outcome is also investigated as is the anti-hypothesis that there is no re-sensitization during treatment.The carried out investigation shows that the observed clinical data cannot be described without assuming an initially hypoxic state of the tumor followed by re-oxygenation and, hence, re-sensitization. This phenomenon explains the better outcome of the prolonged treatment schedule compared to shorter regimens based on the fact that prostate cancer is a slowly repopulating tumor." @default.
• W3202288424 created "2021-10-11" @default.
• W3202288424 creator A5011844809 @default.
• W3202288424 creator A5033583059 @default.
• W3202288424 creator A5043704582 @default.
• W3202288424 creator A5046844909 @default.
• W3202288424 creator A5055790933 @default.
• W3202288424 creator A5061746429 @default.
• W3202288424 creator A5081673996 @default.
• W3202288424 date "2021-09-29" @default.
• W3202288424 modified "2023-09-27" @default.
• W3202288424 title "The Impact of Different Timing Schedules on Prostate HDR-Mono-Brachytherapy. A TCP Modeling Investigation" @default.
• W3202288424 cites W1955500944 @default.
• W3202288424 cites W1976496513 @default.
• W3202288424 cites W1981065559 @default.
• W3202288424 cites W1985894363 @default.
• W3202288424 cites W1991426014 @default.
• W3202288424 cites W2001875060 @default.
• W3202288424 cites W2009446017 @default.
• W3202288424 cites W2016557934 @default.
• W3202288424 cites W2027652813 @default.
• W3202288424 cites W2029303959 @default.
• W3202288424 cites W2077356383 @default.
• W3202288424 cites W2077679212 @default.
• W3202288424 cites W2089253822 @default.
• W3202288424 cites W2111685034 @default.
• W3202288424 cites W2122971048 @default.
• W3202288424 cites W2126785034 @default.
• W3202288424 cites W2133871729 @default.
• W3202288424 cites W2135238404 @default.
• W3202288424 cites W2157255230 @default.
• W3202288424 cites W2184797990 @default.
• W3202288424 cites W2199646096 @default.
• W3202288424 cites W2274463904 @default.
• W3202288424 cites W2511219591 @default.
• W3202288424 cites W2581655717 @default.
• W3202288424 cites W2598815466 @default.
• W3202288424 cites W2792868936 @default.
• W3202288424 cites W2828561204 @default.
• W3202288424 cites W2890650375 @default.
• W3202288424 cites W2946519178 @default.
• W3202288424 cites W2947504956 @default.
• W3202288424 cites W3150534430 @default.
• W3202288424 cites W3157583906 @default.
• W3202288424 cites W3158936206 @default.
• W3202288424 cites W4236549981 @default.
• W3202288424 doi "https://doi.org/10.3390/cancers13194899" @default.
• W3202288424 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8507871" @default.
• W3202288424 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34638379" @default.
• W3202288424 hasPublicationYear "2021" @default.
• W3202288424 type Work @default.
• W3202288424 sameAs 3202288424 @default.
• W3202288424 citedByCount "2" @default.
• W3202288424 countsByYear W32022884242022 @default.
• W3202288424 countsByYear W32022884242023 @default.
• W3202288424 crossrefType "journal-article" @default.
• W3202288424 hasAuthorship W3202288424A5011844809 @default.
• W3202288424 hasAuthorship W3202288424A5033583059 @default.
• W3202288424 hasAuthorship W3202288424A5043704582 @default.
• W3202288424 hasAuthorship W3202288424A5046844909 @default.
• W3202288424 hasAuthorship W3202288424A5055790933 @default.
• W3202288424 hasAuthorship W3202288424A5061746429 @default.
• W3202288424 hasAuthorship W3202288424A5081673996 @default.
• W3202288424 hasBestOaLocation W32022884241 @default.
• W3202288424 hasConcept C121608353 @default.
• W3202288424 hasConcept C126322002 @default.
• W3202288424 hasConcept C126894567 @default.
• W3202288424 hasConcept C143998085 @default.
• W3202288424 hasConcept C203014093 @default.
• W3202288424 hasConcept C2776217527 @default.
• W3202288424 hasConcept C2776235491 @default.
• W3202288424 hasConcept C2777416452 @default.
• W3202288424 hasConcept C2780192828 @default.
• W3202288424 hasConcept C2908647359 @default.
• W3202288424 hasConcept C509974204 @default.
• W3202288424 hasConcept C71924100 @default.
• W3202288424 hasConcept C99454951 @default.
• W3202288424 hasConceptScore W3202288424C121608353 @default.
• W3202288424 hasConceptScore W3202288424C126322002 @default.
• W3202288424 hasConceptScore W3202288424C126894567 @default.
• W3202288424 hasConceptScore W3202288424C143998085 @default.
• W3202288424 hasConceptScore W3202288424C203014093 @default.
• W3202288424 hasConceptScore W3202288424C2776217527 @default.
• W3202288424 hasConceptScore W3202288424C2776235491 @default.
• W3202288424 hasConceptScore W3202288424C2777416452 @default.
• W3202288424 hasConceptScore W3202288424C2780192828 @default.
• W3202288424 hasConceptScore W3202288424C2908647359 @default.
• W3202288424 hasConceptScore W3202288424C509974204 @default.
• W3202288424 hasConceptScore W3202288424C71924100 @default.
• W3202288424 hasConceptScore W3202288424C99454951 @default.
• W3202288424 hasFunder F4320321843 @default.
• W3202288424 hasIssue "19" @default.
• W3202288424 hasLocation W32022884241 @default.
• W3202288424 hasLocation W32022884242 @default.
• W3202288424 hasLocation W32022884243 @default.
• W3202288424 hasOpenAccess W3202288424 @default.
• W3202288424 hasPrimaryLocation W32022884241 @default.
• W3202288424 hasRelatedWork W1980245127 @default.

• next