FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3203878889> ?p ?o ?g. }

• W3203878889 abstract "Abstract Introduction SARS-CoV-2 infection increases the risk of secondary bacterial and fungal infections and contributes to adverse outcomes. The present study was undertaken to get better insights into the extent of secondary bacterial and fungal infections in Indian hospitalized patients and to assess how these alter the course of COVID-19 so that the control measures can be suggested. Methods This is a retrospective, multicentre study where data of all RT-PCR positive COVID-19 patients was accessed from Electronic Health Records (EHR) of a network of 10 hospitals across 5 North Indian states, admitted during the period from March 2020 to July 2021.The data included demographic profile of patients, clinical characteristics, laboratory parameters, treatment modalities, and outcome in those with secondary infections (SIs) and those without SIs. Spectrum of SIS was also studied in detail. Results Of 19852 RT-PCR positive SARS-CO2 patients admitted during the study period, 1940 (9.8%) patients developed SIs. Patients with SIs were 8 years older on average (median age 62.6 years versus 54.3 years; P<0.001) than those without SIs. The risk of SIs was significantly (p < 0.001) associated with age, severity of disease at admission, diabetes, ICU admission, and ventilator use. The most common site of infection was urinary tract infection (UTI) (41.7%), followed by blood stream infection (BSI) (30.8%), sputum/BAL/ET fluid (24.8%), and the least was pus/wound discharge (2.6%). As many as 13.4% had infections with more than organism and 34.1% patients had positive cultures from more than one site. Gram negative bacilli (GNB) were the commonest organisms (63.2%), followed by Gram positive cocci (GPC) (19.6%) and fungus (17.3%). Most of the patients with SIs were on multiple antimicrobials – the most commonly used were the BL-BLI for GNBs (76.9%) followed by carbapenems (57.7%), cephalosporins (53.9%) and antibiotics carbapenem resistant entreobacteriace (47.1%). The usage of emperical antibiotics for GPCs was in 58.9% and of antifungals in 56.9% of cases, and substantially more than the results obtained by culture. The average stay in hospital for patients with SIs was twice than those without SIs (median 13 days versus 7 days). The overall mortality in the group with SIs (40.3%) was more than 8 times of that in those without SIs (4.6%). Only 1.2% of SI patients with mild COVID-19 at presentation died, while 17.5% of those with moderate disease and 58.5% of those with severe COVID-19 died (P< 0.001). The mortality was highest in those with BSI (49.8%), closely followed by those with HAP (47.9%), and then UTI and SSTI (29.4% each). The mortality rate where only one microorganism was identified was 37.8% and rose to 56.3% in those with more than one microorganism. The mortality in cases with only one site of infection was 28.8%, which steeply rose to 62.5% in cases with multiple sites of infection. The mortality in diabetic patients with SIs was 45.2% while in non-diabetics it was 34.3% (p < 0.001). Conclusions Secondary bacterial and fungal infections can complicate the course of almost 10% of COVID-19 hospitalised patients. These patients tend to not only have a much longer stay in hospital, but also a higher requirement for oxygen and ICU care. The mortality in this group rises steeply by as much as 8 times. The group most vulnerable to this complication are those with more severe COVID-19 illness, elderly, and diabetic patients. Varying results in different studies suggest that a region or country specific guideline be developed for appropriate use of antibiotics and antifungals to prevent their overuse in such cases. Judicious empiric use of combination antimicrobials in this set of vulnerable COVID-19 patients can save lives." @default.
• W3203878889 created "2021-10-11" @default.
• W3203878889 creator A5000382259 @default.
• W3203878889 creator A5001052369 @default.
• W3203878889 creator A5001687221 @default.
• W3203878889 creator A5001879581 @default.
• W3203878889 creator A5002749837 @default.
• W3203878889 creator A5003392931 @default.
• W3203878889 creator A5003514168 @default.
• W3203878889 creator A5004311331 @default.
• W3203878889 creator A5004752542 @default.
• W3203878889 creator A5006034480 @default.
• W3203878889 creator A5006825886 @default.
• W3203878889 creator A5008457208 @default.
• W3203878889 creator A5008722966 @default.
• W3203878889 creator A5010563291 @default.
• W3203878889 creator A5010961217 @default.
• W3203878889 creator A5013372926 @default.
• W3203878889 creator A5014976532 @default.
• W3203878889 creator A5016538830 @default.
• W3203878889 creator A5017320935 @default.
• W3203878889 creator A5017638712 @default.
• W3203878889 creator A5017815445 @default.
• W3203878889 creator A5018079137 @default.
• W3203878889 creator A5018999745 @default.
• W3203878889 creator A5021246435 @default.
• W3203878889 creator A5023515125 @default.
• W3203878889 creator A5024213582 @default.
• W3203878889 creator A5024896947 @default.
• W3203878889 creator A5025726891 @default.
• W3203878889 creator A5025728200 @default.
• W3203878889 creator A5026048488 @default.
• W3203878889 creator A5026385737 @default.
• W3203878889 creator A5026668811 @default.
• W3203878889 creator A5027226376 @default.
• W3203878889 creator A5028330673 @default.
• W3203878889 creator A5028567944 @default.
• W3203878889 creator A5029384548 @default.
• W3203878889 creator A5030427021 @default.
• W3203878889 creator A5030813356 @default.
• W3203878889 creator A5031373672 @default.
• W3203878889 creator A5032870911 @default.
• W3203878889 creator A5033651822 @default.
• W3203878889 creator A5034057404 @default.
• W3203878889 creator A5034306575 @default.
• W3203878889 creator A5034679219 @default.
• W3203878889 creator A5035494052 @default.
• W3203878889 creator A5036732080 @default.
• W3203878889 creator A5036925130 @default.
• W3203878889 creator A5037647503 @default.
• W3203878889 creator A5037839110 @default.
• W3203878889 creator A5040394455 @default.
• W3203878889 creator A5041646423 @default.
• W3203878889 creator A5041863046 @default.
• W3203878889 creator A5042916578 @default.
• W3203878889 creator A5042948157 @default.
• W3203878889 creator A5043027170 @default.
• W3203878889 creator A5043341662 @default.
• W3203878889 creator A5043610060 @default.
• W3203878889 creator A5045136076 @default.
• W3203878889 creator A5045304008 @default.
• W3203878889 creator A5045628579 @default.
• W3203878889 creator A5051565145 @default.
• W3203878889 creator A5051790448 @default.
• W3203878889 creator A5052231995 @default.
• W3203878889 creator A5052474633 @default.
• W3203878889 creator A5053314574 @default.
• W3203878889 creator A5053531674 @default.
• W3203878889 creator A5056020671 @default.
• W3203878889 creator A5056622289 @default.
• W3203878889 creator A5056835129 @default.
• W3203878889 creator A5057011757 @default.
• W3203878889 creator A5057582034 @default.
• W3203878889 creator A5057699181 @default.
• W3203878889 creator A5058098493 @default.
• W3203878889 creator A5059081611 @default.
• W3203878889 creator A5062816046 @default.
• W3203878889 creator A5065399413 @default.
• W3203878889 creator A5065676870 @default.
• W3203878889 creator A5066314647 @default.
• W3203878889 creator A5067705014 @default.
• W3203878889 creator A5067798415 @default.
• W3203878889 creator A5067876812 @default.
• W3203878889 creator A5069416565 @default.
• W3203878889 creator A5069998908 @default.
• W3203878889 creator A5070462000 @default.
• W3203878889 creator A5071670998 @default.
• W3203878889 creator A5072213715 @default.
• W3203878889 creator A5072954640 @default.
• W3203878889 creator A5075448704 @default.
• W3203878889 creator A5075732995 @default.
• W3203878889 creator A5078729219 @default.
• W3203878889 creator A5084365038 @default.
• W3203878889 creator A5086389962 @default.
• W3203878889 creator A5086689433 @default.
• W3203878889 creator A5086946495 @default.
• W3203878889 creator A5086973752 @default.
• W3203878889 creator A5087463921 @default.
• W3203878889 creator A5087533792 @default.
• W3203878889 creator A5088895070 @default.

• next