Matches in SemOpenAlex for { <https://semopenalex.org/work/W3206026080> ?p ?o ?g. }
- W3206026080 endingPage "2804" @default.
- W3206026080 startingPage "2793" @default.
- W3206026080 abstract "Adeno-associated viruses (AAVs) are key vectors for gene therapy; thus, many aspects of their cell transduction pathway have been revealed in detail. However, the specific mechanisms AAV virions use to enter the host nucleus remain largely unresolved. We therefore aimed to reveal the structural interactions between the AAV capsid (Cap) protein and the nuclear transport protein importin alpha (IMPα). A putative nuclear localization sequence (NLS) in the virion protein 1 capsid protein of the porcine AAV Po1 was identified. This region was complexed with IMPα and a structure solved at 2.26 Å. This is the first time that an NLS of AAV Cap complexed with IMPα has been determined structurally. Our results support the findings that AAV capsids enter the nucleus through binding the nuclear import adapter IMPα." @default.
- W3206026080 created "2021-10-25" @default.
- W3206026080 creator A5029725982 @default.
- W3206026080 creator A5033763253 @default.
- W3206026080 creator A5063382999 @default.
- W3206026080 date "2021-11-01" @default.
- W3206026080 modified "2023-09-25" @default.
- W3206026080 title "Structural characterization of the porcine adeno‐associated virus Po1 capsid protein binding to the nuclear trafficking protein importin alpha" @default.
- W3206026080 cites W1500537600 @default.
- W3206026080 cites W1870505444 @default.
- W3206026080 cites W1911750425 @default.
- W3206026080 cites W1954356707 @default.
- W3206026080 cites W1966374792 @default.
- W3206026080 cites W1969271703 @default.
- W3206026080 cites W1987453834 @default.
- W3206026080 cites W2000217017 @default.
- W3206026080 cites W2002565864 @default.
- W3206026080 cites W2003847336 @default.
- W3206026080 cites W2005291427 @default.
- W3206026080 cites W2008289270 @default.
- W3206026080 cites W2009455163 @default.
- W3206026080 cites W2012715792 @default.
- W3206026080 cites W2018563196 @default.
- W3206026080 cites W2033490568 @default.
- W3206026080 cites W2047245819 @default.
- W3206026080 cites W2051913102 @default.
- W3206026080 cites W2052620131 @default.
- W3206026080 cites W2057126633 @default.
- W3206026080 cites W2059202997 @default.
- W3206026080 cites W2061013034 @default.
- W3206026080 cites W2062840171 @default.
- W3206026080 cites W2066313345 @default.
- W3206026080 cites W2079433334 @default.
- W3206026080 cites W2083392652 @default.
- W3206026080 cites W2089610358 @default.
- W3206026080 cites W2101428586 @default.
- W3206026080 cites W2101458827 @default.
- W3206026080 cites W2105017686 @default.
- W3206026080 cites W2106246537 @default.
- W3206026080 cites W2107586018 @default.
- W3206026080 cites W2108921801 @default.
- W3206026080 cites W2110035145 @default.
- W3206026080 cites W2111051741 @default.
- W3206026080 cites W2117637900 @default.
- W3206026080 cites W2120683337 @default.
- W3206026080 cites W2122191644 @default.
- W3206026080 cites W2122304523 @default.
- W3206026080 cites W2122994276 @default.
- W3206026080 cites W2124026197 @default.
- W3206026080 cites W2134160801 @default.
- W3206026080 cites W2136568935 @default.
- W3206026080 cites W2141236766 @default.
- W3206026080 cites W2144081223 @default.
- W3206026080 cites W2145365087 @default.
- W3206026080 cites W2147949826 @default.
- W3206026080 cites W2149678280 @default.
- W3206026080 cites W2154450422 @default.
- W3206026080 cites W2156187175 @default.
- W3206026080 cites W2156961771 @default.
- W3206026080 cites W2157098992 @default.
- W3206026080 cites W2163341755 @default.
- W3206026080 cites W2164625869 @default.
- W3206026080 cites W2168763653 @default.
- W3206026080 cites W2180229411 @default.
- W3206026080 cites W2321372052 @default.
- W3206026080 cites W2414645227 @default.
- W3206026080 cites W2520747219 @default.
- W3206026080 cites W2574320882 @default.
- W3206026080 cites W2611948882 @default.
- W3206026080 cites W2623463662 @default.
- W3206026080 cites W2752295055 @default.
- W3206026080 cites W2796959653 @default.
- W3206026080 cites W2890646021 @default.
- W3206026080 cites W2911914006 @default.
- W3206026080 cites W2913212173 @default.
- W3206026080 cites W2920220762 @default.
- W3206026080 cites W2921400628 @default.
- W3206026080 cites W2939251998 @default.
- W3206026080 cites W2965000423 @default.
- W3206026080 cites W2995820186 @default.
- W3206026080 cites W3016405424 @default.
- W3206026080 cites W3038595912 @default.
- W3206026080 cites W3088103984 @default.
- W3206026080 cites W3092811898 @default.
- W3206026080 cites W3108896277 @default.
- W3206026080 cites W3118755338 @default.
- W3206026080 cites W3125814759 @default.
- W3206026080 cites W3153630165 @default.
- W3206026080 cites W3187307462 @default.
- W3206026080 cites W4210675630 @default.
- W3206026080 doi "https://doi.org/10.1002/1873-3468.14209" @default.
- W3206026080 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34661283" @default.
- W3206026080 hasPublicationYear "2021" @default.
- W3206026080 type Work @default.
- W3206026080 sameAs 3206026080 @default.
- W3206026080 citedByCount "2" @default.
- W3206026080 countsByYear W32060260802023 @default.
- W3206026080 crossrefType "journal-article" @default.