FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3208195310> ?p ?o ?g. }

• W3208195310 endingPage "4633" @default.
• W3208195310 startingPage "4621" @default.
• W3208195310 abstract "Current study was conducted to design and screen a long-lasting Exendin-4 analog for treating type 2 diabetes via the novel strategy of albumin binding combined with thrombin enzymolysis. First, a series of fusion peptides, containing different albumin-binding tags, a determinate thrombin-cleavable linker and a native Exendin-4, were prepared via chemosynthesis for in vitro and in vivo characterization. Surface plasmon resonance assay, thrombin cleavage assay and plasma stability test were performed for screening the optimal HEX peptide with enhanced albumin-binding affinity, controlled-release as well as plasma stability. The in vivo anti-diabetic efficacies of the selected candidate were further assessed via both acute and chronic pharmacodynamic evaluation in diabetic model animals. HEX15 exhibited either the highest affinity for human serum albumin or the superior in vitro stability and controlled release of Exendin-4 among 21 HEX peptides. Glucose tolerance test and hypoglycemic duration assay both revealed the notably improved the glucose tolerance and prolonged normoglycemic duration, respectively, of diabetic mice after single treatment of HEX15. Furthermore, chronic dosing of HEX15 significantly ameliorated the manifestations of diabetes in the db/db mice, including body weight, food intake, glycometabolism as well as hyperlipemia. Interestingly, combination therapy of HEX15 and long non-coding RNA-ENST00000411554 notably accelerated the wound healing and improved foot ulcer symptoms in model rats with diabetic foot ulcers. In summary, based on the strategy of linking the heptapeptide tag and thrombin-based sustained release, a long-acting Exendin-4 analog, HEX15, holds potential to be developed as a drug for ameliorating T2D as well as diabetic complications." @default.
• W3208195310 created "2021-11-08" @default.
• W3208195310 creator A5002661071 @default.
• W3208195310 creator A5022015104 @default.
• W3208195310 creator A5031172404 @default.
• W3208195310 creator A5031653114 @default.
• W3208195310 creator A5070090368 @default.
• W3208195310 date "2022-02-21" @default.
• W3208195310 modified "2023-09-30" @default.
• W3208195310 title "Albumin-binding tag derived Exendin-4 analogue for treating hyperglycemia and diabetic complications" @default.
• W3208195310 cites W1573629907 @default.
• W3208195310 cites W1860382351 @default.
• W3208195310 cites W1975708697 @default.
• W3208195310 cites W1980700191 @default.
• W3208195310 cites W2012987104 @default.
• W3208195310 cites W2035776098 @default.
• W3208195310 cites W2041513202 @default.
• W3208195310 cites W2080622379 @default.
• W3208195310 cites W2088877201 @default.
• W3208195310 cites W2121597792 @default.
• W3208195310 cites W2162140339 @default.
• W3208195310 cites W2264307850 @default.
• W3208195310 cites W2588078961 @default.
• W3208195310 cites W2612322611 @default.
• W3208195310 cites W2620755219 @default.
• W3208195310 cites W2724823461 @default.
• W3208195310 cites W2735588562 @default.
• W3208195310 cites W2768268612 @default.
• W3208195310 cites W2793551948 @default.
• W3208195310 cites W2810664066 @default.
• W3208195310 cites W2901516736 @default.
• W3208195310 cites W2909248393 @default.
• W3208195310 cites W2920526722 @default.
• W3208195310 cites W2946642925 @default.
• W3208195310 cites W3006887594 @default.
• W3208195310 cites W56121288 @default.
• W3208195310 doi "https://doi.org/10.1080/21655979.2021.1995993" @default.
• W3208195310 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34696658" @default.
• W3208195310 hasPublicationYear "2022" @default.
• W3208195310 type Work @default.
• W3208195310 sameAs 3208195310 @default.
• W3208195310 citedByCount "0" @default.
• W3208195310 crossrefType "journal-article" @default.
• W3208195310 hasAuthorship W3208195310A5002661071 @default.
• W3208195310 hasAuthorship W3208195310A5022015104 @default.
• W3208195310 hasAuthorship W3208195310A5031172404 @default.
• W3208195310 hasAuthorship W3208195310A5031653114 @default.
• W3208195310 hasAuthorship W3208195310A5070090368 @default.
• W3208195310 hasBestOaLocation W32081953101 @default.
• W3208195310 hasConcept C126322002 @default.
• W3208195310 hasConcept C134018914 @default.
• W3208195310 hasConcept C150903083 @default.
• W3208195310 hasConcept C185592680 @default.
• W3208195310 hasConcept C202751555 @default.
• W3208195310 hasConcept C207001950 @default.
• W3208195310 hasConcept C2776125364 @default.
• W3208195310 hasConcept C2777292125 @default.
• W3208195310 hasConcept C2777858829 @default.
• W3208195310 hasConcept C2778144972 @default.
• W3208195310 hasConcept C55493867 @default.
• W3208195310 hasConcept C555293320 @default.
• W3208195310 hasConcept C71924100 @default.
• W3208195310 hasConcept C86803240 @default.
• W3208195310 hasConcept C89560881 @default.
• W3208195310 hasConcept C98274493 @default.
• W3208195310 hasConceptScore W3208195310C126322002 @default.
• W3208195310 hasConceptScore W3208195310C134018914 @default.
• W3208195310 hasConceptScore W3208195310C150903083 @default.
• W3208195310 hasConceptScore W3208195310C185592680 @default.
• W3208195310 hasConceptScore W3208195310C202751555 @default.
• W3208195310 hasConceptScore W3208195310C207001950 @default.
• W3208195310 hasConceptScore W3208195310C2776125364 @default.
• W3208195310 hasConceptScore W3208195310C2777292125 @default.
• W3208195310 hasConceptScore W3208195310C2777858829 @default.
• W3208195310 hasConceptScore W3208195310C2778144972 @default.
• W3208195310 hasConceptScore W3208195310C55493867 @default.
• W3208195310 hasConceptScore W3208195310C555293320 @default.
• W3208195310 hasConceptScore W3208195310C71924100 @default.
• W3208195310 hasConceptScore W3208195310C86803240 @default.
• W3208195310 hasConceptScore W3208195310C89560881 @default.
• W3208195310 hasConceptScore W3208195310C98274493 @default.
• W3208195310 hasIssue "3" @default.
• W3208195310 hasLocation W32081953101 @default.
• W3208195310 hasLocation W32081953102 @default.
• W3208195310 hasLocation W32081953103 @default.
• W3208195310 hasLocation W32081953104 @default.
• W3208195310 hasOpenAccess W3208195310 @default.
• W3208195310 hasPrimaryLocation W32081953101 @default.
• W3208195310 hasRelatedWork W1966504330 @default.
• W3208195310 hasRelatedWork W1979139803 @default.
• W3208195310 hasRelatedWork W1983855168 @default.
• W3208195310 hasRelatedWork W2029823099 @default.
• W3208195310 hasRelatedWork W2037631372 @default.
• W3208195310 hasRelatedWork W2040058909 @default.
• W3208195310 hasRelatedWork W2132898409 @default.
• W3208195310 hasRelatedWork W2748952813 @default.
• W3208195310 hasRelatedWork W2899084033 @default.
• W3208195310 hasRelatedWork W2014611610 @default.

• next