FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3210362920> ?p ?o ?g. }

• W3210362920 abstract "Abstract The importance of understanding the pharmacokinetic and therapeutic efficacy of nanoparticles (NPs) in chemotherapy and reviewing their application is highlighted and explained in this chapter. Pharmacokinetics (PK) is the study of dynamic movements of foreign chemicals during their passage through the body and as such encompasses the kinetics of absorption, distribution, metabolism, and excretion (ADME). Therefore, to understand and predict the in vivo fate of NPs in the body, more insights into the correlation between particle properties and interaction with the body are needed. The use of nanocarriers as drug delivery systems enables the application of drugs in particulate form, which distinctly changes the ADME profile of the active compound. NPs are used in therapeutic treatments, such as tissue regeneration therapy and antitumor immunotherapy, because NPs are effective delivery vehicles for proteins, nucleic acids, and other bioactive compounds. It is evident through this review that application of nanotechnology in drug delivery and medicine has paved new pathways and opened many doors for providing customizable and safer treatment options. To elucidate the biological functions of NPs, and for the development of NPs-based therapeutics, the PK of NP is important. The nanopharmacokinetic profile of particles is mainly influenced by the protein adsorption pattern, which in turn is determined by the physicochemical properties of the particles. Hence nanopharmacokinetics is the key to efficiently modulate and to optimize maximum drug delivery for obtaining safe and efficient nanomedicines in the future. NPs can be made of polymers, proteins, lipids, or metals. Nonmetallic NPs are the most advanced and currently approved nanoparticulate therapies in the market. Rapid advancement in research, especially in the arena of NPs with biological applications, has led to the development of new diagnostics and treatment prospects. In this chapter, we aim to summarize current knowledge about the PK and biodistribution of NP. The PK of exogenously administered NP is discussed based on the tissue distribution, types of cells taking up NP, and key molecules in the PK of NP. In addition, recent progresses in the methods for controlling the PK of NP are reviewed." @default.
• W3210362920 created "2021-11-08" @default.
• W3210362920 creator A5074686635 @default.
• W3210362920 date "2021-01-01" @default.
• W3210362920 modified "2023-10-16" @default.
• W3210362920 title "Nano-pharmacokinetics and cancer theranostics" @default.
• W3210362920 cites W1182092194 @default.
• W3210362920 cites W1564553363 @default.
• W3210362920 cites W1973881933 @default.
• W3210362920 cites W1975088956 @default.
• W3210362920 cites W1985508815 @default.
• W3210362920 cites W2020535635 @default.
• W3210362920 cites W2031460307 @default.
• W3210362920 cites W2039123138 @default.
• W3210362920 cites W2051379483 @default.
• W3210362920 cites W2053360422 @default.
• W3210362920 cites W2066936530 @default.
• W3210362920 cites W2074719284 @default.
• W3210362920 cites W2118435322 @default.
• W3210362920 cites W2137863506 @default.
• W3210362920 cites W2142504874 @default.
• W3210362920 cites W2145688027 @default.
• W3210362920 cites W2164165700 @default.
• W3210362920 cites W2254034242 @default.
• W3210362920 cites W2306899626 @default.
• W3210362920 cites W2396165980 @default.
• W3210362920 cites W2408210747 @default.
• W3210362920 cites W2567360788 @default.
• W3210362920 cites W2585998899 @default.
• W3210362920 cites W2631177616 @default.
• W3210362920 cites W2769704927 @default.
• W3210362920 cites W2775905958 @default.
• W3210362920 cites W2803214400 @default.
• W3210362920 cites W2803952373 @default.
• W3210362920 cites W2806185080 @default.
• W3210362920 cites W2811319887 @default.
• W3210362920 cites W2936791073 @default.
• W3210362920 cites W2943112777 @default.
• W3210362920 cites W2946454050 @default.
• W3210362920 cites W2946630278 @default.
• W3210362920 cites W2954871878 @default.
• W3210362920 cites W2957599687 @default.
• W3210362920 cites W2990907516 @default.
• W3210362920 cites W3012542984 @default.
• W3210362920 cites W3034931016 @default.
• W3210362920 cites W3040597694 @default.
• W3210362920 cites W3041685607 @default.
• W3210362920 cites W3082072046 @default.
• W3210362920 cites W3082603359 @default.
• W3210362920 cites W3087951158 @default.
• W3210362920 cites W2072229818 @default.
• W3210362920 doi "https://doi.org/10.1016/b978-0-323-85050-6.00014-1" @default.
• W3210362920 hasPublicationYear "2021" @default.
• W3210362920 type Work @default.
• W3210362920 sameAs 3210362920 @default.
• W3210362920 citedByCount "0" @default.
• W3210362920 crossrefType "book-chapter" @default.
• W3210362920 hasAuthorship W3210362920A5074686635 @default.
• W3210362920 hasConcept C112705442 @default.
• W3210362920 hasConcept C15083742 @default.
• W3210362920 hasConcept C155672457 @default.
• W3210362920 hasConcept C171250308 @default.
• W3210362920 hasConcept C181389837 @default.
• W3210362920 hasConcept C18150654 @default.
• W3210362920 hasConcept C185592680 @default.
• W3210362920 hasConcept C192562407 @default.
• W3210362920 hasConcept C2779820397 @default.
• W3210362920 hasConcept C2780035454 @default.
• W3210362920 hasConcept C69366308 @default.
• W3210362920 hasConcept C71924100 @default.
• W3210362920 hasConcept C98274493 @default.
• W3210362920 hasConceptScore W3210362920C112705442 @default.
• W3210362920 hasConceptScore W3210362920C15083742 @default.
• W3210362920 hasConceptScore W3210362920C155672457 @default.
• W3210362920 hasConceptScore W3210362920C171250308 @default.
• W3210362920 hasConceptScore W3210362920C181389837 @default.
• W3210362920 hasConceptScore W3210362920C18150654 @default.
• W3210362920 hasConceptScore W3210362920C185592680 @default.
• W3210362920 hasConceptScore W3210362920C192562407 @default.
• W3210362920 hasConceptScore W3210362920C2779820397 @default.
• W3210362920 hasConceptScore W3210362920C2780035454 @default.
• W3210362920 hasConceptScore W3210362920C69366308 @default.
• W3210362920 hasConceptScore W3210362920C71924100 @default.
• W3210362920 hasConceptScore W3210362920C98274493 @default.
• W3210362920 hasLocation W32103629201 @default.
• W3210362920 hasOpenAccess W3210362920 @default.
• W3210362920 hasPrimaryLocation W32103629201 @default.
• W3210362920 hasRelatedWork W14373313 @default.
• W3210362920 hasRelatedWork W20820324 @default.
• W3210362920 hasRelatedWork W21320134 @default.
• W3210362920 hasRelatedWork W22471006 @default.
• W3210362920 hasRelatedWork W26544055 @default.
• W3210362920 hasRelatedWork W33263197 @default.
• W3210362920 hasRelatedWork W3379694 @default.
• W3210362920 hasRelatedWork W3385421 @default.
• W3210362920 hasRelatedWork W35076069 @default.
• W3210362920 hasRelatedWork W5997205 @default.
• W3210362920 isParatext "false" @default.
• W3210362920 isRetracted "false" @default.
• W3210362920 magId "3210362920" @default.

• next