FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3210367092> ?p ?o ?g. }

• W3210367092 endingPage "1604" @default.
• W3210367092 startingPage "1604" @default.
• W3210367092 abstract "Butyrates inhibit cell growth in colon cancer cells by inhibiting histone deacetylases. However, chronic exposure to butyrates induces butyrate resistance in colon cancer cells. The mechanism underlying the acquisition of resistance is not yet fully understood. Here, butyrate-resistant (BR) colon cancer cells were developed in HCT116, HT29, and SW480 human colon cancer cells and were confirmed by the increase in the inhibitory concentrations of cell growth by 50% (IC50) compared to their respective parental (PT) cells. Chronic exposure to butyrate induced autophagy via higher expression of Beclin-1 and LC3B-II. The AMP-activated protein kinase (AMPK) was downregulated along with the activation of Akt and mammalian target of rapamycin (mTOR) and decrease in acetyl-CoA carboxylase (ACC) in BR colon cancer cells compared to those in their respective PT cells. Activation of AMPK by AICAR treatment in BR colon cancer cells suppressed cell proliferation by inhibiting Akt and mTOR and activating ACC. Taken together, chronic exposure to butyrate increased butyrate resistance in human colon cancer by inducing protective autophagy through the downregulation of AMPK/ACC and activation of Akt/mTOR signaling. Activation of AMPK restored sensitivity to butyrate by the inhibition of Akt/mTOR, suggesting that AMPK could be a therapeutic target for BR colon cancers." @default.
• W3210367092 created "2021-11-08" @default.
• W3210367092 creator A5048518432 @default.
• W3210367092 creator A5054797701 @default.
• W3210367092 creator A5058128763 @default.
• W3210367092 creator A5085614043 @default.
• W3210367092 date "2021-11-03" @default.
• W3210367092 modified "2023-10-15" @default.
• W3210367092 title "Regulation of Butyrate-Induced Resistance through AMPK Signaling Pathway in Human Colon Cancer Cells" @default.
• W3210367092 cites W111893052 @default.
• W3210367092 cites W1508661542 @default.
• W3210367092 cites W1653274582 @default.
• W3210367092 cites W1919718700 @default.
• W3210367092 cites W1974891767 @default.
• W3210367092 cites W2014379712 @default.
• W3210367092 cites W2022474551 @default.
• W3210367092 cites W2027442494 @default.
• W3210367092 cites W2033830364 @default.
• W3210367092 cites W2044874695 @default.
• W3210367092 cites W2048615215 @default.
• W3210367092 cites W2055811314 @default.
• W3210367092 cites W2061453651 @default.
• W3210367092 cites W2069507800 @default.
• W3210367092 cites W2079351077 @default.
• W3210367092 cites W2082871870 @default.
• W3210367092 cites W2085442981 @default.
• W3210367092 cites W2093555475 @default.
• W3210367092 cites W2112796039 @default.
• W3210367092 cites W2121982452 @default.
• W3210367092 cites W2150787678 @default.
• W3210367092 cites W2160518775 @default.
• W3210367092 cites W2170399575 @default.
• W3210367092 cites W2339110476 @default.
• W3210367092 cites W2404921965 @default.
• W3210367092 cites W2411328842 @default.
• W3210367092 cites W2413775433 @default.
• W3210367092 cites W2526959247 @default.
• W3210367092 cites W2548539834 @default.
• W3210367092 cites W2606111706 @default.
• W3210367092 cites W2778581470 @default.
• W3210367092 cites W2804896220 @default.
• W3210367092 cites W2885366571 @default.
• W3210367092 cites W2886515849 @default.
• W3210367092 cites W2900160284 @default.
• W3210367092 cites W2972499605 @default.
• W3210367092 cites W2974416662 @default.
• W3210367092 cites W2980431614 @default.
• W3210367092 cites W2980631738 @default.
• W3210367092 cites W3036229429 @default.
• W3210367092 doi "https://doi.org/10.3390/biomedicines9111604" @default.
• W3210367092 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8615665" @default.
• W3210367092 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34829834" @default.
• W3210367092 hasPublicationYear "2021" @default.
• W3210367092 type Work @default.
• W3210367092 sameAs 3210367092 @default.
• W3210367092 citedByCount "9" @default.
• W3210367092 countsByYear W32103670922021 @default.
• W3210367092 countsByYear W32103670922022 @default.
• W3210367092 countsByYear W32103670922023 @default.
• W3210367092 crossrefType "journal-article" @default.
• W3210367092 hasAuthorship W3210367092A5048518432 @default.
• W3210367092 hasAuthorship W3210367092A5054797701 @default.
• W3210367092 hasAuthorship W3210367092A5058128763 @default.
• W3210367092 hasAuthorship W3210367092A5085614043 @default.
• W3210367092 hasBestOaLocation W32103670921 @default.
• W3210367092 hasConcept C100544194 @default.
• W3210367092 hasConcept C104317684 @default.
• W3210367092 hasConcept C121608353 @default.
• W3210367092 hasConcept C126322002 @default.
• W3210367092 hasConcept C127561419 @default.
• W3210367092 hasConcept C184235292 @default.
• W3210367092 hasConcept C185592680 @default.
• W3210367092 hasConcept C190283241 @default.
• W3210367092 hasConcept C203522944 @default.
• W3210367092 hasConcept C2776979534 @default.
• W3210367092 hasConcept C2780124434 @default.
• W3210367092 hasConcept C502942594 @default.
• W3210367092 hasConcept C55493867 @default.
• W3210367092 hasConcept C62112901 @default.
• W3210367092 hasConcept C62478195 @default.
• W3210367092 hasConcept C71924100 @default.
• W3210367092 hasConcept C75217442 @default.
• W3210367092 hasConcept C86554907 @default.
• W3210367092 hasConcept C86803240 @default.
• W3210367092 hasConcept C95444343 @default.
• W3210367092 hasConcept C96232424 @default.
• W3210367092 hasConcept C97029542 @default.
• W3210367092 hasConceptScore W3210367092C100544194 @default.
• W3210367092 hasConceptScore W3210367092C104317684 @default.
• W3210367092 hasConceptScore W3210367092C121608353 @default.
• W3210367092 hasConceptScore W3210367092C126322002 @default.
• W3210367092 hasConceptScore W3210367092C127561419 @default.
• W3210367092 hasConceptScore W3210367092C184235292 @default.
• W3210367092 hasConceptScore W3210367092C185592680 @default.
• W3210367092 hasConceptScore W3210367092C190283241 @default.
• W3210367092 hasConceptScore W3210367092C203522944 @default.
• W3210367092 hasConceptScore W3210367092C2776979534 @default.
• W3210367092 hasConceptScore W3210367092C2780124434 @default.

• next