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• W3212364699 abstract "Chromatin profiling in single cells has been extremely challenging and almost exclusively limited to histone proteins. In cases where single-cell methods have shown promise, many require highly specialized equipment or cell type-specific protocols and are relatively low throughput. Here, we combine the advantages of tagmentation, linear amplification, and combinatorial indexing to produce a high-throughput single-cell DNA binding site mapping method that is simple, inexpensive, and capable of multiplexing several independent samples per experiment. Targeted insertion of promoters sequencing (TIP-seq) uses Tn5 fused to proteinA to insert a T7 RNA polymerase promoter adjacent to a chromatin protein of interest. Linear amplification of flanking DNA with T7 polymerase before sequencing library preparation provides ∼10-fold higher unique reads per single cell compared with other methods. We applied TIP-seq to map histone modifications, RNA polymerase II (RNAPII), and transcription factor CTCF binding sites in single human and mouse cells." @default.
• W3212364699 created "2021-11-22" @default.
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• W3212364699 date "2021-11-16" @default.
• W3212364699 modified "2023-10-16" @default.
• W3212364699 title "High-throughput single-cell epigenomic profiling by targeted insertion of promoters (TIP-seq)" @default.
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• W3212364699 doi "https://doi.org/10.1083/jcb.202103078" @default.
• W3212364699 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8600797" @default.
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• W3212364699 hasPublicationYear "2021" @default.
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