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• W347723007 abstract "The fundamental role of a competent host T lymphocyte response for promoting the resolution of acute viral infections is supported by the severe and progressive infections observed in individuals with primary or acquired deficiencies of T cell function (Rosen et al. 1984a, b; Redfield et al. 1987; Englund et al. 1988; Ljungman et al. 1989). The critical immune response is comprised of CD8+ cytotoxic T cells (CTL) and CD4+ helper T cells (Th), which recognize degraded fragments of proteins derived from pathogens and presented in association with class I and class II major histocompatibility complex (MHC) molecules, respectively (Braciale et al. 1987; Yewdell and Bennink 1990). CD8+ CTL function to eradicate viral infection by the direct lysis of infected cells and by the secretion of cytokines such as γ-interferon. The predominant function of CD4+ Th in the host response to infection is the production of cytokines, which in addition to direct antiviral effects facilitate the antiviral activities of macrophages, B cells, and other T cells including CD8+ CTL." @default.
• W347723007 created "2016-06-24" @default.
• W347723007 creator A5030463228 @default.
• W347723007 creator A5087281332 @default.
• W347723007 date "1994-01-01" @default.
• W347723007 modified "2023-10-17" @default.
• W347723007 title "Therapeutic Reconstitution of Human Viral Immunity by Adoptive Transfer of Cytotoxic T Lymphocyte Clones" @default.
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• W347723007 doi "https://doi.org/10.1007/978-3-642-78530-6_2" @default.
• W347723007 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/7924439" @default.
• W347723007 hasPublicationYear "1994" @default.
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