FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4207083374> ?p ?o ?g. }

• W4207083374 abstract "To determine whether concurrent chemotherapy is necessary during locoregional radiotherapy (RT) after palliative chemotherapy (PCT) in patients with de novo metastatic nasopharyngeal carcinoma (mNPC).A total of 746 patients with mNPC from 2000 to 2017 at our hospital were retrospectively reviewed. Among them, 355 patients received PCT followed by RT. Overall survival (OS) and progression-free survival (PFS), including locoregional progression-free survival (LRPFS) and distant progression-free survival (DPFS) were estimated with the Kaplan-Meier method and log-rank test. Cox proportional-hazards models, landmark analyses, propensity score matching, and subgroup analyses were used to address confounding.Of the patients included in our study, 192 received radiotherapy alone after PCT (PCT + RT), and 163 received concurrent chemoradiotherapy after PCT (PCT + CCRT). The prognosis of PCT + CCRT was significantly better than that of PCT + RT (5 year OS, 53.0 vs 36.2%; P = 0.004). After matching, the 5 year OS rates of the two groups were 55.7 and 39.0%, respectively (P = 0.034) and the median DPFS were 29.4 and 18.7 months, respectively (P = 0.052). Multivariate Cox regression analysis indicated that PCT + CCRT was an independent favorable prognostic factor (P = 0.009). In addition, conducting concurrent chemoradiotherapy after 4-6 cycles of PCT or conducting concurrent chemotherapy with single-agent platinum was associated with significant survival benefit in the matched cohort (5 year OS rate, 60.4 or 57.4%, respectively). The survival difference between groups remained significant when evaluating patients who survived for ≥ 1 year (P = 0.028).The optimal treatment strategy of mNPC is the combination of PCT followed by concurrent chemoradiotherapy. More specifically, concurrent chemoradiotherapy with single-agent platinum after 4-6 cycles of PCT is suggested." @default.
• W4207083374 created "2022-01-26" @default.
• W4207083374 creator A5024129197 @default.
• W4207083374 creator A5024945232 @default.
• W4207083374 creator A5026279705 @default.
• W4207083374 creator A5045481241 @default.
• W4207083374 creator A5050517081 @default.
• W4207083374 creator A5063253432 @default.
• W4207083374 creator A5075072377 @default.
• W4207083374 creator A5085629608 @default.
• W4207083374 creator A5090111080 @default.
• W4207083374 date "2022-01-24" @default.
• W4207083374 modified "2023-10-14" @default.
• W4207083374 title "Addition of chemoradiotherapy to palliative chemotherapy in de novo metastatic nasopharyngeal carcinoma: a real-world study" @default.
• W4207083374 cites W1932461622 @default.
• W4207083374 cites W1981239587 @default.
• W4207083374 cites W2008727503 @default.
• W4207083374 cites W2010861323 @default.
• W4207083374 cites W2014401523 @default.
• W4207083374 cites W2019124056 @default.
• W4207083374 cites W2022837929 @default.
• W4207083374 cites W2051262717 @default.
• W4207083374 cites W2052421497 @default.
• W4207083374 cites W2082866722 @default.
• W4207083374 cites W2099743682 @default.
• W4207083374 cites W2116661424 @default.
• W4207083374 cites W2137528712 @default.
• W4207083374 cites W2148900467 @default.
• W4207083374 cites W2167845292 @default.
• W4207083374 cites W2278841906 @default.
• W4207083374 cites W2402497634 @default.
• W4207083374 cites W2605164590 @default.
• W4207083374 cites W2605933992 @default.
• W4207083374 cites W2747272999 @default.
• W4207083374 cites W2768009440 @default.
• W4207083374 cites W2794739281 @default.
• W4207083374 cites W2804086994 @default.
• W4207083374 cites W2890100090 @default.
• W4207083374 cites W2935821643 @default.
• W4207083374 cites W2973205001 @default.
• W4207083374 cites W2999333529 @default.
• W4207083374 cites W3011645032 @default.
• W4207083374 cites W3045194380 @default.
• W4207083374 cites W3080113653 @default.
• W4207083374 cites W4211017340 @default.
• W4207083374 cites W4293384264 @default.
• W4207083374 doi "https://doi.org/10.1186/s12935-022-02464-7" @default.
• W4207083374 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35073926" @default.
• W4207083374 hasPublicationYear "2022" @default.
• W4207083374 type Work @default.
• W4207083374 citedByCount "2" @default.
• W4207083374 countsByYear W42070833742022 @default.
• W4207083374 countsByYear W42070833742023 @default.
• W4207083374 crossrefType "journal-article" @default.
• W4207083374 hasAuthorship W4207083374A5024129197 @default.
• W4207083374 hasAuthorship W4207083374A5024945232 @default.
• W4207083374 hasAuthorship W4207083374A5026279705 @default.
• W4207083374 hasAuthorship W4207083374A5045481241 @default.
• W4207083374 hasAuthorship W4207083374A5050517081 @default.
• W4207083374 hasAuthorship W4207083374A5063253432 @default.
• W4207083374 hasAuthorship W4207083374A5075072377 @default.
• W4207083374 hasAuthorship W4207083374A5085629608 @default.
• W4207083374 hasAuthorship W4207083374A5090111080 @default.
• W4207083374 hasBestOaLocation W42070833741 @default.
• W4207083374 hasConcept C10515644 @default.
• W4207083374 hasConcept C126322002 @default.
• W4207083374 hasConcept C143998085 @default.
• W4207083374 hasConcept C146357865 @default.
• W4207083374 hasConcept C151730666 @default.
• W4207083374 hasConcept C17923572 @default.
• W4207083374 hasConcept C2776694085 @default.
• W4207083374 hasConcept C2778424827 @default.
• W4207083374 hasConcept C2778496288 @default.
• W4207083374 hasConcept C2778997737 @default.
• W4207083374 hasConcept C38180746 @default.
• W4207083374 hasConcept C50382708 @default.
• W4207083374 hasConcept C509974204 @default.
• W4207083374 hasConcept C71924100 @default.
• W4207083374 hasConcept C86803240 @default.
• W4207083374 hasConceptScore W4207083374C10515644 @default.
• W4207083374 hasConceptScore W4207083374C126322002 @default.
• W4207083374 hasConceptScore W4207083374C143998085 @default.
• W4207083374 hasConceptScore W4207083374C146357865 @default.
• W4207083374 hasConceptScore W4207083374C151730666 @default.
• W4207083374 hasConceptScore W4207083374C17923572 @default.
• W4207083374 hasConceptScore W4207083374C2776694085 @default.
• W4207083374 hasConceptScore W4207083374C2778424827 @default.
• W4207083374 hasConceptScore W4207083374C2778496288 @default.
• W4207083374 hasConceptScore W4207083374C2778997737 @default.
• W4207083374 hasConceptScore W4207083374C38180746 @default.
• W4207083374 hasConceptScore W4207083374C50382708 @default.
• W4207083374 hasConceptScore W4207083374C509974204 @default.
• W4207083374 hasConceptScore W4207083374C71924100 @default.
• W4207083374 hasConceptScore W4207083374C86803240 @default.
• W4207083374 hasFunder F4320315254 @default.
• W4207083374 hasFunder F4320321921 @default.
• W4207083374 hasFunder F4320333596 @default.
• W4207083374 hasIssue "1" @default.
• W4207083374 hasLocation W42070833741 @default.
• W4207083374 hasLocation W42070833742 @default.

• next