FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4210363646> ?p ?o ?g. }

• W4210363646 abstract "The status of homologous recombination repair (HRR) gene mutations and their impact on the survival of patients with Chinese epithelial ovarian cancer (EOC) are still unclear. In this study, we retrospectively analyzed the mutations of HRR genes in tumor tissues and evaluated their values for predicting the survival of Chinese EOC patients.A total of 273 primary EOC patients from five different hospitals between 2015 and 2016 were recruited. All patients received staging surgeries or debulking surgeries combined with systemic platinum-based chemotherapy. DNA was extracted from formalin-fixed, paraffin-embedded sections and analyzed for mutations using a 21-gene panel (including 13 well-known HRR genes) by next-generation sequencing.High-grade serous carcinoma (HGSOC) accounted for 76.2% of the cohort. A total of 34.1% (93/273) cases had 99 deleterious mutations in 9 HRR genes, namely, BRCA1 (56/273, 20.5%), BRCA2 (20/273, 7.3%), ATM (5/273, 1.8%), RAD51C (5/273, 1.8%), RAD51D (5/273, 1.8%), BRIP1 (2/273, 1.8%), CHEK2 (2/273, 0.7%), FANCI (2/273, 0.7%), and RAD54L (1/273, 0.4%). There is a strong mutual exclusion between HRR genes. The mutation landscape revealed several unappreciated deleterious variants in BRCA1/2 and other HRR genes reported previously. Estimated according to the mutation allele frequency, about 4.8% of the patients had potential somatic HRR gene mutations, which might be underestimated. Moreover, HRR mutations mainly exist in HGSOC (83/208, 39.9%), clear cell (2/30, 6.7%), and endometroid subtypes (8/20, 40%), but not seen in other rare subtypes. BRCA1 mutations tend to be present in younger patients with family history or multiple primary foci. Patients with BRCA1/2 mutations tend to have a longer progression-free survival and overall survival, while other HRR mutation carriers tend to have a shorter progression-free survival, but no significant difference in overall survival.This study revealed the distribution of HRR gene mutations in Chinese EOC tissues. BRCA1/2 account for the majority of HRR gene mutations and predict long prognosis in HGSOC. Non-BRCA HRR mutations also account for a very important proportion and might be associated with poor prognosis in HGSOC. It is suggested that HRR gene mutations need to be detected in EOC tissues and germline status be further clarified in clinical algorithm for potential targeted therapy, genetic screening, and prognosis prediction." @default.
• W4210363646 created "2022-02-08" @default.
• W4210363646 creator A5010219739 @default.
• W4210363646 creator A5015088500 @default.
• W4210363646 creator A5017941291 @default.
• W4210363646 creator A5026148142 @default.
• W4210363646 creator A5027030582 @default.
• W4210363646 creator A5035282947 @default.
• W4210363646 creator A5054317843 @default.
• W4210363646 creator A5060264631 @default.
• W4210363646 creator A5060425100 @default.
• W4210363646 creator A5063900505 @default.
• W4210363646 creator A5067510740 @default.
• W4210363646 creator A5069151097 @default.
• W4210363646 creator A5073699504 @default.
• W4210363646 creator A5074747392 @default.
• W4210363646 date "2022-02-03" @default.
• W4210363646 modified "2023-10-16" @default.
• W4210363646 title "Mutation Landscape of Homologous Recombination Repair Genes in Epithelial Ovarian Cancer in China and Its Relationship With Clinicopathlological Characteristics" @default.
• W4210363646 cites W1919257374 @default.
• W4210363646 cites W2051978340 @default.
• W4210363646 cites W2103441770 @default.
• W4210363646 cites W2106157865 @default.
• W4210363646 cites W2112657305 @default.
• W4210363646 cites W2117964602 @default.
• W4210363646 cites W2123696077 @default.
• W4210363646 cites W2135195813 @default.
• W4210363646 cites W2142658272 @default.
• W4210363646 cites W2145964812 @default.
• W4210363646 cites W2155943701 @default.
• W4210363646 cites W2169983032 @default.
• W4210363646 cites W2224210111 @default.
• W4210363646 cites W2272984102 @default.
• W4210363646 cites W2310932393 @default.
• W4210363646 cites W2528228811 @default.
• W4210363646 cites W2586740146 @default.
• W4210363646 cites W2594404528 @default.
• W4210363646 cites W2595690372 @default.
• W4210363646 cites W2734285929 @default.
• W4210363646 cites W2754327139 @default.
• W4210363646 cites W2772338061 @default.
• W4210363646 cites W2786268518 @default.
• W4210363646 cites W2807649309 @default.
• W4210363646 cites W2885135929 @default.
• W4210363646 cites W2896250649 @default.
• W4210363646 cites W2896626889 @default.
• W4210363646 cites W2943415606 @default.
• W4210363646 cites W2984589472 @default.
• W4210363646 cites W2990717414 @default.
• W4210363646 cites W2999417355 @default.
• W4210363646 cites W3010030389 @default.
• W4210363646 cites W3010654133 @default.
• W4210363646 cites W3011100955 @default.
• W4210363646 cites W3013350468 @default.
• W4210363646 cites W3020771563 @default.
• W4210363646 cites W3047408082 @default.
• W4210363646 cites W3081569548 @default.
• W4210363646 cites W3119672763 @default.
• W4210363646 cites W3135403286 @default.
• W4210363646 cites W3199207936 @default.
• W4210363646 doi "https://doi.org/10.3389/fonc.2022.709645" @default.
• W4210363646 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35186721" @default.
• W4210363646 hasPublicationYear "2022" @default.
• W4210363646 type Work @default.
• W4210363646 citedByCount "3" @default.
• W4210363646 countsByYear W42103636462022 @default.
• W4210363646 crossrefType "journal-article" @default.
• W4210363646 hasAuthorship W4210363646A5010219739 @default.
• W4210363646 hasAuthorship W4210363646A5015088500 @default.
• W4210363646 hasAuthorship W4210363646A5017941291 @default.
• W4210363646 hasAuthorship W4210363646A5026148142 @default.
• W4210363646 hasAuthorship W4210363646A5027030582 @default.
• W4210363646 hasAuthorship W4210363646A5035282947 @default.
• W4210363646 hasAuthorship W4210363646A5054317843 @default.
• W4210363646 hasAuthorship W4210363646A5060264631 @default.
• W4210363646 hasAuthorship W4210363646A5060425100 @default.
• W4210363646 hasAuthorship W4210363646A5063900505 @default.
• W4210363646 hasAuthorship W4210363646A5067510740 @default.
• W4210363646 hasAuthorship W4210363646A5069151097 @default.
• W4210363646 hasAuthorship W4210363646A5073699504 @default.
• W4210363646 hasAuthorship W4210363646A5074747392 @default.
• W4210363646 hasBestOaLocation W42103636461 @default.
• W4210363646 hasConcept C102744134 @default.
• W4210363646 hasConcept C104317684 @default.
• W4210363646 hasConcept C121608353 @default.
• W4210363646 hasConcept C126322002 @default.
• W4210363646 hasConcept C134935766 @default.
• W4210363646 hasConcept C13514818 @default.
• W4210363646 hasConcept C143998085 @default.
• W4210363646 hasConcept C150173356 @default.
• W4210363646 hasConcept C2776071976 @default.
• W4210363646 hasConcept C2777632260 @default.
• W4210363646 hasConcept C2780427987 @default.
• W4210363646 hasConcept C2781100745 @default.
• W4210363646 hasConcept C501734568 @default.
• W4210363646 hasConcept C502942594 @default.
• W4210363646 hasConcept C54355233 @default.
• W4210363646 hasConcept C71924100 @default.
• W4210363646 hasConcept C86803240 @default.
• W4210363646 hasConceptScore W4210363646C102744134 @default.

• next