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- W4212826067 endingPage "100223" @default.
- W4212826067 startingPage "100223" @default.
- W4212826067 abstract "Inflammatory arthritis is a major cause of disability in the elderly. This condition causes joint pain, loss of function, and deterioration of quality of life, mainly due to osteoarthritis (OA) and rheumatoid arthritis (RA). Currently, available treatment options for inflammatory arthritis include anti-inflammatory medications administered via oral, topical, or intra-articular routes, surgery, and physical rehabilitation. Novel alternative approaches to managing inflammatory arthritis, so far, remain the grand challenge owing to catastrophic financial burden and insignificant therapeutic benefit. In the view of non-targeted systemic cytotoxicity and limited bioavailability of drug therapies, a major concern is to establish stimuli-responsive drug delivery systems using nanomaterials with on-off switching potential for biomedical applications. This review summarizes the advanced applications of triggerable nanomaterials dependent on various internal stimuli (including reduction-oxidation (redox), pH, and enzymes) and external stimuli (including temperature, ultrasound (US), magnetic, photo, voltage, and mechanical friction). The review also explores the progress and challenges with the use of stimuli-responsive nanomaterials to manage inflammatory arthritis based on pathological changes, including cartilage degeneration, synovitis, and subchondral bone destruction. Exposure to appropriate stimuli induced by such histopathological alterations can trigger the release of therapeutic medications, imperative in the joint-targeted treatment of inflammatory arthritis." @default.
- W4212826067 created "2022-02-24" @default.
- W4212826067 creator A5005913827 @default.
- W4212826067 creator A5021950163 @default.
- W4212826067 creator A5036897639 @default.
- W4212826067 creator A5044825462 @default.
- W4212826067 creator A5062426880 @default.
- W4212826067 creator A5083720055 @default.
- W4212826067 date "2022-03-01" @default.
- W4212826067 modified "2023-10-18" @default.
- W4212826067 title "Advanced application of stimuli-responsive drug delivery system for inflammatory arthritis treatment" @default.
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