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- W4221003477 abstract "The development of new drugs is continuous in the world; currently, saving resources (both economic ones and time) and preventing secondary effects have become a necessity for drug developers. Trichomoniasis is the most common nonviral sexually transmitted infection affecting more than 270 million people around the world. In our research group, we focussed on developing a selective and more effective drug against Trichomonas vaginalis, and we previously reported on a compound, called A4, which had a trichomonacidal effect. Later, we determined another compound, called D4, which also had a trichomonacidal effect together with favorable toxicity results. Both A4 and D4 are directed at the enzyme triosephosphate isomerase. Thus, we made combinations between the two compounds, in which we determined a synergistic effect against T. vaginalis, determining the IC50 and the toxicity of the best relationship to obtain the trichomonacidal effect. With these results, we can propose a combination of compounds that represents a promising alternative for the development of a new therapeutic strategy against trichomoniasis." @default.
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- W4221003477 date "2022-03-25" @default.
- W4221003477 modified "2023-10-18" @default.
- W4221003477 title "Synergistic effect of compounds directed to triosephosphate isomerase, a combination to develop drug against trichomoniasis" @default.
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- W4221003477 doi "https://doi.org/10.1002/ardp.202200046" @default.
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