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• W4221036282 abstract "Significance Studies in multiple experimental systems have demonstrated that an increase in proteolytic capacity of post-mitotic cells improves cellular resistance to a variety of stressors, delays cellular aging and senescence. Therefore, approaches to increase the ability of cells to degrade misfolded proteins could potentially be applied to the treatment of a broad spectrum of human disorders. An example would be retinal degenerations, which cause irreversible loss of vision and are linked to impaired protein degradation. This study suggests that chronic activation of the mammalian target of rapamycin complex 1 (mTORC1) pathway in degenerating photoreceptor neurons could stimulate the degradation of ubiquitinated proteins and enhance proteasomal activity through phosphorylation." @default.
• W4221036282 created "2022-04-03" @default.
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• W4221036282 date "2022-03-11" @default.
• W4221036282 modified "2023-10-14" @default.
• W4221036282 title "Tsc2 knockout counteracts ubiquitin-proteasome system insufficiency and delays photoreceptor loss in retinitis pigmentosa" @default.
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• W4221036282 doi "https://doi.org/10.1073/pnas.2118479119" @default.
• W4221036282 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35275792" @default.
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