FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4225522994> ?p ?o ?g. }

• W4225522994 abstract "CsrA is a global regulator widespread in bacteria and known to be involved in different physiological processes, including pathogenicity. Deletion of csrA of Acinetobacter baumannii strain ATCC 19606 resulted in a mutant that was unable to utilize a broad range of carbon and energy sources, including amino acids. This defect in amino acid metabolism was most likely responsible for the growth inhibition of the ΔcsrA mutant in human urine, where amino acids are the most abundant carbon source for A. baumannii. Recent studies revealed that deletion of csrA in the A. baumannii strains AB09-003 and ATCC 17961 resulted in an increase in hyperosmotic stress resistance. However, the molecular basis for this observation remained unknown. This study aimed to investigate the role of CsrA in compatible solute synthesis. We observed striking differences in the ability of different A. baumannii strains to cope with hyperosmotic stress. Strains AB09-003 and ATCC 17961 were strongly impaired in hyperosmotic stress resistance in comparison to strain ATCC 19606. These differences were abolished by deletion of csrA and are in line with the ability to synthesize compatible solutes. In the salt-sensitive strains AB09-003 and ATCC 17961, compatible solute synthesis was repressed by CsrA. This impairment is mediated via CsrA and could be overcome by deletion of csrA from the genome. IMPORTANCE The opportunistic human pathogen Acinetobacter baumannii has become one of the leading causes of nosocomial infections around the world due to the increasing prevalence of multidrug-resistant strains and their optimal adaptation to clinical environments and the human host. Recently, it was found that CsrA, a global mRNA binding posttranscriptional regulator, plays a role in osmotic stress adaptation, virulence, and growth on amino acids of A. baumannii AB09-003 and ATCC 17961. Here, we report that this is also the case for A. baumannii ATCC 19606. However, we observed significant differences in the ΔcsrA mutants with respect to osmostress resistance, such as the AB09-003 and 17961 mutants being enhanced in osmostress resistance whereas the ATCC 19606 mutant was not. This suggests that the role of CsrA in osmotic stress adaptation is strain specific. Furthermore, we provide clear evidence that CsrA is essential for growth in human urine and at high temperatures." @default.
• W4225522994 created "2022-05-05" @default.
• W4225522994 creator A5019425900 @default.
• W4225522994 creator A5031312594 @default.
• W4225522994 creator A5061802621 @default.
• W4225522994 creator A5082344741 @default.
• W4225522994 date "2021-12-22" @default.
• W4225522994 modified "2023-10-16" @default.
• W4225522994 title "CsrA Coordinates Compatible Solute Synthesis in Acinetobacter baumannii and Facilitates Growth in Human Urine" @default.
• W4225522994 cites W1509557781 @default.
• W4225522994 cites W1530054305 @default.
• W4225522994 cites W1573786785 @default.
• W4225522994 cites W1943327251 @default.
• W4225522994 cites W2006881751 @default.
• W4225522994 cites W2007489473 @default.
• W4225522994 cites W2025341712 @default.
• W4225522994 cites W2035522114 @default.
• W4225522994 cites W2035789401 @default.
• W4225522994 cites W2038042681 @default.
• W4225522994 cites W2042065648 @default.
• W4225522994 cites W2042268643 @default.
• W4225522994 cites W2075918297 @default.
• W4225522994 cites W2080758881 @default.
• W4225522994 cites W2086076421 @default.
• W4225522994 cites W2089219693 @default.
• W4225522994 cites W2091375799 @default.
• W4225522994 cites W2102877662 @default.
• W4225522994 cites W2105479160 @default.
• W4225522994 cites W2106641250 @default.
• W4225522994 cites W2107869090 @default.
• W4225522994 cites W2113513236 @default.
• W4225522994 cites W2117689688 @default.
• W4225522994 cites W2127028391 @default.
• W4225522994 cites W2142105619 @default.
• W4225522994 cites W2143897202 @default.
• W4225522994 cites W2147761472 @default.
• W4225522994 cites W2148506275 @default.
• W4225522994 cites W2148749381 @default.
• W4225522994 cites W2156075029 @default.
• W4225522994 cites W2159435953 @default.
• W4225522994 cites W2164989938 @default.
• W4225522994 cites W2168168071 @default.
• W4225522994 cites W2171983532 @default.
• W4225522994 cites W2172312875 @default.
• W4225522994 cites W2183596983 @default.
• W4225522994 cites W2197834804 @default.
• W4225522994 cites W2262916401 @default.
• W4225522994 cites W2283293285 @default.
• W4225522994 cites W2288832928 @default.
• W4225522994 cites W2766491151 @default.
• W4225522994 cites W2767975066 @default.
• W4225522994 cites W2790982589 @default.
• W4225522994 cites W2800264815 @default.
• W4225522994 cites W2896486358 @default.
• W4225522994 cites W2897939399 @default.
• W4225522994 cites W2910616868 @default.
• W4225522994 cites W2914763394 @default.
• W4225522994 cites W2916422401 @default.
• W4225522994 cites W2950862496 @default.
• W4225522994 cites W2951619391 @default.
• W4225522994 cites W2962201066 @default.
• W4225522994 cites W3007015863 @default.
• W4225522994 cites W3013077646 @default.
• W4225522994 cites W3020256153 @default.
• W4225522994 cites W3025657904 @default.
• W4225522994 cites W3040437633 @default.
• W4225522994 cites W3088052812 @default.
• W4225522994 cites W3095723103 @default.
• W4225522994 cites W3172731628 @default.
• W4225522994 doi "https://doi.org/10.1128/spectrum.01296-21" @default.
• W4225522994 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34730379" @default.
• W4225522994 hasPublicationYear "2021" @default.
• W4225522994 type Work @default.
• W4225522994 citedByCount "7" @default.
• W4225522994 countsByYear W42255229942022 @default.
• W4225522994 countsByYear W42255229942023 @default.
• W4225522994 crossrefType "journal-article" @default.
• W4225522994 hasAuthorship W4225522994A5019425900 @default.
• W4225522994 hasAuthorship W4225522994A5031312594 @default.
• W4225522994 hasAuthorship W4225522994A5061802621 @default.
• W4225522994 hasAuthorship W4225522994A5082344741 @default.
• W4225522994 hasBestOaLocation W42255229943 @default.
• W4225522994 hasConcept C104317684 @default.
• W4225522994 hasConcept C105702510 @default.
• W4225522994 hasConcept C127716648 @default.
• W4225522994 hasConcept C143065580 @default.
• W4225522994 hasConcept C2776315533 @default.
• W4225522994 hasConcept C2777637488 @default.
• W4225522994 hasConcept C2778022156 @default.
• W4225522994 hasConcept C2778523567 @default.
• W4225522994 hasConcept C523546767 @default.
• W4225522994 hasConcept C54355233 @default.
• W4225522994 hasConcept C70883133 @default.
• W4225522994 hasConcept C86803240 @default.
• W4225522994 hasConcept C89423630 @default.
• W4225522994 hasConceptScore W4225522994C104317684 @default.
• W4225522994 hasConceptScore W4225522994C105702510 @default.
• W4225522994 hasConceptScore W4225522994C127716648 @default.
• W4225522994 hasConceptScore W4225522994C143065580 @default.
• W4225522994 hasConceptScore W4225522994C2776315533 @default.

• next