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- W4225549794 abstract "Abstract Macrocycles with a functionalized interior, which is a general cavity feature of bioreceptors, are relatively hard to synthesize. Here we report a modular strategy to customize diverse endo ‐binding sites in the macrocycle cavity. Only two steps are needed. First, one V‐shaped functional module bearing an embedded binding site and two 2,5‐dimethoxyphenyls as reaction modules are connected. Then the condensation of the resulting monomer and paraformaldehyde directly produces the designed macrocycle. V‐shaped monomers are deliberately used to guarantee the binding sites equatorially directing inward into the cavity and 2,5‐dimethoxyphenyls standing axially as macrocycle sidewalls. More than a dozen endo ‐functionalized macrocyclic receptors have been constructed. Host–guest complexation studies show that macrocycle BP1‐decorated interior OH moieties can strongly encapsulate neutral azacycles by forming inner hydrogen bonds, giving a high association constant of 4.59×10 4 M −1 in non‐polar media." @default.
- W4225549794 created "2022-05-05" @default.
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- W4225549794 date "2022-05-03" @default.
- W4225549794 modified "2023-10-17" @default.
- W4225549794 title "Modular Introduction of Endo‐Binding Sites in Macrocycle Cavity towards Selective Recognition of Neutral Azacycles" @default.
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- W4225549794 doi "https://doi.org/10.1002/ange.202203016" @default.
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