Matches in SemOpenAlex for { <https://semopenalex.org/work/W4249145280> ?p ?o ?g. }
- W4249145280 endingPage "841" @default.
- W4249145280 startingPage "829" @default.
- W4249145280 abstract "The control of human fertility would be revolutionised by the development of a safe, effective, long-acting contraceptive vaccine. The pursuit of this objective has involved the selection of appropriate targets within the reproductive process that are amenable to interference with antibodies. To date, three major targets have been researched. The zona pellucida (ZP) plays key roles in folliculogenesis, fertilisation and early development, and is comprised of powerful cell-specific antigens. The induction of infertility requires high ZP antibody titres that are difficult to maintain without inducing ovarian pathology characterised by a premature loss of primordial follicles. As a premature menopause would be a high price to pay for long-term contraception, this approach to a vaccine cannot progress until the cause of the ovarian pathology has been resolved. Sperm surface antigens represent another promising approach to contraceptive vaccine development. While there is some clinical data to support the likely efficacy of this strategy, none of the gamete-specific molecules characterised to date have fulfilled this promise. Anti-human chorionic gonadotropin (hCG) vaccines terminate pregnancy by preventing the maternal recognition of pregnancy. This vaccine has reached the stage of clinical trials, and preliminary indications are that the approach is safe and potentially effective. However, reliability may be an issue, given the observed inter-individual variability in antibody generation. The future of contraceptive vaccine development will clearly involve a continuation of the intense search for suitable targets and the development of improved immunisation procedures that exploit the latest innovations in vaccine technology." @default.
- W4249145280 created "2022-05-12" @default.
- W4249145280 creator A5015995065 @default.
- W4249145280 creator A5059617337 @default.
- W4249145280 creator A5088651676 @default.
- W4249145280 date "2003-08-01" @default.
- W4249145280 modified "2023-09-27" @default.
- W4249145280 title "Contraceptive vaccines" @default.
- W4249145280 cites W1481794779 @default.
- W4249145280 cites W1486895457 @default.
- W4249145280 cites W1579042999 @default.
- W4249145280 cites W1608119507 @default.
- W4249145280 cites W1794113482 @default.
- W4249145280 cites W1817446171 @default.
- W4249145280 cites W1924379900 @default.
- W4249145280 cites W1968574939 @default.
- W4249145280 cites W1970333486 @default.
- W4249145280 cites W1972176304 @default.
- W4249145280 cites W1977297266 @default.
- W4249145280 cites W1979166051 @default.
- W4249145280 cites W1979200913 @default.
- W4249145280 cites W1982667635 @default.
- W4249145280 cites W1983431264 @default.
- W4249145280 cites W1983995459 @default.
- W4249145280 cites W1988070981 @default.
- W4249145280 cites W1993808853 @default.
- W4249145280 cites W1995246337 @default.
- W4249145280 cites W1995277973 @default.
- W4249145280 cites W2000639720 @default.
- W4249145280 cites W2002167432 @default.
- W4249145280 cites W2004703130 @default.
- W4249145280 cites W2004770115 @default.
- W4249145280 cites W2005668319 @default.
- W4249145280 cites W2007248043 @default.
- W4249145280 cites W2013888031 @default.
- W4249145280 cites W2016379965 @default.
- W4249145280 cites W2018679102 @default.
- W4249145280 cites W2021121382 @default.
- W4249145280 cites W2023300774 @default.
- W4249145280 cites W2027318237 @default.
- W4249145280 cites W2029171490 @default.
- W4249145280 cites W2032162664 @default.
- W4249145280 cites W2032451916 @default.
- W4249145280 cites W2032803320 @default.
- W4249145280 cites W2045910789 @default.
- W4249145280 cites W2047413994 @default.
- W4249145280 cites W2048659272 @default.
- W4249145280 cites W2049303151 @default.
- W4249145280 cites W2054798744 @default.
- W4249145280 cites W2061238369 @default.
- W4249145280 cites W2061648581 @default.
- W4249145280 cites W2063475243 @default.
- W4249145280 cites W2068824219 @default.
- W4249145280 cites W2075384337 @default.
- W4249145280 cites W2077700036 @default.
- W4249145280 cites W2078976297 @default.
- W4249145280 cites W2078991587 @default.
- W4249145280 cites W2084630434 @default.
- W4249145280 cites W2088149980 @default.
- W4249145280 cites W2089024888 @default.
- W4249145280 cites W2089826191 @default.
- W4249145280 cites W2092656885 @default.
- W4249145280 cites W2103624642 @default.
- W4249145280 cites W2104523027 @default.
- W4249145280 cites W2104892940 @default.
- W4249145280 cites W2105667065 @default.
- W4249145280 cites W2108483476 @default.
- W4249145280 cites W2110454473 @default.
- W4249145280 cites W2110952680 @default.
- W4249145280 cites W2113042840 @default.
- W4249145280 cites W2114969886 @default.
- W4249145280 cites W2127152669 @default.
- W4249145280 cites W2129322668 @default.
- W4249145280 cites W2129841410 @default.
- W4249145280 cites W2132658004 @default.
- W4249145280 cites W2137834724 @default.
- W4249145280 cites W2138080570 @default.
- W4249145280 cites W2139690619 @default.
- W4249145280 cites W2146816283 @default.
- W4249145280 cites W2148948968 @default.
- W4249145280 cites W2152524896 @default.
- W4249145280 cites W2163032044 @default.
- W4249145280 cites W2164835119 @default.
- W4249145280 cites W2167896155 @default.
- W4249145280 cites W2168301890 @default.
- W4249145280 cites W2187543765 @default.
- W4249145280 cites W2286401262 @default.
- W4249145280 cites W2410765685 @default.
- W4249145280 cites W4235606329 @default.
- W4249145280 cites W4293039848 @default.
- W4249145280 doi "https://doi.org/10.1517/14712598.3.5.829" @default.
- W4249145280 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/12880382" @default.
- W4249145280 hasPublicationYear "2003" @default.
- W4249145280 type Work @default.
- W4249145280 citedByCount "13" @default.
- W4249145280 countsByYear W42491452802014 @default.
- W4249145280 countsByYear W42491452802017 @default.
- W4249145280 countsByYear W42491452802022 @default.