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• W4253365902 abstract "<sec> <title>BACKGROUND</title> Bone and muscle are closely linked anatomically, biochemically, and metabolically. Acute exercise affects both bone and muscle, implying a crosstalk between the two systems. However, how these two systems communicate is still largely unknown. We will explore the role of undercarboxylated osteocalcin (ucOC) in this crosstalk. ucOC is involved in glucose metabolism and has a potential role in muscle maintenance and metabolism. </sec> <sec> <title>OBJECTIVE</title> The proposed trial will determine if circulating ucOC levels in older adults at baseline and following acute exercise are associated with parameters of muscle function and if the ucOC response to exercise varies between older adults with low muscle quality and those with normal or high muscle quality. </sec> <sec> <title>METHODS</title> A total of 54 men and women aged 60 years or older with no history of diabetes and warfarin and vitamin K use will be recruited. Screening tests will be performed, including those for functional, anthropometric, and clinical presentation. On the basis of muscle quality, a combined equation of lean mass (leg appendicular skeletal muscle mass in kg) and strength (leg press; one-repetition maximum), participants will be stratified into a high or low muscle function group and randomized into the controlled crossover acute intervention. Three visits will be performed approximately 7 days apart, and acute aerobic exercise, acute resistance exercise, and a control session (rest) will be completed in any order. Our primary outcome for this study is the effect of acute exercise on ucOC in older adults with low muscle function and those with high muscle function. </sec> <sec> <title>RESULTS</title> The trial is active and ongoing. Recruitment began in February 2018, and 38 participants have completed the study as of May 26, 2019. </sec> <sec> <title>CONCLUSIONS</title> This study will provide novel insights into bone and muscle crosstalk in older adults, potentially identifying new clinical biomarkers and mechanistic targets for drug treatments for sarcopenia and other related musculoskeletal conditions. </sec> <sec> <title>CLINICALTRIAL</title> Australia New Zealand Clinical Trials Registry ACTRN12618001756213; https://www.anzctr.org.au/Trial/Registration/TrialReview.aspx?id=375925. </sec> <sec> <title>INTERNATIONAL REGISTERED REPORT</title> DERR1-10.2196/18777 </sec>" @default.
• W4253365902 created "2022-05-12" @default.
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• W4253365902 date "2020-03-18" @default.
• W4253365902 modified "2023-09-23" @default.
• W4253365902 title "Uncovering the Bone-Muscle Interaction and Its Implications for the Health and Function of Older Adults (the Wellderly Project): Protocol for a Randomized Controlled Crossover Trial (Preprint)" @default.
• W4253365902 cites W1497300323 @default.
• W4253365902 cites W1524620793 @default.
• W4253365902 cites W1598812626 @default.
• W4253365902 cites W1802503633 @default.
• W4253365902 cites W1965180760 @default.
• W4253365902 cites W1980740451 @default.
• W4253365902 cites W1981833135 @default.
• W4253365902 cites W1985381832 @default.
• W4253365902 cites W1994322943 @default.
• W4253365902 cites W1996752963 @default.
• W4253365902 cites W1997177472 @default.
• W4253365902 cites W2000156550 @default.
• W4253365902 cites W2000445173 @default.
• W4253365902 cites W2000779652 @default.
• W4253365902 cites W2001482745 @default.
• W4253365902 cites W2007154245 @default.
• W4253365902 cites W2008352062 @default.
• W4253365902 cites W2012248550 @default.
• W4253365902 cites W2012502318 @default.
• W4253365902 cites W2021903494 @default.
• W4253365902 cites W2027934034 @default.
• W4253365902 cites W2028108805 @default.
• W4253365902 cites W2028840009 @default.
• W4253365902 cites W2031777038 @default.
• W4253365902 cites W2035181707 @default.
• W4253365902 cites W2042600123 @default.
• W4253365902 cites W2043380758 @default.
• W4253365902 cites W2047562911 @default.
• W4253365902 cites W2048012957 @default.
• W4253365902 cites W2050743691 @default.
• W4253365902 cites W2052673490 @default.
• W4253365902 cites W2054594032 @default.
• W4253365902 cites W2056125499 @default.
• W4253365902 cites W2057015614 @default.
• W4253365902 cites W2062671933 @default.
• W4253365902 cites W2066375889 @default.
• W4253365902 cites W2066849968 @default.
• W4253365902 cites W2067741037 @default.
• W4253365902 cites W2085191949 @default.
• W4253365902 cites W2085493665 @default.
• W4253365902 cites W2087574339 @default.
• W4253365902 cites W2090448309 @default.
• W4253365902 cites W2092068607 @default.
• W4253365902 cites W2096820322 @default.
• W4253365902 cites W2100765156 @default.
• W4253365902 cites W2101192709 @default.
• W4253365902 cites W2101577087 @default.
• W4253365902 cites W2103287170 @default.
• W4253365902 cites W2108063837 @default.
• W4253365902 cites W2120046553 @default.
• W4253365902 cites W2121656227 @default.
• W4253365902 cites W2122613011 @default.
• W4253365902 cites W2123306045 @default.
• W4253365902 cites W2123990725 @default.
• W4253365902 cites W2124423719 @default.
• W4253365902 cites W2129063712 @default.
• W4253365902 cites W2129312503 @default.
• W4253365902 cites W2130642386 @default.
• W4253365902 cites W2133576538 @default.
• W4253365902 cites W2135046649 @default.
• W4253365902 cites W2136329682 @default.
• W4253365902 cites W2144142427 @default.
• W4253365902 cites W2144651037 @default.
• W4253365902 cites W2147392425 @default.
• W4253365902 cites W2149112674 @default.
• W4253365902 cites W2154496298 @default.
• W4253365902 cites W2154692607 @default.
• W4253365902 cites W2156791190 @default.
• W4253365902 cites W2157464989 @default.
• W4253365902 cites W2158833450 @default.
• W4253365902 cites W2170302543 @default.
• W4253365902 cites W2171071516 @default.
• W4253365902 cites W2171329429 @default.
• W4253365902 cites W2285962301 @default.
• W4253365902 cites W2300784889 @default.
• W4253365902 cites W2424118832 @default.
• W4253365902 cites W2479847107 @default.
• W4253365902 cites W2555005101 @default.
• W4253365902 cites W2559649367 @default.
• W4253365902 cites W2612238022 @default.
• W4253365902 cites W2622007407 @default.
• W4253365902 cites W2729907866 @default.
• W4253365902 cites W2738084036 @default.
• W4253365902 cites W2773181055 @default.

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