Matches in SemOpenAlex for { <https://semopenalex.org/work/W4280492099> ?p ?o ?g. }
- W4280492099 endingPage "113087" @default.
- W4280492099 startingPage "113087" @default.
- W4280492099 abstract "Long non-coding RNAs (lncRNAs), a class of RNA transcripts longer than 200 nucleotides, do not encode proteins; however, they encode small peptides and micropeptides that act as bioactive peptides with notable effects in regulating the progression of malignant tumors, such as lung and colorectal cancers, and affecting patient prognosis. lncRNAs are important intracellular regulators, particularly in tumorigenesis and tumor progression. Long intergenic non-protein coding RNA958 (LINC00958), which has received increasing attention in recent years, is highly expressed in various malignancies, including head and neck squamous cell carcinoma (HNSC), non-small-cell lung cancer (NSCLC), gastric cancer, hepatocellular carcinoma (HCC), colorectal cancer, bladder cancer, and breast cancer. Here, we reviewed the recent studies on LINC00958 as well as its closely related clinical features and functional regulation in cancers. We systematically expounded the molecular mechanisms underlying the biological functions of LINC00958 in inhibiting cell apoptosis and enhancing the chemoradiotherapy resistance of tumor cells. The upregulation of LINC00958 enhances the resistance of tumor cells to radiotherapy and chemotherapy and induces lymphangiogenesis. Moreover, it is involved in tumor glycolytic metabolism, which plays a crucial role in facilitating the proliferation, invasion, and migration of tumor cells. Additionally, analysis of various studies revealed that LINC00958 acts as an endogenous competitive RNA (ceRNA) and regulates the malignant behavior of tumor cells through the miRNA-mRNA axis. Collectively, the use of LINC00958 as a novel biomarker and therapeutic target for the clinical diagnosis and treatment of different cancers has bright prospects in the future." @default.
- W4280492099 created "2022-05-22" @default.
- W4280492099 creator A5019698232 @default.
- W4280492099 creator A5055301043 @default.
- W4280492099 creator A5074753445 @default.
- W4280492099 creator A5085203241 @default.
- W4280492099 date "2022-07-01" @default.
- W4280492099 modified "2023-09-26" @default.
- W4280492099 title "LINC00958: A promising long non-coding RNA related to cancer" @default.
- W4280492099 cites W1986989569 @default.
- W4280492099 cites W2008757142 @default.
- W4280492099 cites W2068205741 @default.
- W4280492099 cites W2071271349 @default.
- W4280492099 cites W2100173894 @default.
- W4280492099 cites W2125548623 @default.
- W4280492099 cites W2129824771 @default.
- W4280492099 cites W2146629016 @default.
- W4280492099 cites W2149163652 @default.
- W4280492099 cites W2158025958 @default.
- W4280492099 cites W2166616170 @default.
- W4280492099 cites W2216283224 @default.
- W4280492099 cites W2221837786 @default.
- W4280492099 cites W2274595380 @default.
- W4280492099 cites W2333367339 @default.
- W4280492099 cites W2335029242 @default.
- W4280492099 cites W2603736483 @default.
- W4280492099 cites W2611846352 @default.
- W4280492099 cites W2752862273 @default.
- W4280492099 cites W2765576980 @default.
- W4280492099 cites W2784977872 @default.
- W4280492099 cites W2786987313 @default.
- W4280492099 cites W2793768204 @default.
- W4280492099 cites W2829377719 @default.
- W4280492099 cites W2883632755 @default.
- W4280492099 cites W2902688662 @default.
- W4280492099 cites W2910202498 @default.
- W4280492099 cites W2910789146 @default.
- W4280492099 cites W2915777758 @default.
- W4280492099 cites W2919004555 @default.
- W4280492099 cites W2920353286 @default.
- W4280492099 cites W2923315793 @default.
- W4280492099 cites W2931898983 @default.
- W4280492099 cites W2937766145 @default.
- W4280492099 cites W2941285913 @default.
- W4280492099 cites W2948423997 @default.
- W4280492099 cites W2951206054 @default.
- W4280492099 cites W2951715207 @default.
- W4280492099 cites W2963434743 @default.
- W4280492099 cites W2964318180 @default.
- W4280492099 cites W2965102054 @default.
- W4280492099 cites W2966612446 @default.
- W4280492099 cites W2969289726 @default.
- W4280492099 cites W2971126595 @default.
- W4280492099 cites W2971402453 @default.
- W4280492099 cites W2971756986 @default.
- W4280492099 cites W2977683219 @default.
- W4280492099 cites W2986569392 @default.
- W4280492099 cites W2988014190 @default.
- W4280492099 cites W2989083977 @default.
- W4280492099 cites W2990599669 @default.
- W4280492099 cites W2990844810 @default.
- W4280492099 cites W2991069269 @default.
- W4280492099 cites W2991303558 @default.
- W4280492099 cites W2994758603 @default.
- W4280492099 cites W3000361261 @default.
- W4280492099 cites W3000592224 @default.
- W4280492099 cites W3003526695 @default.
- W4280492099 cites W3004181286 @default.
- W4280492099 cites W3004297876 @default.
- W4280492099 cites W3005961053 @default.
- W4280492099 cites W3006194842 @default.
- W4280492099 cites W3008585479 @default.
- W4280492099 cites W3011235549 @default.
- W4280492099 cites W3013276190 @default.
- W4280492099 cites W3021610682 @default.
- W4280492099 cites W3077281576 @default.
- W4280492099 cites W3084269058 @default.
- W4280492099 cites W3090486291 @default.
- W4280492099 cites W3107533236 @default.
- W4280492099 cites W3108389912 @default.
- W4280492099 cites W3109926818 @default.
- W4280492099 cites W3110253137 @default.
- W4280492099 cites W3112492193 @default.
- W4280492099 cites W3115235573 @default.
- W4280492099 cites W3122576841 @default.
- W4280492099 cites W3126783645 @default.
- W4280492099 cites W3128275551 @default.
- W4280492099 cites W3128430006 @default.
- W4280492099 cites W3128646645 @default.
- W4280492099 cites W3131341872 @default.
- W4280492099 cites W3151408999 @default.
- W4280492099 cites W3155823479 @default.
- W4280492099 cites W3160354488 @default.
- W4280492099 cites W3163310202 @default.
- W4280492099 cites W3164921344 @default.
- W4280492099 cites W3170693701 @default.
- W4280492099 cites W3176355676 @default.
- W4280492099 cites W3176534291 @default.