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• W4280500212 abstract "Abstract Background According to international guidelines, Human Papillomavirus (HPV) DNA tests represent a valid alternative to Pap Test for primary cervical cancer screening, provided that they guarantee balanced clinical sensitivity and specificity for cervical intraepithelial neoplasia grade 2 or more (CIN2+) lesions. The study aimed to assess whether HPV Selfy (Ulisse BioMed – Trieste, Italy), a full-genotyping HPV DNA test that detects and differentiates 14 high-risk HPV (HR-HPV) types, meets the criteria for primary cervical cancer screening described in the international guidelines, on clinician-collected as well as on self-collected samples. Methods For each participant woman, consecutively referring to Azienda Sanitaria Universitaria Giuliano Isontina (Trieste, Italy) and CRO—National Cancer Institute (Aviano, Italy) for the cervical cancer screening program, the following samples were tested: (a) a clinician-collected cervical specimen, analyzed with the reference test (Hybrid Capture®2 test, HC2) and HPV Selfy; and (b) a self-collected vaginal sample, analyzed with HPV Selfy. Enrolled women were also asked to fulfill a questionnaire about self-sampling acceptability. As required by guidelines, a non-inferiority test was conducted to compare the clinical performance of the test under evaluation with its reference test. Results HPV Selfy clinical sensitivity and specificity resulted non-inferior to those of HC2. By analysis of a total of 889 cervical liquid-based cytology samples from a screening population, of which 98 were from women with CIN2+, HPV Selfy showed relative sensitivity and specificity for CIN2+ of 0.98 and 1.00 respectively (non-inferiority score test: P = 0.01747 and P = 0.00414, respectively); the test reached adequate intra- and inter-laboratory reproducibility. Moreover, we demonstrated that the performance of HPV Selfy on self-collected vaginal samples was non-inferior to the performance obtained on clinician-collected cervical specimen (0.92 relative sensitivity and 0.97 relative specificity). Finally, through HPV Selfy genotyping, we were able to describe HPV types prevalence in the study population. Conclusions HPV Selfy fulfills all the requirements of the international Meijer’s guidelines and has been clinically validated for primary cervical cancer screening purposes. Moreover, HPV Selfy has also been validated for self-sampling according to VALHUDES guidelines. Therefore, at date, HPV Selfy is the only full-genotyping test validated both for screening purposes and for self-sampling. Trial registration ASUGI Trieste n. 16008/2018; CRO Aviano n.17149/2018" @default.
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• W4280500212 date "2022-05-17" @default.
• W4280500212 modified "2023-09-25" @default.
• W4280500212 title "Clinical validation of full HR-HPV genotyping HPV Selfy assay according to the international guidelines for HPV test requirements for cervical cancer screening on clinician-collected and self-collected samples" @default.
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• W4280500212 cites W1987350137 @default.
• W4280500212 cites W1989853314 @default.
• W4280500212 cites W1996007109 @default.
• W4280500212 cites W2002724910 @default.
• W4280500212 cites W2009387166 @default.
• W4280500212 cites W2017554996 @default.
• W4280500212 cites W2017599002 @default.
• W4280500212 cites W2025017506 @default.
• W4280500212 cites W2039728969 @default.
• W4280500212 cites W2047403928 @default.
• W4280500212 cites W2054969461 @default.
• W4280500212 cites W2055327161 @default.
• W4280500212 cites W2067091245 @default.
• W4280500212 cites W2067525947 @default.
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• W4280500212 cites W2079559869 @default.
• W4280500212 cites W2095250514 @default.
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• W4280500212 cites W2130602337 @default.
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• W4280500212 cites W2140366237 @default.
• W4280500212 cites W2148585388 @default.
• W4280500212 cites W2150416461 @default.
• W4280500212 cites W2165412776 @default.
• W4280500212 cites W2169296480 @default.
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• W4280500212 cites W2478912775 @default.
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• W4280500212 doi "https://doi.org/10.1186/s12967-022-03383-x" @default.
• W4280500212 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35581584" @default.
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