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- W4283264893 endingPage "6879" @default.
- W4283264893 startingPage "6879" @default.
- W4283264893 abstract "Glioblastoma multiforme is a lethal disease and represents the most common and severe type of glioma. Drug resistance and the evasion of cell death are the main characteristics of its malignancy, leading to a high percentage of disease recurrence and the patients' low survival rate. Exploiting the modulation of cell death mechanisms could be an important strategy to prevent tumor development and reverse the high mortality and morbidity rates in glioblastoma patients. Ferroptosis is a recently described type of cell death, which is characterized by iron accumulation, high levels of polyunsaturated fatty acid (PUFA)-containing phospholipids, and deficiency in lipid peroxidation repair. Several studies have demonstrated that ferroptosis has a potential role in cancer treatment and could be a promising approach for glioblastoma patients. Thus, here, we present an overview of the mechanisms of the iron-dependent cell death and summarize the current findings of ferroptosis modulation on glioblastoma including its non-canonical pathway. Moreover, we focused on new ferroptosis-inducing compounds for glioma treatment, and we highlight the key ferroptosis-related genes to glioma prognosis, which could be further explored. Thereby, understanding how to trigger ferroptosis in glioblastoma may provide promising pharmacological targets and indicate new therapeutic approaches to increase the survival of glioblastoma patients." @default.
- W4283264893 created "2022-06-23" @default.
- W4283264893 creator A5002321293 @default.
- W4283264893 creator A5006395053 @default.
- W4283264893 creator A5034210245 @default.
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- W4283264893 creator A5074393945 @default.
- W4283264893 creator A5088737634 @default.
- W4283264893 creator A5089944654 @default.
- W4283264893 date "2022-06-21" @default.
- W4283264893 modified "2023-10-06" @default.
- W4283264893 title "Ferroptosis Modulation: Potential Therapeutic Target for Glioblastoma Treatment" @default.
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