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- W4283697410 abstract "Purpose Multiple sclerosis (MS) is an immune-mediated, neuroinflammatory disease of the central nervous system and in industrialised countries is the most common cause of progressive neurological disability in working age persons. While treatable, there is substantial interindividual heterogeneity in disease activity and response to treatment. Currently, the ability to predict at diagnosis who will have a benign, intermediate or aggressive disease course is very limited. There is, therefore, a need for integrated predictive tools to inform individualised treatment decision making. Participants Established with the aim of addressing this need for individualised predictive tools, FutureMS is a nationally representative, prospective observational cohort study of 440 adults with a new diagnosis of relapsing-remitting MS living in Scotland at the time of diagnosis between May 2016 and March 2019. Findings to date The study aims to explore the pathobiology and determinants of disease heterogeneity in MS and combines detailed clinical phenotyping with imaging, genetic and biomarker metrics of disease activity and progression. Recruitment, baseline assessment and follow-up at year 1 is complete. Here, we describe the cohort design and present a profile of the participants at baseline and 1 year of follow-up. Future plans A third follow-up wave for the cohort has recently begun at 5 years after first visit and a further wave of follow-up is funded for year 10. Longer-term follow-up is anticipated thereafter." @default.
- W4283697410 created "2022-06-30" @default.
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- W4283697410 date "2022-06-01" @default.
- W4283697410 modified "2023-10-01" @default.
- W4283697410 title "FutureMS cohort profile: a Scottish multicentre inception cohort study of relapsing-remitting multiple sclerosis" @default.
- W4283697410 cites W1542362250 @default.
- W4283697410 cites W1969682776 @default.
- W4283697410 cites W2000940736 @default.
- W4283697410 cites W2004963280 @default.
- W4283697410 cites W2012350550 @default.
- W4283697410 cites W2017507551 @default.
- W4283697410 cites W2018333705 @default.
- W4283697410 cites W2018693879 @default.
- W4283697410 cites W2021702313 @default.
- W4283697410 cites W2025055179 @default.
- W4283697410 cites W2025694051 @default.
- W4283697410 cites W2038635496 @default.
- W4283697410 cites W2040547343 @default.
- W4283697410 cites W2041550772 @default.
- W4283697410 cites W2041692743 @default.
- W4283697410 cites W2043705607 @default.
- W4283697410 cites W2046451999 @default.
- W4283697410 cites W2046817896 @default.
- W4283697410 cites W2058583207 @default.
- W4283697410 cites W2062408431 @default.
- W4283697410 cites W2076460622 @default.
- W4283697410 cites W2078052727 @default.
- W4283697410 cites W2086164539 @default.
- W4283697410 cites W2094248261 @default.
- W4283697410 cites W2096200224 @default.
- W4283697410 cites W2097146819 @default.
- W4283697410 cites W2099133516 @default.
- W4283697410 cites W2100686623 @default.
- W4283697410 cites W2102104470 @default.
- W4283697410 cites W2103758700 @default.
- W4283697410 cites W2105167551 @default.
- W4283697410 cites W2114242035 @default.
- W4283697410 cites W2122545833 @default.
- W4283697410 cites W2126737632 @default.
- W4283697410 cites W2129276106 @default.
- W4283697410 cites W2129720713 @default.
- W4283697410 cites W2129757393 @default.
- W4283697410 cites W2132322340 @default.
- W4283697410 cites W2138416982 @default.
- W4283697410 cites W2139204856 @default.
- W4283697410 cites W2141111992 @default.
- W4283697410 cites W2142539946 @default.
- W4283697410 cites W2142577589 @default.
- W4283697410 cites W2144665769 @default.
- W4283697410 cites W2146798707 @default.
- W4283697410 cites W2146853725 @default.
- W4283697410 cites W2148186809 @default.
- W4283697410 cites W2148563799 @default.
- W4283697410 cites W2148677082 @default.
- W4283697410 cites W2148766438 @default.
- W4283697410 cites W2151185538 @default.
- W4283697410 cites W2152381343 @default.
- W4283697410 cites W2158202057 @default.
- W4283697410 cites W2164392039 @default.
- W4283697410 cites W2169276442 @default.
- W4283697410 cites W2172271216 @default.
- W4283697410 cites W2331089720 @default.
- W4283697410 cites W2397582608 @default.
- W4283697410 cites W2411811070 @default.
- W4283697410 cites W2474629559 @default.
- W4283697410 cites W2476223773 @default.
- W4283697410 cites W2500526526 @default.
- W4283697410 cites W2583347849 @default.
- W4283697410 cites W2622684067 @default.
- W4283697410 cites W2737252033 @default.
- W4283697410 cites W2763147694 @default.
- W4283697410 cites W2767646038 @default.
- W4283697410 cites W2777074421 @default.
- W4283697410 cites W2802344146 @default.
- W4283697410 cites W2911647303 @default.