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- W4285087304 abstract "Protein ubiquitination with general existence in virtually all eukaryotic cells serves as a significant post-translational modification of cellular proteins, which leads to the degradation of proteins via the ubiquitin-proteasome system. Deubiquitinating enzymes (DUBs) can reverse the ubiquitination effect by removing the ubiquitin chain from the target protein. Together, these two processes participate in regulating protein stability, function, and localization, thus modulating cell cycle, DNA repair, autophagy, and transcription regulation. Accumulating evidence indicates that the ubiquitination/deubiquitination system regulates reproductive processes, including the cell cycle, oocyte maturation, oocyte-sperm binding, and early embryonic development, primarily by regulating protein stability. This review summarizes the extensive research concerning the role of ubiquitin and DUBs in gametogenesis and early embryonic development, which helps us to understand human pregnancy further." @default.
- W4285087304 created "2022-07-14" @default.
- W4285087304 creator A5008582313 @default.
- W4285087304 creator A5031436437 @default.
- W4285087304 creator A5036540274 @default.
- W4285087304 creator A5063499064 @default.
- W4285087304 creator A5082116190 @default.
- W4285087304 creator A5086664284 @default.
- W4285087304 date "2022-07-13" @default.
- W4285087304 modified "2023-09-26" @default.
- W4285087304 title "The Conceivable Functions of Protein Ubiquitination and Deubiquitination in Reproduction" @default.
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