Matches in SemOpenAlex for { <https://semopenalex.org/work/W4285092046> ?p ?o ?g. }
- W4285092046 abstract "In light of the limited number of targetable oncogenic drivers in breast cancer (BRCA), it is important to identify effective and druggable gene targets for the treatment of this devastating disease. Herein, the GSE102484 dataset containing expression profiling data from 683 BRCA patients was re-analyzed using weighted gene co-expression network analysis (WGCNA). The yellow module with the highest correlation to BRCA progression was screened out, followed by functional enrichment analysis and establishment of a protein–protein interaction (PPI) network. After further validation through survival analysis and expression evaluation, CHEK1 and UBE2C were finally identified as hub genes related to the progression of BRCA, especially the luminal A breast cancer subtype. Notably, both hub genes were found to be dysregulated in multiple types of immune cells and closely correlated with tumor infiltration, as revealed by Tumor Immune Estimation Resource (TIMER) along with other bioinformatic tools. Construction of transcription factors (TF)-hub gene network further confirmed the existence of 11 TFs which could regulate both hub genes simultaneously. Our present study may facilitate the invention of targeted therapeutic drugs and provide novel insights into the understanding of the mechanism beneath the progression of BRCA." @default.
- W4285092046 created "2022-07-14" @default.
- W4285092046 creator A5030689783 @default.
- W4285092046 creator A5044150300 @default.
- W4285092046 creator A5047828195 @default.
- W4285092046 creator A5059868960 @default.
- W4285092046 date "2022-07-12" @default.
- W4285092046 modified "2023-10-05" @default.
- W4285092046 title "Integrative Bioinformatics Analysis Reveals CHEK1 and UBE2C as Luminal A Breast Cancer Subtype Biomarkers" @default.
- W4285092046 cites W1939696168 @default.
- W4285092046 cites W1953775089 @default.
- W4285092046 cites W1966327575 @default.
- W4285092046 cites W1971843379 @default.
- W4285092046 cites W1986938347 @default.
- W4285092046 cites W2016307885 @default.
- W4285092046 cites W2019239636 @default.
- W4285092046 cites W2035618305 @default.
- W4285092046 cites W2062533676 @default.
- W4285092046 cites W2119725124 @default.
- W4285092046 cites W2121651329 @default.
- W4285092046 cites W2125197632 @default.
- W4285092046 cites W2129856008 @default.
- W4285092046 cites W2140990686 @default.
- W4285092046 cites W2141393790 @default.
- W4285092046 cites W2155205362 @default.
- W4285092046 cites W2159675211 @default.
- W4285092046 cites W2214665719 @default.
- W4285092046 cites W2607129810 @default.
- W4285092046 cites W2609630616 @default.
- W4285092046 cites W2751875990 @default.
- W4285092046 cites W2752618565 @default.
- W4285092046 cites W2765224588 @default.
- W4285092046 cites W2787091682 @default.
- W4285092046 cites W2795686629 @default.
- W4285092046 cites W2889646458 @default.
- W4285092046 cites W2900569176 @default.
- W4285092046 cites W2912993657 @default.
- W4285092046 cites W2937441321 @default.
- W4285092046 cites W3007991348 @default.
- W4285092046 cites W3027286012 @default.
- W4285092046 cites W3032519533 @default.
- W4285092046 cites W3035186545 @default.
- W4285092046 cites W3047825284 @default.
- W4285092046 cites W3139686968 @default.
- W4285092046 cites W3148394563 @default.
- W4285092046 cites W3165484362 @default.
- W4285092046 cites W3206596800 @default.
- W4285092046 cites W3216213708 @default.
- W4285092046 cites W4200033379 @default.
- W4285092046 cites W4206965224 @default.
- W4285092046 cites W4210632929 @default.
- W4285092046 doi "https://doi.org/10.3389/fgene.2022.944259" @default.
- W4285092046 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35903365" @default.
- W4285092046 hasPublicationYear "2022" @default.
- W4285092046 type Work @default.
- W4285092046 citedByCount "2" @default.
- W4285092046 countsByYear W42850920462023 @default.
- W4285092046 crossrefType "journal-article" @default.
- W4285092046 hasAuthorship W4285092046A5030689783 @default.
- W4285092046 hasAuthorship W4285092046A5044150300 @default.
- W4285092046 hasAuthorship W4285092046A5047828195 @default.
- W4285092046 hasAuthorship W4285092046A5059868960 @default.
- W4285092046 hasBestOaLocation W42850920461 @default.
- W4285092046 hasConcept C104317684 @default.
- W4285092046 hasConcept C121608353 @default.
- W4285092046 hasConcept C502942594 @default.
- W4285092046 hasConcept C530470458 @default.
- W4285092046 hasConcept C54355233 @default.
- W4285092046 hasConcept C60644358 @default.
- W4285092046 hasConcept C70721500 @default.
- W4285092046 hasConcept C71924100 @default.
- W4285092046 hasConcept C86339819 @default.
- W4285092046 hasConcept C86803240 @default.
- W4285092046 hasConceptScore W4285092046C104317684 @default.
- W4285092046 hasConceptScore W4285092046C121608353 @default.
- W4285092046 hasConceptScore W4285092046C502942594 @default.
- W4285092046 hasConceptScore W4285092046C530470458 @default.
- W4285092046 hasConceptScore W4285092046C54355233 @default.
- W4285092046 hasConceptScore W4285092046C60644358 @default.
- W4285092046 hasConceptScore W4285092046C70721500 @default.
- W4285092046 hasConceptScore W4285092046C71924100 @default.
- W4285092046 hasConceptScore W4285092046C86339819 @default.
- W4285092046 hasConceptScore W4285092046C86803240 @default.
- W4285092046 hasLocation W42850920461 @default.
- W4285092046 hasLocation W42850920462 @default.
- W4285092046 hasLocation W42850920463 @default.
- W4285092046 hasOpenAccess W4285092046 @default.
- W4285092046 hasPrimaryLocation W42850920461 @default.
- W4285092046 hasRelatedWork W2009966535 @default.
- W4285092046 hasRelatedWork W2019988726 @default.
- W4285092046 hasRelatedWork W2057841153 @default.
- W4285092046 hasRelatedWork W2082530227 @default.
- W4285092046 hasRelatedWork W2088063203 @default.
- W4285092046 hasRelatedWork W2171277769 @default.
- W4285092046 hasRelatedWork W2297592050 @default.
- W4285092046 hasRelatedWork W3130591221 @default.
- W4285092046 hasRelatedWork W3196332669 @default.
- W4285092046 hasRelatedWork W4365129602 @default.
- W4285092046 hasVolume "13" @default.
- W4285092046 isParatext "false" @default.