Matches in SemOpenAlex for { <https://semopenalex.org/work/W4288045487> ?p ?o ?g. }
- W4288045487 endingPage "8" @default.
- W4288045487 startingPage "1" @default.
- W4288045487 abstract "Malignant tumors are the major cause of death in hemodialysis patients. Management of these patients remains challenging as there is no evidence that chemotherapy is beneficial, and a lack of information about actual clinical practice.This multicenter retrospective study included hemodialysis patients who were diagnosed with lung cancer from January 2002 to June 2018. We reviewed their clinical information including patient characteristics associated with lung cancer and end-stage renal disease, regimen, efficacy and safety of chemotherapy, and outcomes.A total of 162 patients from 22 institutions in Japan were registered. Of 158 eligible patients, 91 received chemotherapy (80 as palliative chemotherapy and 11 as chemoradiotherapy) and 67 received best supportive care only regardless of cancer stage. In small cell lung cancer (SCLC) and non-small cell lung cancer (NSCLC) patients who received cytotoxic chemotherapy, the objective response rates (ORR) and median overall survival (OS) were 68.1 %, 12.3 months and 37.0 %, 8.5 months, respectively. The ORR and median OS in patients with EGFR-mutant NSCLC treated with EGFR-tyrosine kinase inhibitors (TKI) were 44.4 % and 38.6 months. The treatment-related adverse events (Grade 3 or higher) induced by cytotoxic chemotherapy were myelosuppression and febrile neutropenia; treatment-related death (TRD) was observed in one patient. TRD occurred in 3 of 18 patients who received EGFR-TKI.Chemotherapy should be considered for hemodialysis patients with EGFR-mutant NSCLC and SCLC. However, the survival benefits of chemotherapy for NSCLC patients with EGFR-wild type are unclear; physicians should carefully consider whether to offer chemotherapy to this patient subset." @default.
- W4288045487 created "2022-07-27" @default.
- W4288045487 creator A5002493998 @default.
- W4288045487 creator A5003529714 @default.
- W4288045487 creator A5006974520 @default.
- W4288045487 creator A5007607688 @default.
- W4288045487 creator A5021573729 @default.
- W4288045487 creator A5023225309 @default.
- W4288045487 creator A5024253530 @default.
- W4288045487 creator A5029655825 @default.
- W4288045487 creator A5032063684 @default.
- W4288045487 creator A5040162534 @default.
- W4288045487 creator A5041037038 @default.
- W4288045487 creator A5044347263 @default.
- W4288045487 creator A5046914207 @default.
- W4288045487 creator A5048704135 @default.
- W4288045487 creator A5054938771 @default.
- W4288045487 creator A5057773523 @default.
- W4288045487 creator A5065652494 @default.
- W4288045487 creator A5066733858 @default.
- W4288045487 creator A5070801389 @default.
- W4288045487 creator A5072875054 @default.
- W4288045487 creator A5073179957 @default.
- W4288045487 creator A5078192333 @default.
- W4288045487 creator A5078721365 @default.
- W4288045487 creator A5089131312 @default.
- W4288045487 creator A5063242382 @default.
- W4288045487 date "2022-10-01" @default.
- W4288045487 modified "2023-10-01" @default.
- W4288045487 title "Real-world outcomes of chemotherapy for lung cancer patients undergoing hemodialysis: A multicenter retrospective cohort study (NEJ-042)" @default.
- W4288045487 cites W1987380247 @default.
- W4288045487 cites W2007494957 @default.
- W4288045487 cites W2059050919 @default.
- W4288045487 cites W2090486459 @default.
- W4288045487 cites W2107557406 @default.
- W4288045487 cites W2132872400 @default.
- W4288045487 cites W2133169646 @default.
- W4288045487 cites W2133396456 @default.
- W4288045487 cites W2171990964 @default.
- W4288045487 cites W2218839371 @default.
- W4288045487 cites W2434614187 @default.
- W4288045487 cites W2554947920 @default.
- W4288045487 cites W2559181487 @default.
- W4288045487 cites W2736523491 @default.
- W4288045487 cites W2788177282 @default.
- W4288045487 cites W2802155618 @default.
- W4288045487 cites W2897541686 @default.
- W4288045487 cites W2971750275 @default.
- W4288045487 cites W2972951159 @default.
- W4288045487 cites W2995590823 @default.
- W4288045487 cites W3031410799 @default.
- W4288045487 cites W4239714259 @default.
- W4288045487 doi "https://doi.org/10.1016/j.lungcan.2022.07.009" @default.
- W4288045487 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35952438" @default.
- W4288045487 hasPublicationYear "2022" @default.
- W4288045487 type Work @default.
- W4288045487 citedByCount "1" @default.
- W4288045487 countsByYear W42880454872022 @default.
- W4288045487 crossrefType "journal-article" @default.
- W4288045487 hasAuthorship W4288045487A5002493998 @default.
- W4288045487 hasAuthorship W4288045487A5003529714 @default.
- W4288045487 hasAuthorship W4288045487A5006974520 @default.
- W4288045487 hasAuthorship W4288045487A5007607688 @default.
- W4288045487 hasAuthorship W4288045487A5021573729 @default.
- W4288045487 hasAuthorship W4288045487A5023225309 @default.
- W4288045487 hasAuthorship W4288045487A5024253530 @default.
- W4288045487 hasAuthorship W4288045487A5029655825 @default.
- W4288045487 hasAuthorship W4288045487A5032063684 @default.
- W4288045487 hasAuthorship W4288045487A5040162534 @default.
- W4288045487 hasAuthorship W4288045487A5041037038 @default.
- W4288045487 hasAuthorship W4288045487A5044347263 @default.
- W4288045487 hasAuthorship W4288045487A5046914207 @default.
- W4288045487 hasAuthorship W4288045487A5048704135 @default.
- W4288045487 hasAuthorship W4288045487A5054938771 @default.
- W4288045487 hasAuthorship W4288045487A5057773523 @default.
- W4288045487 hasAuthorship W4288045487A5063242382 @default.
- W4288045487 hasAuthorship W4288045487A5065652494 @default.
- W4288045487 hasAuthorship W4288045487A5066733858 @default.
- W4288045487 hasAuthorship W4288045487A5070801389 @default.
- W4288045487 hasAuthorship W4288045487A5072875054 @default.
- W4288045487 hasAuthorship W4288045487A5073179957 @default.
- W4288045487 hasAuthorship W4288045487A5078192333 @default.
- W4288045487 hasAuthorship W4288045487A5078721365 @default.
- W4288045487 hasAuthorship W4288045487A5089131312 @default.
- W4288045487 hasConcept C121608353 @default.
- W4288045487 hasConcept C126322002 @default.
- W4288045487 hasConcept C143998085 @default.
- W4288045487 hasConcept C167135981 @default.
- W4288045487 hasConcept C2776256026 @default.
- W4288045487 hasConcept C2776694085 @default.
- W4288045487 hasConcept C2777063308 @default.
- W4288045487 hasConcept C2778063415 @default.
- W4288045487 hasConcept C2778336483 @default.
- W4288045487 hasConcept C2778850193 @default.
- W4288045487 hasConcept C2781413609 @default.
- W4288045487 hasConcept C71924100 @default.
- W4288045487 hasConceptScore W4288045487C121608353 @default.
- W4288045487 hasConceptScore W4288045487C126322002 @default.