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- W4289766615 abstract "Abstract Genomic data provide valuable insights into pest management issues such as resistance evolution, historical patterns of pest invasions and ongoing population dynamics. We assembled the first reference genome for the redlegged earth mite, Halotydeus destructor (Tucker, 1925), to investigate adaptation to pesticide pressures and demography in its invasive Australian range using whole-genome pool-seq data from regionally distributed populations. Our reference genome comprises 132 autosomal contigs, with a total length of 48.90 Mb. We observed a large complex of ace genes, which has presumably evolved from a long history of organophosphate selection in H. destructor and may contribute toward organophosphate resistance through copy number variation, target-site mutations, and structural variants. In the putative ancestral H. destructor ace gene, we identified three target-site mutations (G119S, A201S, and F331Y) segregating in organophosphate resistant populations. Additionally, we identified two new para sodium channel gene mutations (L925I and F1020Y) that may contribute to pyrethroid resistance. Regional structuring observed in population genomic analyses indicates that gene flow in H. destructor does not homogenise populations across large geographic distances. However, our demographic analyses were equivocal on the magnitude of gene flow; the short invasion history of H. destructor makes it difficult to distinguish scenarios of complete isolation vs. ongoing migration. Nonetheless, we identified clear signatures of reduced genetic diversity and smaller inferred effective population sizes in eastern vs. western populations, which is consistent with the stepping-stone invasion pathway of this pest in Australia. These new insights will inform development of diagnostic genetic markers of resistance, further investigation into the multifaceted organophosphate resistance mechanism, and predictive modelling of resistance evolution and spread." @default.
- W4289766615 created "2022-08-04" @default.
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- W4289766615 date "2022-08-04" @default.
- W4289766615 modified "2023-10-12" @default.
- W4289766615 title "The redlegged earth mite draft genome provides new insights into pesticide resistance evolution and demography in its invasive Australian range" @default.
- W4289766615 cites W1534912033 @default.
- W4289766615 cites W1827155284 @default.
- W4289766615 cites W1917336968 @default.
- W4289766615 cites W1929705259 @default.
- W4289766615 cites W1951724000 @default.
- W4289766615 cites W1965735290 @default.
- W4289766615 cites W1973390101 @default.
- W4289766615 cites W1974116356 @default.
- W4289766615 cites W1978738003 @default.
- W4289766615 cites W1983678254 @default.
- W4289766615 cites W1987502745 @default.
- W4289766615 cites W1992909979 @default.
- W4289766615 cites W1994429698 @default.
- W4289766615 cites W1998767819 @default.
- W4289766615 cites W2001338440 @default.
- W4289766615 cites W2013110849 @default.
- W4289766615 cites W2015237286 @default.
- W4289766615 cites W2020953156 @default.
- W4289766615 cites W2021141322 @default.
- W4289766615 cites W2022366078 @default.
- W4289766615 cites W2023270829 @default.
- W4289766615 cites W2024086677 @default.
- W4289766615 cites W2038090718 @default.
- W4289766615 cites W2042160423 @default.
- W4289766615 cites W2043789665 @default.
- W4289766615 cites W2044658037 @default.
- W4289766615 cites W2047369469 @default.
- W4289766615 cites W2048691480 @default.
- W4289766615 cites W2049228937 @default.
- W4289766615 cites W2061434689 @default.
- W4289766615 cites W2064015470 @default.
- W4289766615 cites W2078716122 @default.
- W4289766615 cites W2083239248 @default.
- W4289766615 cites W2090938238 @default.
- W4289766615 cites W2096549168 @default.
- W4289766615 cites W2098899569 @default.
- W4289766615 cites W2108234281 @default.
- W4289766615 cites W2112504441 @default.
- W4289766615 cites W2125300654 @default.
- W4289766615 cites W2126419817 @default.
- W4289766615 cites W2130179644 @default.
- W4289766615 cites W2130253098 @default.
- W4289766615 cites W2149992227 @default.
- W4289766615 cites W2150131459 @default.
- W4289766615 cites W2151138104 @default.
- W4289766615 cites W2151409320 @default.
- W4289766615 cites W2155628349 @default.
- W4289766615 cites W2158196600 @default.
- W4289766615 cites W2164154943 @default.
- W4289766615 cites W2168862262 @default.
- W4289766615 cites W2232237847 @default.
- W4289766615 cites W2296083684 @default.
- W4289766615 cites W2553804235 @default.
- W4289766615 cites W2560653535 @default.
- W4289766615 cites W2568852212 @default.
- W4289766615 cites W2587454003 @default.
- W4289766615 cites W2774486220 @default.
- W4289766615 cites W2774788690 @default.
- W4289766615 cites W2774817295 @default.
- W4289766615 cites W2793742055 @default.
- W4289766615 cites W2795091386 @default.
- W4289766615 cites W2898796699 @default.
- W4289766615 cites W2900991893 @default.
- W4289766615 cites W2902745421 @default.
- W4289766615 cites W2936504243 @default.
- W4289766615 cites W2949086752 @default.
- W4289766615 cites W2950584125 @default.
- W4289766615 cites W2951912016 @default.
- W4289766615 cites W2954705972 @default.
- W4289766615 cites W2972512404 @default.
- W4289766615 cites W3048048159 @default.
- W4289766615 cites W3087648251 @default.
- W4289766615 cites W3094601547 @default.
- W4289766615 cites W3110842850 @default.
- W4289766615 cites W3112247157 @default.
- W4289766615 cites W3131055609 @default.
- W4289766615 cites W3131614060 @default.
- W4289766615 cites W3136308181 @default.
- W4289766615 cites W3159728495 @default.
- W4289766615 cites W3202746593 @default.
- W4289766615 cites W4210340740 @default.
- W4289766615 cites W4281262067 @default.
- W4289766615 cites W4281296330 @default.
- W4289766615 cites W4289766615 @default.
- W4289766615 doi "https://doi.org/10.1101/2022.08.03.502713" @default.
- W4289766615 hasPublicationYear "2022" @default.