FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4290964328> ?p ?o ?g. }

• W4290964328 abstract "Familial adenomatous polyposis (FAP) is a rare autosomal dominant disease characterized by germline mutations in the Adenomatous Polyposis Coli (APC) gene, resulting in the development of numerous colorectal adenomas. As these patients have a high risk of developing colorectal cancer (CRC), guidelines suggest prophylactic colectomy during early adulthood, however, adenoma development is still observed in the remaining intestinal tract. Therefore, FAP patients would benefit from chemoprevention strategies reducing the development of adenomas. Recent work in mice reveals a chemopreventive effect of lithium on the development of adenomas by inhibiting the expansion of Apc mutated intestinal stem cells (ISCs) within the crypts of normal intestinal mucosa. Here, we aim to investigate the effect of lithium on the spread of APC mutant cells within the human intestinal epithelium.This prospective phase II single arm trial has a duration of 18 months. FAP patients (18-35 years) with a genetically confirmed APC mutation who did not undergo colectomy will be treated with lithium carbonate orally achieving a serum level of 0.2-0.4 mmol/l between month 6 and 12. Colonoscopy with biopsies of normal intestinal mucosa will be performed at baseline and every six months. The primary endpoint is the effect of lithium on the spread of APC mutant cells within intestinal crypts over time by using APC specific marker NOTUM in situ hybridization. Secondary endpoints include change in adenoma burden, patient reported side effects and safety-outcomes. Total sample size is 12 patients and recruitment will take place in the Amsterdam UMC, location AMC in the Netherlands.The outcome of this study will function as a proof-of-concept for the development of novel chemoprevention approaches that interfere with the competition between normal and mutant ISCs.ClinicalTrials.gov ( https://clinicaltrials.gov/ ): NCT05402891 (June 1, 2022) and the EU Clinical Trials Register: EuraCT 2022-000240-30 (January 1, 2022)." @default.
• W4290964328 created "2022-08-13" @default.
• W4290964328 creator A5002930312 @default.
• W4290964328 creator A5003514273 @default.
• W4290964328 creator A5036684697 @default.
• W4290964328 creator A5039493798 @default.
• W4290964328 creator A5043831964 @default.
• W4290964328 creator A5063106896 @default.
• W4290964328 date "2022-08-12" @default.
• W4290964328 modified "2023-10-06" @default.
• W4290964328 title "The CHAMP-study: the CHemopreventive effect of lithium in familial AdenoMatous Polyposis; study protocol of a phase II trial" @default.
• W4290964328 cites W1490250257 @default.
• W4290964328 cites W1968969468 @default.
• W4290964328 cites W1976270786 @default.
• W4290964328 cites W1981524857 @default.
• W4290964328 cites W1988623463 @default.
• W4290964328 cites W2046389333 @default.
• W4290964328 cites W2059813946 @default.
• W4290964328 cites W2088202309 @default.
• W4290964328 cites W2131729719 @default.
• W4290964328 cites W2286792260 @default.
• W4290964328 cites W2336169581 @default.
• W4290964328 cites W2342356002 @default.
• W4290964328 cites W2465989363 @default.
• W4290964328 cites W2610823330 @default.
• W4290964328 cites W2789271913 @default.
• W4290964328 cites W2944179838 @default.
• W4290964328 cites W2963818486 @default.
• W4290964328 cites W2976026968 @default.
• W4290964328 cites W3084327256 @default.
• W4290964328 cites W3117602214 @default.
• W4290964328 cites W3165366231 @default.
• W4290964328 cites W3165875563 @default.
• W4290964328 cites W3176438685 @default.
• W4290964328 cites W3188167692 @default.
• W4290964328 cites W4210641896 @default.
• W4290964328 cites W4290964328 @default.
• W4290964328 doi "https://doi.org/10.1186/s12876-022-02442-3" @default.
• W4290964328 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35962368" @default.
• W4290964328 hasPublicationYear "2022" @default.
• W4290964328 type Work @default.
• W4290964328 citedByCount "3" @default.
• W4290964328 countsByYear W42909643282022 @default.
• W4290964328 countsByYear W42909643282023 @default.
• W4290964328 crossrefType "journal-article" @default.
• W4290964328 hasAuthorship W4290964328A5002930312 @default.
• W4290964328 hasAuthorship W4290964328A5003514273 @default.
• W4290964328 hasAuthorship W4290964328A5036684697 @default.
• W4290964328 hasAuthorship W4290964328A5039493798 @default.
• W4290964328 hasAuthorship W4290964328A5043831964 @default.
• W4290964328 hasAuthorship W4290964328A5063106896 @default.
• W4290964328 hasBestOaLocation W42909643281 @default.
• W4290964328 hasConcept C121608353 @default.
• W4290964328 hasConcept C126322002 @default.
• W4290964328 hasConcept C142724271 @default.
• W4290964328 hasConcept C143998085 @default.
• W4290964328 hasConcept C2776667177 @default.
• W4290964328 hasConcept C2777428134 @default.
• W4290964328 hasConcept C2778237340 @default.
• W4290964328 hasConcept C2778435480 @default.
• W4290964328 hasConcept C2780814781 @default.
• W4290964328 hasConcept C3019368612 @default.
• W4290964328 hasConcept C41260117 @default.
• W4290964328 hasConcept C526805850 @default.
• W4290964328 hasConcept C71924100 @default.
• W4290964328 hasConcept C90924648 @default.
• W4290964328 hasConceptScore W4290964328C121608353 @default.
• W4290964328 hasConceptScore W4290964328C126322002 @default.
• W4290964328 hasConceptScore W4290964328C142724271 @default.
• W4290964328 hasConceptScore W4290964328C143998085 @default.
• W4290964328 hasConceptScore W4290964328C2776667177 @default.
• W4290964328 hasConceptScore W4290964328C2777428134 @default.
• W4290964328 hasConceptScore W4290964328C2778237340 @default.
• W4290964328 hasConceptScore W4290964328C2778435480 @default.
• W4290964328 hasConceptScore W4290964328C2780814781 @default.
• W4290964328 hasConceptScore W4290964328C3019368612 @default.
• W4290964328 hasConceptScore W4290964328C41260117 @default.
• W4290964328 hasConceptScore W4290964328C526805850 @default.
• W4290964328 hasConceptScore W4290964328C71924100 @default.
• W4290964328 hasConceptScore W4290964328C90924648 @default.
• W4290964328 hasFunder F4320322777 @default.
• W4290964328 hasIssue "1" @default.
• W4290964328 hasLocation W42909643281 @default.
• W4290964328 hasLocation W42909643282 @default.
• W4290964328 hasLocation W42909643283 @default.
• W4290964328 hasOpenAccess W4290964328 @default.
• W4290964328 hasPrimaryLocation W42909643281 @default.
• W4290964328 hasRelatedWork W2002541251 @default.
• W4290964328 hasRelatedWork W2008471695 @default.
• W4290964328 hasRelatedWork W2016144884 @default.
• W4290964328 hasRelatedWork W2065350476 @default.
• W4290964328 hasRelatedWork W2071909480 @default.
• W4290964328 hasRelatedWork W2121057485 @default.
• W4290964328 hasRelatedWork W2232387468 @default.
• W4290964328 hasRelatedWork W2804968745 @default.
• W4290964328 hasRelatedWork W2882990093 @default.
• W4290964328 hasRelatedWork W4281386529 @default.
• W4290964328 hasVolume "22" @default.
• W4290964328 isParatext "false" @default.
• W4290964328 isRetracted "false" @default.

• next