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- W4297201039 abstract "We tested the effects of chronic stress on cocaine relapse after drug-reinforced responding was suppressed by punishment, an animal model of human relapse after self-imposed abstinence due to the negative consequences of drug use. Male rats displayed greater resistance to punishment than females, but daily stress decreased this resistance. Only female rats with a history of chronic stress displayed increased responding for cocaine cues from abstinence Day 1 to Day 8. Thus, the effects of chronic stress on punished cocaine self-administration and cue-induced relapse are dependent on biological sex, and may have implications for more targeted treatments for cocaine addiction." @default.
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- W4297201039 date "2022-12-01" @default.
- W4297201039 modified "2023-09-27" @default.
- W4297201039 title "Sex-dependent effects of chronic stress on punished cocaine self-administration and cue-induced relapse to cocaine seeking" @default.
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- W4297201039 doi "https://doi.org/10.1016/j.physbeh.2022.113972" @default.
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