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- W4308016337 abstract "MLL gene rearrangement is a common genetic abnormality of acute myeloid leukemia (AML), which predicts poor prognosis and is important in clinical diagnosis. MLL rearrangement involves many chromosomes, among which, t(4;11) translocation is rare in AML. The present case was t(4;11) AML, accompanied by a hyperdiploid karyotype. Such cases have not been reported previously.An adult male with self-reported symptoms of fatigue, febrility and hyperleukocytosis was diagnosed with AML by morphology and confirmed by immunophenotype analysis. Uncommonly, chromosomal and fluorescence in situ hybridization (FISH) analysis showed a hyperdiploid karyotype with t(4;11) translocation and MLL rearrangement, and a negative MLL-AF4 fusion gene result. The patient died of respiratory and circulatory failure 5 days after diagnosis.t(4;11) AML with hyperdiploid karyotype has not been reported. In this case, t(4;11) was only detected by karyotype analysis and FISH, suggesting their importance in MLL rearrangement detection." @default.
- W4308016337 created "2022-11-07" @default.
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- W4308016337 date "2022-11-16" @default.
- W4308016337 modified "2023-09-26" @default.
- W4308016337 title "t(4;11) translocation in hyperdiploid <i>de novo </i>adult acute myeloid leukemia: A case report" @default.
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- W4308016337 doi "https://doi.org/10.12998/wjcc.v10.i32.11980" @default.
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