Matches in SemOpenAlex for { <https://semopenalex.org/work/W4308687091> ?p ?o ?g. }
- W4308687091 endingPage "039463202211374" @default.
- W4308687091 startingPage "039463202211374" @default.
- W4308687091 abstract "Particulate matter 2.5 (PM2.5)-induced pulmonary inflammation is an important issue worldwide. NLRP3 inflammasome activation has been found to be involved in pulmonary inflammation development. However, whether PM2.5 induces pulmonary inflammation by activating the NLRP3 inflammasome has not yet been fully elucidated. This study researched whether PM2.5 induces the NLRP3 inflammasomes activation to trigger pulmonary inflammation.Mice and MH-S cells were exposed to PM2.5, BOX5, and Rapamycin. Hematoxylin and eosin staining was performed on the lung tissues of mice. M1 macrophage marker CD80 expression in the lung tissues of mice and LC3B expression in MH-S cells was detected by immunofluorescence. IL-1β level in the lavage fluid and MH-S cells were detected by enzyme-linked immunosorbent assay. Protein expression was detected by Western blot. Autophagy assay in MH-S cells was performed by LC3B-GFP punctae experiment.PM2.5 exposure induced the lung injury of mice and increased NLRP3, P62, Wnt5a, LC3BII/I, and CD80 expression and IL-1β release in the lung tissues. PM2.5 treatment increased NLRP3, pro-caspase-1, cleaved caspase-1, Pro-IL-1β, Pro-IL-18, P62, LC3BII/I, and Wnt5a expression, IL-1β release, and LC3B-GFP punctae in MH-S cells. However, BOX5 treatment counteracted this effect of PM2.5 on lung tissues of mice and MH-S cells. Rapamycin reversed the effect of BOX5 on PM2.5-induced lung tissues of mice and MH-S cells.PM2.5 activated the NLRP3 inflammasome and IL-1β release in MH-S cells by facilitating the autophagy via activating Wnt5a. The findings of this study provided a new clue for the treatment of pulmonary inflammation caused by PM2.5." @default.
- W4308687091 created "2022-11-14" @default.
- W4308687091 creator A5002063716 @default.
- W4308687091 creator A5012684882 @default.
- W4308687091 creator A5025650562 @default.
- W4308687091 creator A5049414059 @default.
- W4308687091 creator A5052267876 @default.
- W4308687091 creator A5060622235 @default.
- W4308687091 creator A5069426756 @default.
- W4308687091 date "2022-01-01" @default.
- W4308687091 modified "2023-09-26" @default.
- W4308687091 title "PM2.5 activated NLRP3 inflammasome and IL-1β release in MH-S cells by facilitating autophagy via activating Wnt5a" @default.
- W4308687091 cites W1898335101 @default.
- W4308687091 cites W19905814 @default.
- W4308687091 cites W2042433863 @default.
- W4308687091 cites W2050449334 @default.
- W4308687091 cites W2089503694 @default.
- W4308687091 cites W2126852933 @default.
- W4308687091 cites W2132239682 @default.
- W4308687091 cites W2156271659 @default.
- W4308687091 cites W2190169073 @default.
- W4308687091 cites W2499617807 @default.
- W4308687091 cites W2521751481 @default.
- W4308687091 cites W2522054313 @default.
- W4308687091 cites W2561943186 @default.
- W4308687091 cites W2616442584 @default.
- W4308687091 cites W2758767922 @default.
- W4308687091 cites W2768967814 @default.
- W4308687091 cites W2802217985 @default.
- W4308687091 cites W2806503756 @default.
- W4308687091 cites W2890096825 @default.
- W4308687091 cites W2890738628 @default.
- W4308687091 cites W2893169704 @default.
- W4308687091 cites W2895225647 @default.
- W4308687091 cites W2901671399 @default.
- W4308687091 cites W2912977437 @default.
- W4308687091 cites W2918913212 @default.
- W4308687091 cites W2922220570 @default.
- W4308687091 cites W2957034431 @default.
- W4308687091 cites W2961427932 @default.
- W4308687091 cites W2968610309 @default.
- W4308687091 cites W2972922451 @default.
- W4308687091 cites W2986276869 @default.
- W4308687091 cites W2988106979 @default.
- W4308687091 cites W2988227719 @default.
- W4308687091 cites W3003254885 @default.
- W4308687091 cites W3008570167 @default.
- W4308687091 cites W3009948322 @default.
- W4308687091 cites W3010463873 @default.
- W4308687091 cites W3010580797 @default.
- W4308687091 cites W3010709539 @default.
- W4308687091 cites W3016997101 @default.
- W4308687091 cites W3018271097 @default.
- W4308687091 cites W3021387209 @default.
- W4308687091 cites W3047533219 @default.
- W4308687091 cites W3082518858 @default.
- W4308687091 cites W3082641911 @default.
- W4308687091 cites W3088943738 @default.
- W4308687091 cites W3091342448 @default.
- W4308687091 cites W3091680348 @default.
- W4308687091 cites W3094541269 @default.
- W4308687091 cites W3119214448 @default.
- W4308687091 cites W3167118224 @default.
- W4308687091 cites W3168768156 @default.
- W4308687091 cites W3195196860 @default.
- W4308687091 cites W4205889262 @default.
- W4308687091 cites W4226026355 @default.
- W4308687091 cites W4252285049 @default.
- W4308687091 doi "https://doi.org/10.1177/03946320221137464" @default.
- W4308687091 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36347039" @default.
- W4308687091 hasPublicationYear "2022" @default.
- W4308687091 type Work @default.
- W4308687091 citedByCount "3" @default.
- W4308687091 countsByYear W43086870912023 @default.
- W4308687091 crossrefType "journal-article" @default.
- W4308687091 hasAuthorship W4308687091A5002063716 @default.
- W4308687091 hasAuthorship W4308687091A5012684882 @default.
- W4308687091 hasAuthorship W4308687091A5025650562 @default.
- W4308687091 hasAuthorship W4308687091A5049414059 @default.
- W4308687091 hasAuthorship W4308687091A5052267876 @default.
- W4308687091 hasAuthorship W4308687091A5060622235 @default.
- W4308687091 hasAuthorship W4308687091A5069426756 @default.
- W4308687091 hasBestOaLocation W43086870911 @default.
- W4308687091 hasConcept C104317684 @default.
- W4308687091 hasConcept C126322002 @default.
- W4308687091 hasConcept C153911025 @default.
- W4308687091 hasConcept C154317977 @default.
- W4308687091 hasConcept C185592680 @default.
- W4308687091 hasConcept C190283241 @default.
- W4308687091 hasConcept C202751555 @default.
- W4308687091 hasConcept C203014093 @default.
- W4308687091 hasConcept C203522944 @default.
- W4308687091 hasConcept C2776415932 @default.
- W4308687091 hasConcept C2776914184 @default.
- W4308687091 hasConcept C2777209026 @default.
- W4308687091 hasConcept C2777714996 @default.
- W4308687091 hasConcept C2778297628 @default.
- W4308687091 hasConcept C39347974 @default.