Matches in SemOpenAlex for { <https://semopenalex.org/work/W4309533829> ?p ?o ?g. }
- W4309533829 abstract "Extracellular matrix (ECM) plays a critical role in maintaining elasticity in cardiac tissues. Elasticity is required in the heart for properly pumping blood to the whole body. Dysregulated ECM remodeling causes fibrosis in the cardiac tissues. Cardiac fibrosis leads to stiffness in the heart tissues, resulting in heart failure. During cardiac fibrosis, ECM proteins get excessively deposited in the cardiac tissues. In the ECM, cardiac fibroblast proliferates into myofibroblast upon various kinds of stimulations. Fibroblast activation (myofibroblast) contributes majorly toward cardiac fibrosis. Other than cardiac fibroblasts, cardiomyocytes, epithelial/endothelial cells, and immune system cells can also contribute to cardiac fibrosis. Alteration in the expression of the ECM core and ECM-modifier proteins causes different types of cardiac fibrosis. These different components of ECM culminated into different pathways inducing transdifferentiation of cardiac fibroblast into myofibroblast. In this review, we summarize the role of different ECM components during cardiac fibrosis progression leading to heart failure. Furthermore, we highlight the importance of applying mass-spectrometry-based proteomics to understand the key changes occurring in the ECM during fibrotic progression. Next-gen proteomics studies will broaden the potential to identify key targets to combat cardiac fibrosis in order to achieve precise medicine-development in the future." @default.
- W4309533829 created "2022-11-28" @default.
- W4309533829 creator A5059726366 @default.
- W4309533829 creator A5063586287 @default.
- W4309533829 creator A5089063567 @default.
- W4309533829 date "2022-11-22" @default.
- W4309533829 modified "2023-09-30" @default.
- W4309533829 title "Exploring the cardiac ECM during fibrosis: A new era with next-gen proteomics" @default.
- W4309533829 cites W1507435475 @default.
- W4309533829 cites W1528302249 @default.
- W4309533829 cites W1544527238 @default.
- W4309533829 cites W1573103899 @default.
- W4309533829 cites W1636022999 @default.
- W4309533829 cites W1892184508 @default.
- W4309533829 cites W1929509592 @default.
- W4309533829 cites W1934555946 @default.
- W4309533829 cites W1938666192 @default.
- W4309533829 cites W1959695444 @default.
- W4309533829 cites W1965498876 @default.
- W4309533829 cites W1965667964 @default.
- W4309533829 cites W1968209401 @default.
- W4309533829 cites W1968264871 @default.
- W4309533829 cites W1969393277 @default.
- W4309533829 cites W1969930465 @default.
- W4309533829 cites W1975793355 @default.
- W4309533829 cites W1976468747 @default.
- W4309533829 cites W1977152294 @default.
- W4309533829 cites W1978162436 @default.
- W4309533829 cites W1978310574 @default.
- W4309533829 cites W1979336634 @default.
- W4309533829 cites W1981125871 @default.
- W4309533829 cites W1981421887 @default.
- W4309533829 cites W1981612865 @default.
- W4309533829 cites W1982090891 @default.
- W4309533829 cites W1983283937 @default.
- W4309533829 cites W1984743811 @default.
- W4309533829 cites W1987034289 @default.
- W4309533829 cites W1987929268 @default.
- W4309533829 cites W1988176449 @default.
- W4309533829 cites W1988215184 @default.
- W4309533829 cites W1989905855 @default.
- W4309533829 cites W1990478813 @default.
- W4309533829 cites W1993774985 @default.
- W4309533829 cites W1996310767 @default.
- W4309533829 cites W1997585674 @default.
- W4309533829 cites W2005601959 @default.
- W4309533829 cites W2005629438 @default.
- W4309533829 cites W2006309854 @default.
- W4309533829 cites W2007274239 @default.
- W4309533829 cites W2012795446 @default.
- W4309533829 cites W2013682430 @default.
- W4309533829 cites W2013746298 @default.
- W4309533829 cites W2014289051 @default.
- W4309533829 cites W2015204889 @default.
- W4309533829 cites W2016064855 @default.
- W4309533829 cites W2017049923 @default.
- W4309533829 cites W2019898117 @default.
- W4309533829 cites W2020259352 @default.
- W4309533829 cites W2021091148 @default.
- W4309533829 cites W2022424369 @default.
- W4309533829 cites W2022962151 @default.
- W4309533829 cites W2023096047 @default.
- W4309533829 cites W2024152221 @default.
- W4309533829 cites W2025149824 @default.
- W4309533829 cites W2026196459 @default.
- W4309533829 cites W2028880433 @default.
- W4309533829 cites W2029746173 @default.
- W4309533829 cites W2029883725 @default.
- W4309533829 cites W2031137884 @default.
- W4309533829 cites W2037098024 @default.
- W4309533829 cites W2038569449 @default.
- W4309533829 cites W2039401702 @default.
- W4309533829 cites W2040413836 @default.
- W4309533829 cites W2043497836 @default.
- W4309533829 cites W2044192216 @default.
- W4309533829 cites W2044778696 @default.
- W4309533829 cites W2044793751 @default.
- W4309533829 cites W2046275929 @default.
- W4309533829 cites W2049232777 @default.
- W4309533829 cites W2050862994 @default.
- W4309533829 cites W2051068162 @default.
- W4309533829 cites W2051842535 @default.
- W4309533829 cites W2055875992 @default.
- W4309533829 cites W2060407689 @default.
- W4309533829 cites W2061223357 @default.
- W4309533829 cites W2061777508 @default.
- W4309533829 cites W2061875549 @default.
- W4309533829 cites W2063645267 @default.
- W4309533829 cites W2065497238 @default.
- W4309533829 cites W2065507080 @default.
- W4309533829 cites W2065995788 @default.
- W4309533829 cites W2069911905 @default.
- W4309533829 cites W2070702664 @default.
- W4309533829 cites W2072320843 @default.
- W4309533829 cites W2076583198 @default.
- W4309533829 cites W2076960574 @default.
- W4309533829 cites W2077126162 @default.
- W4309533829 cites W2080811589 @default.
- W4309533829 cites W2084843851 @default.
- W4309533829 cites W2085224134 @default.