FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4313309631> ?p ?o ?g. }

• W4313309631 abstract "Effective monitoring of the physiological progression of acute lung injury (ALI) in real time is crucial for early theranostics to reduce its high mortality. In particular, activatable fluorescence and photoacoustic molecule probes have attracted attention to assess ALI by detecting related indicators. However, the existing fluorophores often encounter issues of low retention in the lungs and slow clearance from the body, which compromise the probe's actual capability for in situ imaging by intravenous injection in vivo. Herein, a novel near-infrared hemicyanines fluorophore (FJH) bearing a quaternary ammonium group was first developed by combining with the rational design and screening strategy. The properties of good hydrophilicity and blood circulation effectively enable FJH accumulation for lung imaging. Inspired by the high retention efficiency, the probe FJH-C that turns on fluorescence and photoacoustic signals in response to the ALI indicator (esterase) was subsequently synthesized. Notably, the probe FJH-C successfully achieved the selectivity and sensitivity toward esterase in vitro and in living cells. More importantly, FJH-C can be further used to assess lipopolysaccharides and silica-induced ALI through the desired fluo-photoacoustic signal. Therefore, this study not only shows the first activatable probe for real-time imaging of lung function but also highlights the fluorophore structure with high lung retention. It is believed that FJH and FJH-C can serve as an efficient platform to reveal the pathological progression of other lung diseases for early diagnosis and medical intervention." @default.
• W4313309631 created "2023-01-06" @default.
• W4313309631 creator A5033023612 @default.
• W4313309631 creator A5038183599 @default.
• W4313309631 creator A5039414614 @default.
• W4313309631 creator A5065409924 @default.
• W4313309631 creator A5069802666 @default.
• W4313309631 date "2022-12-30" @default.
• W4313309631 modified "2023-10-01" @default.
• W4313309631 title "De Novo Design of Activatable Photoacoustic/Fluorescent Probes for Imaging Acute Lung Injury In Vivo" @default.
• W4313309631 cites W1972523784 @default.
• W4313309631 cites W1990819855 @default.
• W4313309631 cites W2008906556 @default.
• W4313309631 cites W2037098558 @default.
• W4313309631 cites W2040282775 @default.
• W4313309631 cites W2127343735 @default.
• W4313309631 cites W2139463252 @default.
• W4313309631 cites W2143463421 @default.
• W4313309631 cites W2170959394 @default.
• W4313309631 cites W2338439820 @default.
• W4313309631 cites W2339634927 @default.
• W4313309631 cites W2413096372 @default.
• W4313309631 cites W2735695517 @default.
• W4313309631 cites W2767090914 @default.
• W4313309631 cites W2783678270 @default.
• W4313309631 cites W2793513555 @default.
• W4313309631 cites W2810653208 @default.
• W4313309631 cites W2811175620 @default.
• W4313309631 cites W2889614246 @default.
• W4313309631 cites W2897221257 @default.
• W4313309631 cites W2936209742 @default.
• W4313309631 cites W2938472446 @default.
• W4313309631 cites W2946216397 @default.
• W4313309631 cites W2955438449 @default.
• W4313309631 cites W2984190376 @default.
• W4313309631 cites W3009776436 @default.
• W4313309631 cites W3021726529 @default.
• W4313309631 cites W3058007974 @default.
• W4313309631 cites W3082535003 @default.
• W4313309631 cites W3088121390 @default.
• W4313309631 cites W3088681065 @default.
• W4313309631 cites W3088922752 @default.
• W4313309631 cites W3094362477 @default.
• W4313309631 cites W3095891761 @default.
• W4313309631 cites W3096832500 @default.
• W4313309631 cites W3114112909 @default.
• W4313309631 cites W3126557310 @default.
• W4313309631 cites W3132488461 @default.
• W4313309631 cites W3154594695 @default.
• W4313309631 cites W3157539725 @default.
• W4313309631 cites W3160527191 @default.
• W4313309631 cites W3175018979 @default.
• W4313309631 cites W3180659190 @default.
• W4313309631 cites W3186360843 @default.
• W4313309631 cites W3189032846 @default.
• W4313309631 cites W3190126363 @default.
• W4313309631 cites W3200381030 @default.
• W4313309631 cites W3203973216 @default.
• W4313309631 cites W3206548671 @default.
• W4313309631 cites W3207648968 @default.
• W4313309631 cites W3211159986 @default.
• W4313309631 cites W3216847055 @default.
• W4313309631 cites W4200343540 @default.
• W4313309631 cites W4206271064 @default.
• W4313309631 cites W4211161945 @default.
• W4313309631 cites W4213412446 @default.
• W4313309631 cites W4214885338 @default.
• W4313309631 cites W4220914048 @default.
• W4313309631 cites W4280499360 @default.
• W4313309631 cites W4280503869 @default.
• W4313309631 cites W4290779542 @default.
• W4313309631 doi "https://doi.org/10.1021/acs.analchem.2c04642" @default.
• W4313309631 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36584357" @default.
• W4313309631 hasPublicationYear "2022" @default.
• W4313309631 type Work @default.
• W4313309631 citedByCount "2" @default.
• W4313309631 countsByYear W43133096312023 @default.
• W4313309631 crossrefType "journal-article" @default.
• W4313309631 hasAuthorship W4313309631A5033023612 @default.
• W4313309631 hasAuthorship W4313309631A5038183599 @default.
• W4313309631 hasAuthorship W4313309631A5039414614 @default.
• W4313309631 hasAuthorship W4313309631A5065409924 @default.
• W4313309631 hasAuthorship W4313309631A5069802666 @default.
• W4313309631 hasConcept C120665830 @default.
• W4313309631 hasConcept C121332964 @default.
• W4313309631 hasConcept C12554922 @default.
• W4313309631 hasConcept C126322002 @default.
• W4313309631 hasConcept C136229726 @default.
• W4313309631 hasConcept C150903083 @default.
• W4313309631 hasConcept C185592680 @default.
• W4313309631 hasConcept C202751555 @default.
• W4313309631 hasConcept C207001950 @default.
• W4313309631 hasConcept C26291073 @default.
• W4313309631 hasConcept C2777714996 @default.
• W4313309631 hasConcept C2778015030 @default.
• W4313309631 hasConcept C2778617687 @default.
• W4313309631 hasConcept C54932901 @default.
• W4313309631 hasConcept C55493867 @default.
• W4313309631 hasConcept C62520636 @default.
• W4313309631 hasConcept C71924100 @default.

• next