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• W4313490625 abstract "Liver transplantation (LT) is the standard surgical definite treatment for end-stage liver disease (ESLD) with different indications encompassing a wide spectrum of liver failure patients with variable clinical profile and status ranging from fulminant to chronic liver failure. It is a high-risk surgery requiring critical vascular volume assessment and fluid management; there are multiple hemodynamic drifts resulting from major blood loss, fluid shifts, and vasomotor tone. Liver transplant recipients suffer many complications, some of which are intervention or approach related. On an average, liver transplant recipients suffer more than three postoperative complications, with over half of them being severe. Perioperative acute renal failure is frequent (13–71%) and is associated with postoperative mortality [1, 2]. Several perioperative events and factors including inappropriate fluid therapy seem associated with the risk of complications ranging from insignificant insult to multiorgan dysfunction syndrome and mortality as a consequence of hypoperfusion and tissue hypoxia, often exacerbated by a microcirculatory injury and increased tissue metabolic demands [3, 4]. This insult sets in a chain of sequential molecular reactions resulting in further ischemic and hypoxic tissue injury. This may be further compounded by cytopathic hypoxic injury due to mitochondrial dysfunction [5, 6]. If not all, many of these complications are preventable, but at least can be minimized with good perioperative care. Liver transplantation is a growing and evolving specialty. Strategies to improve recipient’s survival are needed. One of these strategies is restrictive fluid strategies and has been found better postoperative outcomes than liberal fluid management strategies." @default.
• W4313490625 created "2023-01-06" @default.
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• W4313490625 date "2023-01-01" @default.
• W4313490625 modified "2023-10-16" @default.
• W4313490625 title "Fluid Therapy in Liver Transplant" @default.
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• W4313490625 doi "https://doi.org/10.1007/978-981-19-6045-1_19" @default.
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