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• W4313522022 abstract "Abstract Objectives. Members of the SOX family's subgroup C include SOX4, whose high expression has been linked to carcinogenesis and the development of cancer. However, it is still unclear exactly how SOX4 functions in hypopharyngeal carcinoma (HPC). Our research's objective was to discover how SOX4 affected HPC's development, migration, and prognosis. Methods. The expression levels of SOX4 and Ki-67 in tissues were examined by immunohistochemical staining (IHC) to analyze their relationship with prognosis in this study. Changes in SOX4 gene transcript levels and protein expression levels in HPC cancer tissues and adjacent normal tissues were assessed by quantitative real-time PCR (qRT-PCR) and Western blot. Cell biology and molecular assays, as well as in vivo nude mice cancer experiments, were used to evaluate the effects of SOX4 on the viability, proliferation, and migration of Fadu cells in vitro and in vivo. Results. In HPC samples, SOX4 was considerably overexpressed, and our investigation demonstrated that this overexpression was connected with differentiation ( P = 0.002), clinical stage ( P < 0.001), lymph node metastasis ( P < 0.001), tumor size ( P = 0.006) and poor survival ( P = 0.012). Moreover, knockdown of SOX4 can inhibit the proliferation, reduce their migration, and promote the epithelial to mesenchymal transition (EMT) phenotype in HPC cells. SOX4 knockdown inhibited tumor growth in vivo experiments. Conclusions. These findings collectively show that SOX4 promotes HPC migration and progression both in vitro and in vivo, and may be a prognostic marker for HPC patients." @default.
• W4313522022 created "2023-01-06" @default.
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• W4313522022 date "2023-01-03" @default.
• W4313522022 modified "2023-10-15" @default.
• W4313522022 title "Overexpression of SOX4 indicates poor prognosis and promotes progression of hypopharyngeal carcinoma" @default.
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• W4313522022 doi "https://doi.org/10.21203/rs.3.rs-2390458/v1" @default.
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